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Method for recovering side chain in ganciclovir condensation compound mother liquor

A technology of ganciclovir condensate and recovery method, applied in the field of industrial waste liquid treatment and recovery, can solve problems such as increasing raw material cost, environmental impact, waste of resources, etc., achieve good social benefits, reduce raw material cost, and realize resource recycling The effect of recycling

Pending Publication Date: 2022-01-14
HUBEI HONGYUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The amount of mother liquor produced after centrifugation of ganciclovir condensate is large, and it is directly treated as production waste liquid, which not only wastes resources, increases the cost of raw materials, but also has a certain impact on the environment

Method used

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  • Method for recovering side chain in ganciclovir condensation compound mother liquor
  • Method for recovering side chain in ganciclovir condensation compound mother liquor
  • Method for recovering side chain in ganciclovir condensation compound mother liquor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]Put 100kg of diacetylguanine, 30kg of ganciclovir condensate isomers, 100kg of ganciclovir side chains and 300kg of DMF into the reaction kettle, add 1kg of p-toluenesulfonic acid, and keep warm at 120-130°C for 45h. After the reaction was completed, the solvent was concentrated under reduced pressure, 800 kg of methanol was added to dissolve the residue, the solution was cooled to 25-30° C., and stirred for 3 hours to crystallize. Centrifuge, concentrate the centrifuged mother liquor under reduced pressure, dissolve the concentrated residue with a mixed solvent composed of 100kg methanol and 600kg toluene, and then cool to 5-10°C for crystallization for 2h. After centrifugation, the filtrate is pumped into a transfer kettle, and 100kg of water and 200kg of methanol are added to the transfer kettle, stirred for 45 minutes, and centrifuged. The filter cake is solid waste, the filtrate is transferred to the extraction kettle, stirred for 30 minutes, left to stand for 15 mi...

Embodiment 2

[0043] Put 100kg of diacetylguanine, 30kg of ganciclovir condensate isomers, 100kg of ganciclovir side chains and 300kg of DMF into the reaction kettle, add 1kg of p-toluenesulfonic acid, and keep warm at 120-130°C for 45h. After the reaction was completed, the solvent was concentrated under reduced pressure, 800 kg of methanol was added to dissolve the residue, the solution was cooled to 25-30° C., and stirred for 3 hours to crystallize. Centrifuge, concentrate the centrifuged mother liquor under reduced pressure, dissolve the concentrated residue with a mixed solvent composed of 100kg methanol and 600kg toluene, and then cool to 5-10°C for crystallization for 2h. After centrifugation, the filtrate is pumped into a transfer kettle, and 100kg of water and 200kg of methanol are added to the transfer kettle, stirred for 45 minutes, and centrifuged. The filter cake is solid waste, the filtrate is transferred to the extraction kettle, stirred for 30 minutes, left to stand for 15 m...

Embodiment 3

[0047] Put 100kg of diacetylguanine, 30kg of ganciclovir condensate isomers, 100kg of ganciclovir side chains and 300kg of DMF into the reaction kettle, add 1kg of p-toluenesulfonic acid, and keep warm at 120-130°C for 45h. After the reaction was completed, the solvent was concentrated under reduced pressure, 800 kg of methanol was added to dissolve the residue, the solution was cooled to 25-30° C., and stirred for 3 hours to crystallize. Centrifuge, concentrate the centrifuged mother liquor under reduced pressure, dissolve the concentrated residue with a mixed solvent composed of 100kg methanol and 600kg toluene, and then cool to 5-10°C for crystallization for 2h. After centrifugation, the filtrate is pumped into a transfer kettle, and 100kg of water and 200kg of methanol are added to the transfer kettle, stirred for 45 minutes, and centrifuged. The filter cake is solid waste, the filtrate is transferred to the extraction kettle, stirred for 30 minutes, left to stand for 15 m...

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Abstract

The invention discloses a method for recovering a side chain in ganciclovir condensation compound mother liquor, which comprises the following steps of: after the condensation reaction is finished, transferring mother liquor obtained after ganciclovir condensation compound centrifuging into a reaction kettle to concentrate methanol and toluene; adding water into the base solution to separate out a ganciclovir condensation compound isomer; adding water and toluene into mother liquor obtained after centrifuging of the ganciclovir condensation compound isomer, stirring and filtering, layering filtrate, taking a toluene layer, extracting a water layer twice with toluene, and merging the toluene layer; and then carrying out atmospheric distillation and vacuum rectification on toluene to obtain a ganciclovir side chain. By the implementation of the method, resource recycling is better realized, waste of limited resources is reduced, the raw material cost of ganciclovir is reduced, and great economic benefits and good social benefits are achieved.

Description

technical field [0001] The invention relates to the technical field of industrial waste liquid treatment and recovery, in particular to a method for recovering ganciclovir side chains in ganciclovir condensate mother liquor. Background technique [0002] With the development of the chemical and pharmaceutical industry, the treatment costs of a large amount of waste liquid generated by chemical and pharmaceutical companies in production have become one of the important production costs of the company. Due to the need to use a variety of raw materials in the process of pharmaceutical and chemical production, and the composition of waste liquid is extremely complex, medical waste liquid has become one of the more difficult waste liquids to treat. [0003] Ganciclovir is a nucleoside antiviral drug that can competitively inhibit DNA polymerase and incorporate into the DNA of viruses and host cells, thereby inhibiting DNA synthesis. The product was launched by the Syntex company...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C67/48C07C67/52C07C67/54C07C67/58C07C69/18C07D473/18
CPCC07C67/48C07C67/52C07C67/54C07C67/58C07D473/18C07C69/18
Inventor 汪宏福李晓晖杨明高宋鲜明徐诚喻莎莎胡江珍彭志鹏
Owner HUBEI HONGYUAN PHARMA
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