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Eye cream preparation taking flexible nanoliposome as carrier and preparing method of eye cream preparation

A nano-liposome and eye cream technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problem of liposome vesicles entering deep skin cells, complex and diverse causes of dark circles, and loss of network support etc., to improve dark circles and puffiness, spread and spread evenly, and achieve transdermal delivery

Inactive Publication Date: 2020-01-10
张瀚文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

1. The appearance of wrinkles around the eyes is due to insufficient replenishment of collagen and elastic fibers in the dermis, resulting in thinning, loss of mesh support, skin loss of elasticity, and it is difficult to recover after being squeezed, resulting in wrinkles
2. The skin around the eyes is only 0.07mm, and there are basically no sebaceous glands distributed, so it is easy to lack sufficient sebum to maintain moisture, resulting in the appearance of dry lines
4. The causes of dark circles are more complex and diverse
Ordinary liposomes generally adopt a rigid design in order to maintain stability during storage and circulation in the blood, but this design is not conducive to liposome vesicles entering the deep skin cells through the stratum corneum gap

Method used

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  • Eye cream preparation taking flexible nanoliposome as carrier and preparing method of eye cream preparation
  • Eye cream preparation taking flexible nanoliposome as carrier and preparing method of eye cream preparation
  • Eye cream preparation taking flexible nanoliposome as carrier and preparing method of eye cream preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Weigh and mix 486g of deionized water, 20g of Tween 20, 10g of caffeine, 15g of resveratrol, 2g of pentapeptide, 55g of glycerin, and 10g of licorice extract, heat to 40°C, and stir magnetically at 300r / min to the water phase The ingredients were completely dissolved. Continue to insulate and stir for 30 minutes to become the water phase. Weigh 100g of distearoylphosphatidylcholine, 150g of absolute ethanol, 11g of Span 20, 5g of retinol, 50g of butanediol, and 10g of Matricaria flower extract and mix them, heat to 40°C, and stir with 600r / min magnetic force until all ingredients are completely dissolved. Continue to insulate and stir for 10 minutes to become the organic phase. Slowly inject the mixed organic phase into the water phase while maintaining temperature control at 40°C. Stir and mix the two phases with a 600r / min stirring paddle to form a liposome system. After the organic phase is completely injected, continue to stir under temperature control for 10 minu...

Embodiment 2

[0039] Deionized water 528g, Tween 80 50g, poloxamer 12g, red wine polyphenol 4g, dipotassium glycyrrhizinate 12g, oligopeptide-12g, hexapeptide 1g, tremella polysaccharide 8g, sodium hyaluronate 5g, polygu Weigh and mix 20 g of sodium bicarbonate and 16 g of arnica extract, heat to 60° C., and stir with a 250 r / min stirring paddle until all components of the water phase are completely dissolved. Continue to insulate and stir for 15 minutes to become the water phase. Weigh 125g soybean lecithin, 180g denatured ethanol, 15g green tea extract, 1g clary sage essential oil, 5g milk thistle extract, weigh and mix, heat to 60°C, and stir magnetically at 150r / min until all ingredients are completely dissolved. Continue to insulate and stir for 30 minutes to become the organic phase. Slowly inject the mixed organic phase into the water phase, while maintaining temperature control at 60°C, and quickly mix the two phases with high-speed shearing to form a liposome system. After the org...

Embodiment 3

[0041] Deionized water 520g, Tween 80 48g, ascorbic acid 20g, hexapeptide 5g, glutathione 2g, sodium hyaluronate 5g, allantoin 20g, ectoine 18g, yeast extract 50g, guarana 35g of extract and 10g of roselle extract were weighed and mixed, heated to 50°C, and magnetically stirred at 300r / min until the components of the water phase were completely dissolved. Continue to keep warm and stir for 10 minutes to become the water phase. Weigh and mix egg yolk lecithin 100g, absolute ethanol 85g, Span 80 5g, lemon fruit essential oil 2g, milk thistle extract 3g, rosemary extract 6g, menthol 6g, heat to 50°C, 100r / min Stir with paddle until ingredients are completely dissolved. Continue to insulate and stir for 20 minutes to become the organic phase. Slowly inject the mixed organic phase into the water phase, while maintaining temperature control at 50°C, and quickly mix the two phases with high-speed shearing to form a liposome system. After the organic phase is completely injected, co...

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Abstract

The invention provides an eye cream preparation taking flexible nanoliposome as a carrier and a preparing method of the eye cream preparation. The eye cream preparation is prepared from the followingcomponents in percentage by mass: 20-80% of deionized water, 0.5-20% of phospholipid, 3-40% of ethyl alcohol, 0-5% of plant essential oil, 0.1-10% of an emulsifying agent, 0.5-20% of an antioxidant, 0.05-5% of polypeptide, 2-20% of a humectant, 1-20% of a plant extract, 0.2-2% of a preservative, 0.1-15% of a thickening agent, and 0-1% of essence, wherein the sum of the mass fraction of the components is 100%. A unique composition formula is formed for various periorbital problems, the stability of the active components is also ensured through the liposome, the flexible nanoliposome different from previous rigid liposome is invented, and the situation that the liposome carries the effective components to realize percutaneous permeability is better achieved.

Description

technical field [0001] The invention belongs to the technical field of eye cream products, and in particular relates to an eye cream preparation with flexible nano liposome as a carrier and a preparation method thereof. Background technique [0002] The skin around the eyes is thin and vulnerable to the external environment, and it is also one of the most prone to aging. Because of this, consumers tend to pay more attention to eye care than other facial care and have higher requirements for eye care products. People's functional demands on eye care products are multifaceted and comprehensive. Several important functional directions include 1. Reduce wrinkles around the eyes 2. Reduce dry lines around the eyes 3. Improve puffiness 4. Improve dark circles. For these functional requirements, the corresponding mechanism of action is multifaceted. 1. The appearance of wrinkles around the eyes is due to insufficient replenishment of collagen and elastic fibers in the dermis, re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/9771A61K8/92A61K8/67A61K8/64A61K8/49A61K8/34A61K8/14A61Q19/00A61Q19/08
CPCA61K8/9789A61K8/9771A61K8/922A61K8/64A61K8/671A61K8/345A61K8/4953A61K8/14A61Q19/00A61Q19/08A61Q19/005
Inventor 张瀚文
Owner 张瀚文
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