31 results about "Ganciclovirum" patented technology

The invention provides a ganciclovir preparation method, which comprises: 1, carrying out a condensation reaction process by adopting glycerol acetal ester and diacetyl guanine as raw materials and dioxane as a solvent under the effect of trifluoroacetic acid, and carrying out post-treatment to obtain triacetyl ganciclovir, 2, hydrolyzing the triacetyl ganciclovir obtained in the step 1 to obtaina ganciclovir crude product, and 3, refining the ganciclovir crude product obtained in the step 2 to obtain a ganciclovir finished product. According to the method, based on diacetyl guanine, the total yield reaches 35%-40%, the quality of the prepared bulk drug product is greatly improved, the contents of the impurity C and the impurity F (guanine) are controlled to 0.05% or below, the total impurity content is 0.06%-0.10%, and the product purity is greater than 99.9%.

The invention discloses a preparation method of ganciclovir sodium freeze-dried powder for injection, which comprises the following steps in sequence: adding mannitol into water for injection, adding activated carbon, stirring and standing still, and then decarbonizing by coarse filtration; The decarbonized mannitol solution is passed through a sterile mixed cellulose film to obtain a purified mannitol solution; adding ganciclovir sodium to the purified mannitol solution, and then passed through a sterile mixed cellulose film to obtain Ganciclovir sodium solution; Described Ganciclovir sodium solution is carried out temperature control, and with CO 2 Adjusting the pH value; putting the ganciclovir sodium solution in a bottle, half-tamping and then freeze-drying; after the freeze-drying is finished, pressing and re-pressing to obtain the ganciclovir sodium freeze-dried powder for injection. The mannitol of the present invention is more suitable for the storage of the ganciclovir sodium freeze-dried powder as the protective agent of the ganciclovir sodium freeze-dried powder, and can better ensure the purity of the ganciclovir sodium freeze-dried powder.

The invention provides a Gancilorvir dispersable tablet and its preparation, wherein the dispersion tablet comprises 62.5 wt% of Ganciclovir, 10-25% of crystalline cellulose, or calcium hydrogen phosphate and / or starch, 1-10% of sodium carboxymethylstarch, or low substituted methylcellulose propylene glycol ether and / or cross bonding polyvinylpyrrolidone or crosslinked sodium carboxymethylcellulose, 0.1-1.4% of polyvinylpyrrolidone, or methyl hydroxypropylcellulose, 5-15% of lactose, 0.5-1.4% of magnesium stearate. The preparing process comprises sieving, mixing, granulating, drying, and tabletting.

The present invention relates to an ophthalmic composition, which comprises ganciclovir and olopatadine; wherein, the mass ratio of ganciclovir to olopatadine is (2‑6):1. The present invention also relates to a preparation method of an ophthalmic composition, comprising: step S1, mixing ganciclovir, olopatadine, an osmotic pressure regulator, a pH regulator and water for injection at a temperature of 90-100°C , to obtain a mixed solution; step S2, at a temperature of 70-80° C., adding a solubilizer, a preservative and water for injection to the mixed solution to obtain the ophthalmic composition. In addition, the present invention also relates to the application of the ophthalmic composition in the preparation of medicines for treating keratitis. The eye drops containing the ophthalmic composition provided by the invention not only have good anti-inflammatory and anti-viral effects, but also can avoid adverse reaction symptoms such as eyelid edema, conjunctival hyperemia, pain and burning sensation in patients with long-term use.