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Botanical film-forming acne compositions

A composition and acne technology, applied in the direction of drug combination, plant/algae/fungus/moss components, plant raw materials, etc., can solve problems such as time-consuming and non-compliance of patients

Inactive Publication Date: 2019-12-20
THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, studies have shown that, like most competing anti-acne topical products currently available, the 4-step treatment is time-consuming, so patients may not adhere to the procedure

Method used

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  • Botanical film-forming acne compositions
  • Botanical film-forming acne compositions
  • Botanical film-forming acne compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Development of a stable FGZB formulation

[0062] The following formulations were prepared which included varying amounts of emulsifier, HPMCSE polymer (S), chitosan (C) and combinations of the above. These formulations were evaluated for film formation and stability.

[0063] Formulation sample EC

[0064] Element %(w / w)

[0065] Salicylic acid 2

[0066] basic ingredients

[0067]

[0068] Formulation Sample SC

[0069] Composition %(w / w)

[0070] Salicylic acid 2

[0071] basic ingredients

[0072]

[0073] Formula Sample SE-1

[0074] Composition %(w / w)

[0075] Salicylic acid 2

[0076] basic ingredients

[0077]

[0078] Formulation Sample SE- 2

[0079] Composition %(w / w)

[0080] Salicylic acid 2

[0081] basic ingredients

[0082]

[0083] Formula Sample SCE-1

[0084] Composition %(w / w)

[0085] Salicylic acid 2

[0086] basic ingredients

[0087]

[0088] Chlorhexidine gluconate 0.05

[0089] Formula Sample SCE-...

Embodiment 2

[0101] Antibacterial effect of salicylic acid combined with herbal medicine

[0102] Various plants, salicylic acid and combination were mixed in FGZ gel and the antibacterial effect was evaluated. The results are shown in the table below.

[0103] Antibacterial activity of table 1 salicylic acid and botanicals in FGZ base (inhibition zone test)

[0104]

[0105]

[0106] Table 1

[0107] "Plant Blend" includes: Pomegranate Extract (0.5%), Rosemary Oil (0.1%), Orange Oil (0.2%), Vetiver Oil (0.02%), Pterostilbene Extract (0.1%), Plant Based Benzyl Alcohol (1%), Plant Based 1,3 Propanediol (2%).

[0108] in conclusion: A botanical blend synergistically enhances the efficacy of salicylic acid.

[0109] Table 2 antibacterial activity (killing the rapidity of test bacteria Staphylococcus aureus)

[0110] Rapid kill (15 seconds) test tube method described in ASTM-E2783-1198751-1 (suspension test).

[0111] The in vitro rapid kill test was performed according to ASTM E...

Embodiment 3

[0118] Various SCE-zinc salt film (FGZ) formulations containing salicylic acid and botanicals (FGZB), eg cleansers, lotions and spot creams were prepared as follows and found to be stable and effective.

[0119] HGZB cleaner C-7

[0120] Phase A (50-60)

[0121]

[0122] Phase B Plant Blend

[0123]

[0124]

[0125] HGZB cleaner C-8

[0126] Phase A (50-60)

[0127]

[0128] Phase B Plant Blend

[0129]

[0130] HGZB cleaner F-3 pH4.5

[0131]

[0132]

[0133] HGZB cleaner F-4 pH 4.5

[0134]

[0135] HGZB cleaner F-5 pH 4.5

[0136]

[0137] HGZB cleaner F-7 pH4.0

[0138]

[0139]

[0140] HGZB cleaner F-8 pH 4.0

[0141]

[0142]

[0143] HGZB cleaner F-9 pH 4.0

[0144]

[0145]

[0146] HGZB cleaner F-13 pH4.0

[0147]

[0148] HGZB cleaner F-14 pH 4.0

[0149]

[0150] HGZB cleaner F-15 pH 4.0

[0151]

[0152]

[0153] HGZB cleaner F-16 pH 4.0

[0154]

[0155]

[0156...

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Abstract

The present technology relates to botanical film-forming compositions useful for the treatment of acne related skin disorders, as well as methods of treating such disorders. The compositions herein are advantageous in that they treat acne related skin disorders quickly and with minimal irritation and side effects.

Description

technical field [0001] The present technology relates to compositions useful in the treatment of acne-related skin disorders. Background technique [0002] Acne, also known as acne vulgaris, is a chronic inflammatory disease of the skin that occurs in 80% of adolescents and young adults. It is a skin disorder characterized by primary lesions on the face, chest, and back that develop when skin pores become clogged with oil, dead skin cells, and bacteria. Acne often occurs when the sebaceous glands overproduce sebum. Clogged pores can also collect dirt, debris, and bacteria. When a blockage or plug (comedone) breaks open, the material inside spreads to the surrounding skin. The resulting sebum-rich dermatosis is prone to anaerobic growth of P. acnes, the major acne-causing microorganism. In addition, S. epidermidis and S. aureus can be present in acne lesions. Proliferation of these microorganisms (mainly P. acnes) leads to inflammatory lesions and severe acne. [0003] ...

Claims

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Application Information

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IPC IPC(8): A61K33/30A61K31/60A61K31/315A61K31/19A61K31/194A61K36/896A61K36/886A61K36/899A61K47/38A61K47/20A61K47/10A61K47/12A61P17/10A61P17/04A61P17/00A61P17/08A61P31/04A61P31/02A61K31/722A61K31/352A61K31/05A61K31/045
CPCA61K36/899A61K36/896A61K36/886A61K36/82A61K36/81A61K36/752A61K36/74A61K36/61A61K36/53A61K36/484A61K36/48A61K36/324A61K36/28A61K36/185A61K33/30A61K31/722A61K31/60A61K31/352A61K31/315A61K31/194A61K31/19A61K31/05A61K31/045A61K47/38A61K47/20A61K47/10A61K47/12A61P17/10A61P17/04A61P17/00A61P17/08A61P31/04A61P31/02A61K2300/00A61K31/192A61K31/327A61K9/0014A61K9/06A61K9/107
Inventor S·M·莫代克C·C·德西尔瓦
Owner THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK