A kind of bifunctional starch-based composite nanoparticle and its preparation method and application

A composite nanoparticle and functional technology, applied in the field of starch deep processing, can solve the problems of poor stability of double emulsion and limited industrial application.

Active Publication Date: 2021-09-14
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

W 1 / O / W 2 A major disadvantage of double emulsions is their poor stability, which limits their industrial applications

Method used

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  • A kind of bifunctional starch-based composite nanoparticle and its preparation method and application
  • A kind of bifunctional starch-based composite nanoparticle and its preparation method and application
  • A kind of bifunctional starch-based composite nanoparticle and its preparation method and application

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preparation example Construction

[0050] One aspect of the embodiments of the present invention provides a method for preparing bifunctional starch-based composite nanoparticles, which includes:

[0051] Perform hydrolysis treatment on starch to form starch hydrolyzate and obtain linear dextrin;

[0052] The linear dextrin is classified by an alcohol-alcohol gradient precipitation method to obtain a linear dextrin with uniform molecular weight distribution;

[0053] Oxidizing the linear dextrin by using a TEMPO / NaClO / NaBr oxidation system to obtain oxidized dextrin;

[0054] making the first mixed system comprising oxidized dextrin and curcumin undergo a complex reaction to form an oxidized dextrin-curcumin complex; and,

[0055] Make the oxidized dextrin-curcumin complex and chitosan hydrochloride form oxidized dextrin-curcumin / chitosan hydrochloride composite nanoparticles through electrostatic complexation to obtain the bifunctional starch-based composite nanoparticles.

[0056] In some embodiments, the ...

Embodiment 1

[0138] 1) Preparation of linear dextrin (LD)

[0139] 20g of ordinary cornstarch is configured into starch milk with a mass fraction of 5wt%, placed in a boiling water bath and stirred for 1h to completely gelatinize the starch, and further place the gelatinized starch in an acetate solution (0.02mol / L, with a pH of 6) Add 80U α-amylase, carry out hydrolysis treatment at 60°C for 1.5h, heat up to 100°C for enzyme inactivation treatment, add 1000U pullulanase for debranching treatment at 55°C for 3h, after the reaction, put the reaction solution in Inactivate the enzyme in a boiling water bath for 10 minutes. The reactant was centrifuged at 4500 g for 20 min, the precipitate was discarded, the supernatant was subjected to rotary evaporation, and vacuum freeze-dried to obtain linear dextrin.

[0140] 2) Grading of linear dextrins

[0141] LDs were fractionated by alcohol-alcohol precipitation gradient precipitation. Briefly, absolute ethanol was slowly added to the LD dispers...

Embodiment 2

[0154] 1) Preparation of linear dextrin (LD)

[0155] 20g waxy corn starch is configured into starch milk with a mass fraction of 5wt%, placed in a boiling water bath and stirred for 1h to completely gelatinize the starch, and further place the gelatinized starch in an acetate solution (0.02mol / L, pH = 6) Add 40U α-amylase, perform hydrolysis treatment at 50°C for 2 hours, heat up to 110°C for enzyme inactivation treatment, add 600U pullulanase for debranching treatment for 3.5 hours after cooling to 60°C, and place the reaction solution in the Inactivate the enzyme in a boiling water bath for 15 minutes. The reactant was centrifuged at 4500 g for 20 min, the precipitate was discarded, the supernatant was subjected to rotary evaporation, and vacuum freeze-dried to obtain linear dextrin.

[0156] 2) Grading of linear dextrins

[0157] LDs were fractionated by alcohol-alcohol precipitation gradient precipitation. In brief, absolute ethanol was slowly added to the LD dispersio...

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Abstract

The invention discloses a bifunctional starch-based composite nanoparticle, a preparation method and application thereof. The preparation method comprises: hydrolyzing starch to form linear dextrin, and adopting an alcohol-alcohol gradient precipitation method to classify it to obtain linear dextrin with uniform molecular weight distribution; using an oxidation system to oxidize linear dextrin to obtain oxidized dextrin. Dextrin; make oxidized dextrin and curcumin undergo complex reaction to form oxidized dextrin-curcumin complex; make it form oxidized dextrin-curcumin / chitosan hydrochloride complex with chitosan hydrochloride nanoparticles. The aqueous phase solution of bifunctional starch-based composite nanoparticles containing curdlan is uniformly mixed with the primary emulsion, and the obtained double emulsion is subjected to calcium ion induction treatment to obtain a double emulsion gel, which has good oxidation resistance and long-term Storage stability, can be used in the protection of nutritional ingredients, drug delivery and preparation of cosmetics and other fields.

Description

technical field [0001] The invention relates to a bifunctional starch-based composite nanoparticle and a preparation method thereof, and the bifunctional starch-based composite nanoparticle is used in the preparation of stable W 1 / O / W 2 The application in double emulsion gel belongs to the technical field of starch deep processing. Background technique [0002] The modern food industry pays more and more attention to functional foods that improve human nutrition and health, and a large number of bioactive substances are widely used in various food systems. However, most of these substances have poor stability and their bioactive components are easily destroyed, which limits their application in the food industry. Fat-soluble nutrients, including fat-soluble vitamins (V A , V D and V E ), polyunsaturated fatty acids (EPA, DHA and CLA), carotenoids and hydrophobic plant polyphenols (tea polyphenols, curcumin and isoflavones, etc.), due to poor solubility, easy to oxidati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L3/10C08L5/08C08L5/04C08L5/00C08K5/132C08J3/03C12P19/04C12P19/14C12P19/16
CPCC08J3/03C08J2303/10C08J2405/00C08J2405/04C08J2405/08C08L3/10C12P19/04C12P19/14C12P19/16C08L5/08C08K5/132
Inventor 章宝徐宝才李小敏潘怡孟然李小龙李沛军
Owner HEFEI UNIV OF TECH
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