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Chromosome karyotype image cutting method

A technology of chromosome karyotype and cutting method, which is applied in the field of chromosome karyotype image cutting, which can solve the problems of uneven distribution of gray scale inside the target, many impurities in the image, analysis interference, etc., and achieve clear segmentation effect, simple deployment, and reduce errors Effect

Active Publication Date: 2019-12-03
HANGZHOU DIAGENS BIOTECH CO LTD
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Problems solved by technology

[0002] At present, chromosome analysis systems generally rely on human-computer interaction to segment chromosomes. Since the quality of chromosome images is related to the dyeing quality of samples, and is seriously affected by light, there are many impurities in the image, the contrast is poor, and the chromosomes are bright and dark. Ribbon makes the gray level distribution inside the target uneven
Directly use the existing image segmentation method to segment the chromosome image. Since the chromosome image itself has a lot of noise, there will be mis-segmentation, and the resulting error will interfere with the subsequent analysis.

Method used

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  • Chromosome karyotype image cutting method
  • Chromosome karyotype image cutting method
  • Chromosome karyotype image cutting method

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specific Embodiment

[0133] The cutting method includes the following steps:

[0134] The first step is to collect the stained chromosome image;

[0135] The second step is to locate the chromosome region of interest (ROI) in the chromosome image; ensure that the image contains at least all chromosome objects (ROI) that need to be segmented;

[0136] The third step is to perform basic image processing on chromosomes;

[0137] a) Remove non-chromosomal objects with basic morphological operation image processing algorithms to obtain images that only include chromosomes as much as possible;

[0138] b) The grayscale and contrast of the image are enhanced by means of histogram normalized image processing, and the bands inside the chromosome are clearly identifiable;

[0139] The background color can be white, and the gray value of the background area is 255; those skilled in the art can choose other background colors according to actual needs;

[0140] c) Before training the deep network, the image...

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Abstract

The invention discloses a chromosome karyotype image cutting method, and belongs to the technical field of chromosome image processing. An existing image segmentation method is used for segmenting a chromosome image, due to the fact that the chromosome image has a lot of noise, the phenomenon of wrong segmentation can occur, and errors are caused to bring interference to subsequent analysis. According to the method, chromosome image segmentation is mainly carried out based on connected domain segmentation and skeleton extraction modes, after independent single chromosomes are extracted throughconnected domain analysis, skeleton extraction and skeleton analysis are carried out on remaining cross chromosomes to find possible segmentation points, and segmentation of the cross chromosomes isrealized through the segmentation points; compared with the prior art, direct segmentation of the preprocessed image is changed, the segmentation effect is clear, errors caused by segmentation are reduced to the maximum extent, the process is simple and reasonable, large-scale popularization and application can be conducted outwards, and deployment is simple.

Description

technical field [0001] The invention relates to a method for cutting a chromosome karyotype image, belonging to the technical field of chromosome image processing. Background technique [0002] At present, chromosome analysis systems generally rely on human-computer interaction to segment chromosomes. Since the quality of chromosome images is related to the dyeing quality of samples, and is seriously affected by light, there are many impurities in the image, the contrast is poor, and the chromosomes are bright and dark. Banding makes the gray level distribution inside the target uneven. Directly use the existing image segmentation method to segment the chromosome image, because the chromosome image itself has a lot of noise, there will be mis-segmentation, and the resulting error will interfere with the subsequent analysis. Contents of the invention [0003] Aiming at the defects of the prior art, the purpose of the present invention is to provide a method of segmentation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/187G06T7/194G06T7/136G06T7/66G06T7/00
CPCG06T7/187G06T7/136G06T2207/20036G06T2207/20081G06T2207/20084G06T2207/20104G06T7/11G06T7/12G06T5/30G06T5/40G06N3/08G06T2207/10056G06T2207/20032G06T2207/30024G06T5/90G06T5/70
Inventor 宋宁池浩塬秦玉磊韩云鹏马伟旗沈晓明晏青吴朝玉杨洁
Owner HANGZHOU DIAGENS BIOTECH CO LTD
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