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A kind of Chuan Mingshen alcohol extract and application and alcohol extraction method

A technology of alcohol extraction and Chuanming ginseng, which is applied in the field of Chuanming ginseng alcohol extraction and application and alcohol extraction, can solve the problems of adverse reactions of cardiovascular diseases, etc., and achieve the increase of HDL-C, the improvement of extraction rate, and strong effect of ability

Active Publication Date: 2022-02-01
XIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above-mentioned prior art, the present invention provides an alcoholic extract of Chuanmingshen and an alcoholic extraction method of Chuanmingshen to solve the problem that existing drugs easily cause adverse reactions in the treatment of cardiovascular diseases

Method used

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  • A kind of Chuan Mingshen alcohol extract and application and alcohol extraction method
  • A kind of Chuan Mingshen alcohol extract and application and alcohol extraction method
  • A kind of Chuan Mingshen alcohol extract and application and alcohol extraction method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A method for alcohol extraction of Chuanming ginseng, comprising the steps of:

[0039] S1: Take Chuanming ginseng with a moisture content of less than 8%, and crush it into a powder with a particle size of about 50 mesh;

[0040] S2: Mix Chuanming ginseng powder with 95% ethanol at a solid-liquid ratio of 2g:5mL, adjust the pH to 4.5, and let stand for 1h;

[0041] S3: Place the mixture treated by S2 in an ultrasonic extraction device for ultrasonic extraction. During the extraction process, the ultrasonic frequency is 16KHz, the ultrasonic power is 200W, and the extraction time is 4.5h; then the mixture is filtered and vacuum concentrated to obtain an extract;

[0042] S4: Use silica gel column chromatography to purify the extract to obtain the ethanol extract of Chuan Mingshen; the eluent used in silica gel column chromatography is cyclohexane-ethyl acetate-methanol mixture, and cyclohexane, ethyl acetate The volume ratio of ester and methanol is 5:3:2.

[0043] Th...

Embodiment 2

[0046] A method for alcohol extraction of Chuanming ginseng, comprising the steps of:

[0047] S1: Take Chuanming ginseng with a moisture content of less than 8%, and crush it into a powder with a particle size of about 60 mesh;

[0048] S2: Mix Chuanming ginseng powder with 95% ethanol at a solid-liquid ratio of 3g:8mL, adjust the pH to 4.0, and let stand for 1h;

[0049] S3: Place the mixture treated by S2 in an ultrasonic extraction device for ultrasonic extraction. During the extraction process, the ultrasonic frequency is 15KHz, the ultrasonic power is 190W, and the extraction time is 5h; then the mixture is filtered and vacuum concentrated to obtain an extract;

[0050] S4: Use silica gel column chromatography to purify the extract to obtain the ethanol extract of Chuan Mingshen; the eluent used in silica gel column chromatography is cyclohexane-ethyl acetate-methanol mixture, and cyclohexane, ethyl acetate The volume ratio of ester and methanol is 5:4:1.

[0051] The ...

Embodiment 3

[0054] A method for alcohol extraction of Chuanming ginseng, comprising the steps of:

[0055] S1: Take Chuanming ginseng with a moisture content of less than 8%, and crush it into a powder with a particle size of about 40 mesh;

[0056] S2: Mix Chuanming ginseng powder with 95% ethanol at a solid-liquid ratio of 1g:2mL, adjust the pH to 5.0, and let stand for 0.5h;

[0057] S3: Place the mixture treated by S2 in an ultrasonic extraction device for ultrasonic extraction. During the extraction process, the ultrasonic frequency is 18KHz, the ultrasonic power is 180W, and the extraction time is 4h; then the mixture is filtered and vacuum concentrated to obtain an extract;

[0058]S4: Use silica gel column chromatography to purify the extract to obtain the ethanol extract of Chuan Mingshen; the eluent used in silica gel column chromatography is cyclohexane-ethyl acetate-methanol mixture, and cyclohexane, ethyl acetate The volume ratio of ester and methanol is 5:3:3.

[0059] The...

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Abstract

The invention discloses an alcoholic extract of Chuanming ginseng, its application and an alcoholic extraction method. During the alcohol extraction, the Chuanming ginseng is first ground into powder, then the Chuanming ginseng powder is mixed with an ethanol solution, and the pH of the mixture is adjusted to weak Acidic, after standing for a period of time, the mixture is placed in an ultrasonic extraction device for ultrasonic extraction, and finally the ultrasonic extract is purified by silica gel column chromatography to obtain the alcoholic extract of Dechuan Mingshen. The obtained ethanol extract has a strong ability to reduce serum TC and LDL-C, and has certain functions of raising HDL-C and lowering TG. By inhibiting the key enzymes of lipid metabolism such as ACAT and DGAT, CEE can regulate blood lipids while protecting against tissue lesions such as atherosclerosis and hepatic steatosis, and can delay the related pathological process.

Description

technical field [0001] The invention belongs to the technical field of alcohol extraction, and in particular relates to an alcohol extraction of Chuanming ginseng, its application and an alcohol extraction method. Background technique [0002] Chuanminshen (Chuanminshen violaceum Shen et Shan) belongs to Umbelliferae, Umbellifera, and is a plant of the genus Chuanminshen. It is a special product in my country. It is mainly distributed in Sichuan and Hubei. It is a famous medicinal material. It is mainly produced in Bazhong, Cangxi, and Jintang in Sichuan. and other areas. The roots of Chuanming ginseng are used as medicine, and at the same time, Chuanming ginseng is also eaten as a tonic. It is suitable for tonifying deficiency and strengthening the body after illness. It is a plant with the same medicine and food. The active ingredients contained in Chuanming ginseng are mainly polysaccharides and coumarin. The known pharmacological activities include anti-oxidation, elimin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/23A61P3/06A61P9/10C07D493/04
CPCA61K36/23A61P3/06A61P9/10C07D493/04A61K2236/333A61K2236/39A61K2236/53A61K2236/51A61K2236/55
Inventor 赖朋张驹张梦徐侨曹旭张良李锐
Owner XIHUA UNIV
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