Zeaxanthine dipalmitate liposome eye drops and preparation method thereof

A technology of palmitate and zeaxanthin, which is applied in the direction of liposome delivery, pharmaceutical formulations, active ingredients of esters, etc., can solve the problems of no safety testing and efficacy verification, differences, and unclear use effects, etc., to improve biological Utilization, various action effects, macular degeneration prevention effect

Active Publication Date: 2021-09-17
宁夏全通枸杞供应链管理股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Chinese invention patent (patent application number 201810471700.7, publication number CN110496170A, application date: 2018-05-17), the title of the invention is "an eye protection solution for preventing myopia", which discloses an eye drop, which is mainly used For the prevention of myopia, the effect of the present invention is obviously different; and the patent has not carried out relevant safety testing and efficacy verification, making the final use effect unclear

Method used

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  • Zeaxanthine dipalmitate liposome eye drops and preparation method thereof
  • Zeaxanthine dipalmitate liposome eye drops and preparation method thereof
  • Zeaxanthine dipalmitate liposome eye drops and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0048] Zeaxanthin dipalmitate was dissolved with a small amount of absolute ethanol (see Annex formula figure 1 ) 20mg, Compound lecithin and Tween 800.5mg 400mg, rotary evaporated under reduced pressure to the film formation; the amount of 10mL water for injection preheated at 50 ℃; post under the same conditions, hydration water for injection, the solution was completely dissolved to an ultrasonic homogenous, clear, filter sterilized 0.22 m, to obtain 2mg / mL zeaxanthin dipalmitate liposomes (with figure 2 ), Particle size distribution mitsuke image 3 . Then diluted with MEM medium containing serum and double antibody zeaxanthin dipalmitate into liposomes 1.6mg / mL, 1.2mg / mL, 0.8mg / mL, 0.4mg / mL.

[0049] A compound described above in the embodiment lecithin embodiment comprises egg yolk lecithin, anhydrous butter, cholesterol, which is a mass ratio of 3: 2: 1.

Embodiment 2

[0051] Percentage by mass weighed raw glycerol and 0.05% Phenoxyethanol 0.20% mixture is placed on a magnetic stirrer set speed of 800rpm and 35 ℃, dissolved stirred until homogeneous; mass percentage of the water for injection feed weighed 93.95%, transparent sodium hyaluronate 0.10%, 0.10% panthenol, vitamin B120.05%, vitamin B60.05% sodium chloride and 0.5%, the raw material added in small amounts several times, dissolved stirred until homogeneous; mass percentage of the raw materials weighed zeaxanthin dipalmitate esters 5.00% was added to the liposome raw material, stirred until homogeneous, to give a clear pale yellow transparent liquid, liquid with boric acid to adjust the pH to 6.5 to 5.1, filter sterilized, bottling, that is, the zeaxanthin dipalmitate ester liposome eye drops.

Embodiment 3

[0053] Percentage by mass weighed raw glycerol and 0.05% Phenoxyethanol 0.20% mixture is placed on a magnetic stirrer set speed of 800rpm and 35 ℃, dissolved stirred until homogeneous; mass percentage of the water for injection feed weighed 88.95%, transparent sodium hyaluronate 0.10%, 0.10% panthenol, vitamin B120.05%, vitamin B60.05% sodium chloride and 0.5%, the raw material added in small amounts several times, dissolved stirred until homogeneous; mass percentage of the raw materials weighed zeaxanthin dipalmitate 10.00% acetate was added to the liposome raw material, stirred until homogeneous, to give a clear pale yellow transparent liquid, liquid with boric acid to adjust the pH to 6.5 to 5.1, filter sterilized, bottling, that is, the zeaxanthin dipalmitate ester liposome eye drops.

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Abstract

The invention relates to eye drops prepared by using a liposome technology, in particular to a formula of zeaxanthine dipalmitate liposome eye drops and a preparation method thereof. The zeaxanthine dipalmitate liposome eye drops are prepared from the following raw materials in percentage by mass: 78.00 to 94.00 percent of water for injection, 5.00 to 25.00 percent of zeaxanthine dipalmitate liposome, 0.05 to 0.30 percent of sodium hyaluronate, 0.05 to 0.15 percent of panthenol, 0.05 to 0.10 percent of boric acid, 0.01 to 0.05 percent of vitamin B12, 0.01 to 0.05 percent of vitamin B6, 0.01 to 0.05 percent of glycerol, 0.50 to 0.70 percent of sodium chloride and 0.10 to 0.30 percent of phenoxyethanol. The eye drops are relatively simple in formula, good in stability and non-irritant to human eyes, zeaxanthin dipalmitate is entrapped by lipidosome, the problems of poor water solubility and low bioavailability are fundamentally solved, the eye drops can enter corneal cells more easily, leakage is reduced, meanwhile, the stability is improved. The efficient delivery of the zeaxanthine dipalmitate is fully realized, and the effect of improving eyesight is achieved.

Description

Technical field [0001] The present invention relates to the field of pharmaceutical preparations, and more particularly to a drops of a carrier with a corn dual palmitate liposome and a preparation method thereof. Background technique [0002] Eyes as the primary feeling of human beings, the human eye should handle a lot of information every day to read a lot of text. Once it is unhealthy, unsanitary, it is especially prone to various visual fatigue, the eyes are dry, the eyelids, redness and swelling, the blurred blurring, etc. healthy. The reason is that fatigue symptoms are highlighted by eye itself and environmental factors. In addition, the harsh surrounding environment will also exacerbate the occurrence and development of fatigue symptoms. [0003] It is now solving the relatively single drop of this symptoms on the market, and cannot be specified, so the use of liposome technology development is safe and effective, can alleviate the perspective of various reasons, prevent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/23A61K31/728A61K47/24A61K47/26A61K47/28A61P27/02A61P39/06A61K31/164A61K31/4415A61K31/714
CPCA61K31/23A61K9/0048A61K9/127A61K47/24A61K47/28A61K47/26A61P27/02A61P39/06A61K31/728A61K31/164A61K31/4415A61K31/714A61K2300/00
Inventor 李明媛李萌王珊珊贾琳包莉媛李媛王志遥谢焱博苏雯郁彭
Owner 宁夏全通枸杞供应链管理股份有限公司
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