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Composition for preventing and treating diseases caused by enterovirus EV71 as well as preparation method and preparation of composition

A technology of enterovirus and EV71, which is applied in the direction of antiviral agents, medical preparations containing active ingredients, and pharmaceutical formulas, can solve problems such as limited effects, cardiopulmonary failure, and death in children, and achieve remarkable effects, prevention and Significant effect of treatment

Active Publication Date: 2019-11-19
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when severe EV71 infection occurs, the inflammatory factor storm in the child's body will be activated, leading to a series of inflammatory diseases such as aseptic meningitis, resulting in cardiopulmonary failure and even death in the child
At present, the clinical treatment of severe EV71 infection is mainly achieved through the injection of broad-spectrum antiviral drugs such as immunoglobulin, glucocorticoid, and interferon, and the effects of these treatments are very limited

Method used

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  • Composition for preventing and treating diseases caused by enterovirus EV71 as well as preparation method and preparation of composition
  • Composition for preventing and treating diseases caused by enterovirus EV71 as well as preparation method and preparation of composition
  • Composition for preventing and treating diseases caused by enterovirus EV71 as well as preparation method and preparation of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Dehydrate and pulverize False Chrysanthemum and Versicolor Versicolor at a weight ratio of 2:1 at a low temperature below 20°C, add 8 times the volume of 90% ethanol to extract 3 times, each time for 3 hours, and use ultrasonic vibration to speed up the activity. The substance was dissolved, and the filtrate was combined after suction filtration, and the filtrate was concentrated and freeze-dried into a powder to obtain an alcohol extract for use. The filter residue after alcohol extraction was added to 15 times of 20°C water and ultrasonically extracted for 3 times, each time for 2 hours, after filtration, the filtrate was combined, and the filtrate was concentrated and freeze-dried into powder to obtain the water extract for use. Finally, the powder of the water extract and the powder of the alcohol extract are prepared according to the ratio of the water extract and the alcohol extract at 2:1 to obtain a composition.

Embodiment 2

[0050] Dehydrate and pulverize False Chrysanthemum and Versicolor Versicolor at a weight ratio of 1:1 at a low temperature below 20°C, add 8 times the volume of 90% ethanol to extract 3 times, each time for 3 hours, and use ultrasonic vibration to speed up the activity. The substance was dissolved, and the filtrate was combined after suction filtration, and the filtrate was concentrated and freeze-dried into a powder to obtain an alcohol extract for use. The filter residue after alcohol extraction was added to 15 times of 20°C water and ultrasonically extracted for 3 times, each time for 2 hours, after filtration, the filtrate was combined, and the filtrate was concentrated and freeze-dried into powder to obtain the water extract for use. Finally, the powder of the water extract and the powder of the alcohol extract are mixed according to the weight percentage of 65% of the water extract, 25% of the alcohol extract and 10% of ethanol to prepare a spray.

Embodiment 3

[0052] Dehydrate and pulverize False Chrysanthemum and Versicolor versicolor in a weight ratio of 3:1 at a low temperature below 20°C, add 6 times the volume of 90% ethanol to extract 3 times, each time for 3 hours, and use ultrasonic vibration to speed up the activity. The substance was dissolved, and the filtrate was combined after suction filtration, and the filtrate was concentrated and freeze-dried into a powder to obtain an alcohol extract for use. The filter residue after alcohol extraction was added to 20 times of 20°C water and ultrasonically extracted for 3 times, each time for 2 hours, after filtration, the filtrate was combined, and the filtrate was concentrated and freeze-dried into powder to obtain the water extract for use. Finally, the powder of the water extract and the powder of the alcohol extract are mixed with 55% of the water extract, 35% of the alcohol extract and 10% of ethanol to prepare a spray.

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Abstract

The invention relates to a composition for preventing and treating diseases caused by viruses, and in particular relates to a composition for preventing and treating diseases caused by enterovirus EV71 as well as a preparation method and preparation of the composition. The composition comprises the following components, in percentages by weight: 10%-80%of an alcohol extract and 10%-80% of a waterextract, wherein the alcohol extract is obtained by the steps of mixing 10%-80% by weight of amauroderma rude and 10%-80% by weight of coriolus versicolor and performing alcohol extraction, and the water extract is obtained by the step of performing water extraction on filter residues obtained after the alcohol extraction. The composition provided by the invention has a significant effect on the prevention and treatment of the diseases caused by the EV71 enterovirus, and does not show obvious side effects.

Description

technical field [0001] The invention relates to a composition for preventing and treating diseases caused by viruses, in particular to a composition, a preparation method and a preparation for preventing and treating diseases caused by EV71 enterovirus. Background technique [0002] Viruses are the main culprits of infectious diseases, which are extremely harmful and have a wide impact. In recent years, due to the wanton spread of viruses, antiviral drugs have developed rapidly and have become an important type of anti-infective drugs. However, drugs that are highly selective, act on cell virus metabolism, and have no obvious damage to the host are still under research. the key of. [0003] EV71 is a human enterovirus type 71, which belongs to the Picornavirus genus of the family Enteroviridae, and is one of the main pathogens causing hand, foot and mouth disease. EV71 mainly infects children and infants under the age of 5. In most cases, the symptoms of children are local...

Claims

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Application Information

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IPC IPC(8): A61K36/07A61P31/14
CPCA61K36/07A61K2236/33A61K2236/331A61K2236/39A61P31/14A61K2300/00
Inventor 潘鸿辉蔡超王弋雷苏炜陈少丹黄康艳吴清平谢意珍
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY