Zeaxanthine dipalmitate liposome eye drops and preparation method thereof

Abstract

The invention relates to eye drops prepared by using a liposome technology, in particular to a formula of zeaxanthine dipalmitate liposome eye drops and a preparation method thereof. The zeaxanthine dipalmitate liposome eye drops are prepared from the following raw materials in percentage by mass: 78.00 to 94.00 percent of water for injection, 5.00 to 25.00 percent of zeaxanthine dipalmitate liposome, 0.05 to 0.30 percent of sodium hyaluronate, 0.05 to 0.15 percent of panthenol, 0.05 to 0.10 percent of boric acid, 0.01 to 0.05 percent of vitamin B12, 0.01 to 0.05 percent of vitamin B6, 0.01 to 0.05 percent of glycerol, 0.50 to 0.70 percent of sodium chloride and 0.10 to 0.30 percent of phenoxyethanol. The eye drops are relatively simple in formula, good in stability and non-irritant to human eyes, zeaxanthin dipalmitate is entrapped by lipidosome, the problems of poor water solubility and low bioavailability are fundamentally solved, the eye drops can enter corneal cells more easily, leakage is reduced, meanwhile, the stability is improved. The efficient delivery of the zeaxanthine dipalmitate is fully realized, and the effect of improving eyesight is achieved.

Description

Technical field [0001] The present invention relates to the field of pharmaceutical preparations, and more particularly to a drops of a carrier with a corn dual palmitate liposome and a preparation method thereof. Background technique [0002] Eyes as the primary feeling of human beings, the human eye should handle a lot of information every day to read a lot of text. Once it is unhealthy, unsanitary, it is especially prone to various visual fatigue, the eyes are dry, the eyelids, redness and swelling, the blurred blurring, etc. healthy. The reason is that fatigue symptoms are highlighted by eye itself and environmental factors. In addition, the harsh surrounding environment will also exacerbate the occurrence and development of fatigue symptoms. [0003] It is now solving the relatively single drop of this symptoms on the market, and cannot be specified, so the use of liposome technology development is safe and effective, can alleviate the perspective of various reasons, prevent...

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Problems solved by technology

[0008] Chinese invention patent (patent application number 201810471700.7, publication number CN110496170A, application date: 2018-05-17), the title of the invention is "an eye protection solution for preventing myopia", which discloses an eye drop, which is mainly used For the prevention of myopia, the effect of the present invention is obviously different; and the patent has not carried out relevant safety testing and efficacy verification, making the final use effect unclear

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