Application of citrus fruit volatile oil in preparation of food and medicine for treating hemorrhoid and food and medicine prepared by same

A technology of citrus and volatile oil, which is applied in the field of food and medicine prepared by citrus fruit volatile oil in the preparation of food and medicine for treating hemorrhoids, and can solve the problems of waste, waste of resources, unsalable bergamot, etc., and achieve therapeutic functionality Hemorrhoids, improvement of hemorrhoids, effects of avoiding waste

Inactive Publication Date: 2019-11-29
河北成弘生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Laxatives cannot be taken for a long time and can only temporarily relieve constipation symptoms. Therefore, it is of great significance to develop products that can treat functional constipation and have no side effects
[0003] At present, the citrus plants bergamot and sweet orange are widely planted in my country. The output of bergamot in Jinhua, Zhejiang has reached an annual output of 400-500 tons, which is mainly used as bergamot bonsai and fresh fruit sales. It has not expanded, which has led to unsalable and waste of bergamot. Therefore, it is particularly important to develop

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] This embodiment provides the citrus fruit volatile oil for the functional animal experiment verification of the treatment of functional constipation:

[0023] 1. Animals: 48 healthy SPF grade Wistar rats weighing 150-180 g, half male and half male.

[0024] 2. Model establishment: Use a 6mm hole punch to punch the filter paper into a disc with a diameter of 6mm, soak it in 99% glacial acetic acid solution overnight, and set it aside. After the rats were anesthetized with ether, the soaked filter paper was pasted on the mucous membrane around the anus of the rat, so that the filter paper was in close contact with the perianal skin and mucous membrane, and the filter paper was changed every 0.5 min for a total of 3 times for 1.5 minutes. min. The next day, the degree of ulceration was observed, and the rats were randomly divided into two groups according to the degree of ulceration: model group and experimental group. Measure the levels of prostaglandins, inflammatory f...

Embodiment 2

[0043] This embodiment provides a method for preparing food and medicine prepared from citrus fruit volatile oil, comprising the following steps:

[0044] Step 1: Extraction of volatile oil: after cleaning the fresh citrus fruit, cut off the pericarp, cut the pericarp into small pieces of 8mm×8mm×8mm, extract the volatile oil by steam distillation for 2 hours at a material-to-liquid ratio of 1:4, collect the volatile oil and Add anhydrous sodium sulfate for dehydration, and filter to obtain citrus fruit volatile oil. Preferably, the citrus fruit can be sweet orange, pomelo, grapefruit, tangerine or bergamot.

[0045] Step 2: After mixing the citrus fruit volatile oil and starch octenyl succinate solution in a mass ratio of 1:4, high-speed shearing at 4000r / min, homogenization at 25MPa, and preparation of citrus fruits by spray drying Volatile oil powder grease, spray drying conditions are inlet air temperature 190°C, outlet air temperature 90-100°C, sample injection speed 30m...

Embodiment 3

[0053] The present embodiment provides a method for preparing capsules containing citrus fruit volatile oil, comprising the following steps:

[0054] Step 1: Extraction of volatile oil: fresh citrus fruit, cut off the pericarp, cut the pericarp into small pieces of 8 mm × 8 mm × 8 mm, extract by steam distillation for 2 hours at a material-to-liquid ratio of 1:4, collect the volatile oil and add Dehydrated with sodium sulfate, filtered to obtain citrus fruit volatile oil.

[0055] Step 2: After mixing the citrus fruit volatile oil and starch octenyl succinate solution in a mass ratio of 1:4, high-speed shearing at 4000r / min, homogenization at 25MPa, and preparation of citrus fruits by spray drying Volatile oil powder grease, spray drying conditions are inlet air temperature 190°C, outlet air temperature 90-100°C, sample injection speed 30mL / min, centrifugal atomizer speed 20000r / min.

[0056] Step 2: Glycerin, gelatin and water are made into capsule skins by conventional phar...

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PUM

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Abstract

The invention discloses an application of citrus fruit volatile oil in preparation of food and medicine that regulate a human endocrine system and are used to treat hemorrhoid. The functional hemorrhoid can be treated by inhibiting the secretion of prostaglandin F2alpha, increasing the secretion of prostaglandin E2, reducing the expression level of inflammatory factors, improving the body's antioxidant capacity, adjusting the human endocrine system, and stimulating the hormone secretion of glands in the body to return to normal levels The product makes full use of the peel of citrus fruits, avoids waste of resources, and can effectively treat hemorrhoid without temporary eating a laxative to improve hemorrhoid.

Description

technical field [0001] The invention relates to the application of citrus fruit volatile oil in the preparation of food and medicine for treating hemorrhoids and the prepared food and medicine. Background technique [0002] Functional constipation is one of the common digestive system diseases in clinical practice. The 2016 Rome IV diagnostic criteria defined it as spontaneous defecation times less than 3 times per week, hard feces or dry fecal balls, strenuous defecation, irregular defecation, etc. Sensation of fullness, feeling of anorectal obstruction or blockage during defecation, need for manual assistance in defecation, at least 2 items, and no anatomical, neurological, or metabolic abnormalities. The incidence of functional constipation in infants and young children in my country accounts for more than 20% of pediatric gastrointestinal disease outpatient clinics, and the incidence of functional constipation in adults in my country is about 4%-6%. rate as high as 22%. ...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K47/36A61P5/00A61P9/14A23L33/105A61K131/00
CPCA23L33/105A23V2002/00A61K36/752A61K47/36A61P5/00A61P9/14A23V2200/30A61K2300/00
Inventor 吴逸群常瑞欣杨达
Owner 河北成弘生物科技有限公司
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