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Application of SARS2 autoantibody detection reagent in preparation of lung cancer screening kit

An autoantibody and kit technology, applied in biological tests, measuring devices, material inspection products, etc., can solve the problems of no lung cancer existing technology, no SARS2 protein, etc., and achieve low patient harm, good application prospects, and effective The effect of screening

Active Publication Date: 2019-11-15
WEST CHINA HOSPITAL SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no relevant reports on SARS2 protein autoantibodies, and there is no prior art related to lung cancer

Method used

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  • Application of SARS2 autoantibody detection reagent in preparation of lung cancer screening kit
  • Application of SARS2 autoantibody detection reagent in preparation of lung cancer screening kit
  • Application of SARS2 autoantibody detection reagent in preparation of lung cancer screening kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The relationship between SARS2 autoantibody and lung cancer in embodiment 1 plasma

[0027] 1. Clinical data

[0028] Select 30 cases of lung cancer patients, 29 cases of benign lung diseases (tuberculosis, hamartoma and other non-malignant tumors), and 30 cases of healthy controls. The basic information is as follows:

[0029] Basic Information lung cancer patients benign lung disease healthy control number of people 30 29 29 age 49.5±5.7 46.5±10 42.0±8.9 male ratio 20(66.7％) 12(41.4％) 13(46.7％)

[0030] 2. Detection principle

[0031] HuProt TM The SARS2 protein is immobilized on the human protein custom chip, and after incubation with serum, the SARS2 autoantibodies (mainly including IgG, IgM antibodies, and some other types of antibodies) in the serum will bind to it, and the unbound antibodies and other proteins will be removed by washing. Then use anti-human IgM fluorescently labeled secondary antibody (cy5-labeled, r...

Embodiment 2

[0048] Embodiment 2 The composition of detection kit of the present invention and its application method

[0049] 1. Kit composition

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Abstract

The invention relates to the field of the in-vitro diagnosis reagent, and specifically relates to an application of SARS2 autoantibody detection reagent in preparation of a lung cancer screening kit.The condition that the autoantibody level of the SARS2 protein in the lung cancer patient serum is remarkably higher than that of the health patient is firstly discovered in the invention, the reagentfor detecting the autoantibody of the SARS2 protein is used for preparing the lung cancer screening kit, thereby realizing effective screening of the lung cancer.

Description

technical field [0001] The invention relates to the field of in vitro diagnostic reagents, in particular to the use of a SARS2 autoantibody detection reagent in the preparation of a lung cancer screening kit. Background technique [0002] Lung cancer is one of the most common malignant tumors in the world. Its morbidity and mortality are increasing year by year. Currently, the incidence rate ranks first in the world, which seriously threatens human health and life. [0003] Lung cancer is a disease that is good at concealment. It often shows clinical symptoms when the disease develops to an advanced stage. 70-80% of lung cancer patients are already in the middle or late stage when they are diagnosed with lung cancer symptoms. The best cure time, five-year survival rate is low. For patients with early lung cancer, timely treatment can greatly improve the 5-year survival rate and quality of life of the patients. Therefore, early diagnosis and effective screening of lung canc...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/574
CPCG01N33/57423G01N33/57484G01N33/6884
Inventor 张立李为民
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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