Method for effectively inhibiting enzymatic degradation of beauty polypeptide

A peptide enzyme and whitening technology, which is applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve problems such as narrow adaptability and peptide safety needs to be investigated, and achieves improved permeability, improved cosmetic efficacy, and improved The effect of enzymatic degradation

Pending Publication Date: 2019-12-03
浙江湃玥生物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing polypeptide anti-enzymatic degradation technology is effective for a single polypeptide, and the adaptability range is narrow, and the safety of the polypeptide after structural change needs to be investigated, which has certain limitations in the application of cosmetic efficacy

Method used

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  • Method for effectively inhibiting enzymatic degradation of beauty polypeptide
  • Method for effectively inhibiting enzymatic degradation of beauty polypeptide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) Weigh the raw materials according to the following proportions for later use

[0019] A: GHK 0.01%, glycerin 20-30%, 1,2 hexanediol 1-5%, ethylhexylglycerin 0.05-0.5%, water 70-80%, prepare cosmetic stock solution, and detect the initial peptide content after preparation;

[0020] B: Aminopeptidase 0.2-2g

[0021] C: Tranexamic acid 1-3%

[0022] (2) Add an appropriate amount of B to A, stir to dissolve, and pack separately. Add C and stir, then let it stand for 30 minutes, 90 minutes, and 120 minutes to detect the change of the peptide content by HPLC.

Embodiment 2

[0024] (1) Weigh the raw materials according to the following proportions for later use

[0025] A: GHK 0.01%, glycerin 20-30%, 1,2 hexanediol 1-5%, ethylhexylglycerin 0.05-0.5%, water 70-80%, prepare cosmetic stock solution, and detect the initial peptide content after preparation;

[0026] B: Aminopeptidase 0.2-2g

[0027] C: The molar ratio of tranexamic acid to 4MSK is 1:1, and the total amount added is 1-3%.

[0028] (2) Add an appropriate amount of B to A, stir to dissolve, and pack separately. Add C and stir, then let it stand for 30 minutes, 90 minutes, and 120 minutes to detect the change of the peptide content by HPLC.

Embodiment 3

[0030] The difference between Example 3 and Example 2 is: in C, the molar ratio of tranexamic acid to 4MSK is 2:1.

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PUM

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Abstract

The invention discloses a method for effectively inhibiting enzymatic degradation of beauty polypeptide. Tranexamic acid and 4MSK are added into a solution containing the beauty polypeptide, and the adding molar ratio of the tranexamic acid and the 4MSK is 1:1. According to the method, the enzymatic degradation of bioactive polypeptide is inhibited, the degradation of polypeptide is effectively reduced, the complete structure and the bioactivity of the polypeptide are retained, and the expected effects of the bioactive polypeptide in the field of cosmetics efficacy are achieved.

Description

technical field [0001] The invention belongs to the field of cosmetics, in particular to a method for effectively inhibiting the enzymatic degradation of biologically active polypeptides, and its medical application, especially the application of skin beauty. Background technique [0002] Cosmetic peptides are small molecular proteins with a certain sequence of amino acids connected by amide bonds. Studies have found that they play an important role in the natural aging and care of the skin, such as cell proliferation, cell migration, inflammation, angiogenesis, Pigment formation and protein synthesis and regulation. [0003] In the field of cosmetics, beauty peptides have become an important active ingredient in the field of anti-wrinkle and anti-aging, and have also played an unparalleled role in removing eye bags and dark circles, whitening the body, and promoting hair growth. Bioactive peptides have been widely used in well-known brands. Estee Lauder, Lancome, Elizabeth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/66A61K8/368A61K8/44A61K8/64A61P17/10A61P37/08A61Q19/02A61Q19/08
CPCA61K8/66A61K8/64A61K8/44A61K8/368A61Q19/02A61Q19/08A61P17/10A61P37/08
Inventor 柯勇群
Owner 浙江湃玥生物有限公司
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