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Method for recycling ganciclovir condensation compound synthesis mother liquor

A technology for ganciclovir condensate and synthesizing mother liquor is applied in the field of recycling of ganciclovir condensate synthesizing mother liquor, which can solve the problems of increasing raw material cost, environmental impact, waste of resources and the like, achieve good social benefits and reduce raw materials cost, the effect of realizing resource recycling and utilization

Pending Publication Date: 2022-05-13
HUBEI HONGYUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The amount of mother liquor produced after centrifugation of ganciclovir condensate is large, and it is directly treated as production waste liquid, which not only wastes resources, increases the cost of raw materials, but also has a certain impact on the environment
In view of the lack of post-treatment in the existing ganciclovir condensate production process, there is an urgent need for a method for recycling toluene and ganciclovir condensate isomers in the reaction system

Method used

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  • Method for recycling ganciclovir condensation compound synthesis mother liquor
  • Method for recycling ganciclovir condensation compound synthesis mother liquor
  • Method for recycling ganciclovir condensation compound synthesis mother liquor

Examples

Experimental program
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Effect test

Embodiment 1

[0038] After the condensation reaction is finished, the reaction solution is preliminarily treated, cooled to room temperature, and isomers of the ganciclovir condensate are separated out, and the isomers of the ganciclovir condensate are centrifugally dried. Return the mother liquor of ganciclovir condensate isomer after centrifugation to the inside of the kettle. After concentrating under reduced pressure at a temperature of ≦70°C, evaporate the solvent to dryness, then add 100kg of methanol and 1200kg of toluene into the kettle, and raise the temperature to reflux state and drop to 5°C The ganciclovir condensate is separated out, and the ganciclovir condensate is obtained by centrifugation. The centrifuged ganciclovir condensate mother liquor is returned to the kettle at a temperature ≦110°C, concentrated at normal pressure and then concentrated under reduced pressure, and methanol toluene is distilled off. Add 100kg of water to the bottom liquid in the still, so that the g...

Embodiment 2

[0044]After the condensation reaction is finished, the reaction solution is preliminarily treated, cooled to room temperature, and isomers of the ganciclovir condensate are separated out, and the isomers of the ganciclovir condensate are centrifugally dried. Return the mother liquor of ganciclovir condensate isomer after centrifugation to the inside of the kettle. After concentrating under reduced pressure at a temperature of ≦70°C, evaporate the solvent to dryness, then add 100kg of methanol and 1200kg of toluene into the kettle, and raise the temperature to reflux state and drop to 5°C The ganciclovir condensate is separated out, and the ganciclovir condensate is obtained by centrifugation. The centrifuged ganciclovir condensate mother liquor is returned to the kettle at a temperature ≦110°C, concentrated at normal pressure and then concentrated under reduced pressure, and methanol toluene is distilled off. Add 100kg of water to the bottom liquid in the still, so that the ga...

Embodiment 3

[0050] After the condensation reaction is finished, the reaction solution is preliminarily treated, cooled to room temperature, and isomers of the ganciclovir condensate are separated out, and the isomers of the ganciclovir condensate are centrifugally dried. Return the mother liquor of ganciclovir condensate isomer after centrifugation to the inside of the kettle. After concentrating under reduced pressure at a temperature of ≦70°C, evaporate the solvent to dryness, then add 100kg of methanol and 1200kg of toluene into the kettle, and raise the temperature to reflux state and drop to 5°C The ganciclovir condensate is separated out, and the ganciclovir condensate is obtained by centrifugation. The centrifuged ganciclovir condensate mother liquor is returned to the kettle at a temperature ≦110°C, concentrated at normal pressure and then concentrated under reduced pressure, and methanol toluene is distilled off. Add 100kg of water to the bottom liquid in the still, so that the g...

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Abstract

The invention discloses a method for recycling ganciclovir condensation compound synthesis mother liquor, which comprises the following steps: after the condensation reaction is finished, treating and separating out a ganciclovir condensation compound isomer, then evaporating the centrifugal mother liquor to dryness a solvent, and adding methanol and toluene to separate out a ganciclovir condensation compound; transferring the mother liquor after centrifuging the ganciclovir condensation compound into a reaction kettle to concentrate methanol and toluene; adding water into the base solution to separate out a ganciclovir condensation compound isomer, and centrifuging the ganciclovir condensation compound isomer; the recovered methanol toluene is directly used as toluene after being washed twice; the ganciclovir condensation compound isomer recovered from the mother liquor can also be put into the condensation reaction for continuous use; according to the method, resource recycling and limited resource waste are well achieved, and the method has large economic benefits and good social benefits.

Description

technical field [0001] The invention relates to the fields of chemical substance recovery, industrial energy saving and consumption reduction, and environmental protection, and relates to a method for recycling mother liquor in the production process of pharmaceutical intermediates, in particular to a method for recycling mother liquor for synthesizing ganciclovir condensate. Background technique [0002] With the continuous development of the chemical synthesis pharmaceutical industry, people pay special attention to the recovery and reuse of the reaction medium and raw materials produced in the pharmaceutical process. Extensive production and unreasonable post-processing waste limited resources, increase manufacturing costs and have a greater impact on environmental protection. [0003] Ganciclovir is a nucleoside antiviral drug that can competitively inhibit DNA polymerase and incorporate into the DNA of viruses and host cells, thereby inhibiting DNA synthesis. The produ...

Claims

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Application Information

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IPC IPC(8): C07D473/18
CPCC07D473/18
Inventor 汪宏福李晓晖杨明高宋鲜明喻莎莎胡江珍徐诚彭志鹏
Owner HUBEI HONGYUAN PHARMA
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