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Composition for removing freckles, removing fine lines, dark circles and eye bags and its preparation method

A composition and derivative technology, applied in the direction of steroids, cosmetic preparations, skin care preparations, etc., can solve problems such as excessive accumulation of metabolic waste, eye pigmentation, and insufficient tissue support, and achieve the reduction of microvascular Effects of blood flow, improvement of dark circles, and reduction of vascular permeability

Active Publication Date: 2022-04-29
张传旋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, due to the slow blood flow of the eye skin blood vessels, stagnation is formed, insufficient tissue supply, excessive accumulation of metabolic waste in the blood vessels, resulting in eye pigmentation and dark circles, and because the eye skin is relatively fragile, after dark circles appear , not easy to fade, seriously affect the appearance

Method used

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  • Composition for removing freckles, removing fine lines, dark circles and eye bags and its preparation method
  • Composition for removing freckles, removing fine lines, dark circles and eye bags and its preparation method
  • Composition for removing freckles, removing fine lines, dark circles and eye bags and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0055] The method of mogrosin alcohol derivative shown in formula (I), it comprises:

[0056] Step a, weigh 5g of sodium periodate in an Erlenmeyer flask, dissolve it with 50ml of water (1ml of acetic acid to aid dissolution), then add 50ml of acetone (keep the solvent system as acetone:water = 1:1), set aside; Dissolve 5 g of mogrosin in a round bottom flask with 50 ml of acetone, then add 50 ml of water, stir at 60°C and slowly add the freshly prepared sodium periodate solution, complete the addition within 30 minutes, and react in the dark for 20 hours, evaporate the acetone under reduced pressure, Dilute with an appropriate amount of water, extract three times with dichloromethane, combine the organic phases, dry over anhydrous magnesium sulfate, evaporate the solvent under reduced pressure, separate and purify by silica gel chromatography (dichloromethane / ethyl acetate=4:1), and obtain the intermediate Body A;

[0057] Step b, weigh 3g of intermediate A in a 250ml round ...

Embodiment 2

[0061] The method of mogrosin alcohol derivative shown in formula (I), it comprises:

[0062] Step a, weigh 5g of sodium periodate in an Erlenmeyer flask, dissolve it with 50ml of water (1ml of acetic acid to aid dissolution), then add 50ml of acetone (keep the solvent system as acetone:water = 1:1), set aside; Dissolve 5 g of mogrosin in a round bottom flask with 50 ml of acetone, then add 50 ml of water, stir at 60°C and slowly add the freshly prepared sodium periodate solution, complete the addition within 30 minutes, and react in the dark for 20 hours, evaporate the acetone under reduced pressure, Dilute with an appropriate amount of water, extract three times with dichloromethane, combine the organic phases, dry over anhydrous magnesium sulfate, evaporate the solvent under reduced pressure, separate and purify by silica gel chromatography (dichloromethane / ethyl acetate=4:1), and obtain the intermediate Body A;

[0063] Step b, weigh 3g of intermediate A in a 250ml round ...

Embodiment 3

[0067] The composition for removing freckles, fine lines, dark circles and bags under the eyes comprises Mogrosanol methionine ester derivatives and rose slag alcohol extract in a weight ratio of 1:1.8. Among them, the preparation steps of rose residue alcohol extract are as follows: add rose residue to 50% ethanol solution at a material-to-liquid ratio of 1:25 (g / mL), place it in an ultrasonic extractor, extract with ultrasonic assistance for 45 minutes, and filter to remove the suspended substance. particles, take the filtrate and centrifuge at 13,000 rpm for 15 minutes, collect the supernatant, remove the extractant by rotary evaporation, and vacuum freeze-dry to obtain the rose pomace alcohol extract.

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Abstract

The invention provides a composition for removing freckles, fine lines, dark circles and bags under the eyes and a preparation method thereof, which belongs to the technical field of cosmetics, and includes mogrosanol derivatives and rose pomace alcohol extracts shown in formula (I), wherein mogrosanol The preparation method of the derivative comprises: oxidizing the o-hydroxyl structure of mogrosanol into aldehyde, then reducing the aldehyde structure to hydroxyl, then condensing with the carboxyl group of BOC-amino acid, removing BOC, and obtaining the mogrosanol derivative shown in formula (I) . The preparation method of the composition is as follows: homogeneously mixing the mogroside alcohol derivative shown in the formula (I) and the rose pomace alcohol extract to obtain the composition. The grosvenorol derivative formula of the present invention can remove calm spots on the skin surface, remove fine lines and wrinkles on the skin surface, and improve dark circles and bags under the eyes. The use of rosea alcohol in the invention can enhance the biological activity of the mogrosanol derivatives, and improve the effect of the composition on removing freckles, fine lines, dark circles and bags under the eyes.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a composition for removing freckles, fine lines, dark circles and bags under the eyes and a preparation method thereof. Background technique [0002] Skin aging is a complex process of skin physiological structure disorder and functional degeneration with aging. It is affected by internal and external factors at the same time, and generally manifests in two forms: natural aging and photoaging. Natural aging is mainly caused by endogenous factors such as genetics, and it gradually appears with the passage of time. It is mostly manifested in fine and shallow wrinkles, dry, loose and rough skin. Photoaging is caused by external environmental factors such as long-term ultraviolet radiation. The clinical characteristic changes include thick and deep wrinkles, decreased elasticity, and spot-like pigmentation. Collagen is one of the most basic components of the extracellu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/63A61K8/9789A61Q19/00A61Q19/02A61Q19/08C07J9/00
CPCA61K8/63A61K8/9789A61Q19/005A61Q19/08A61Q19/02C07J9/00
Inventor 张传旋
Owner 张传旋
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