Strile absorbent sutures for gynaecology and obstetrics and preparation method of strile absorbent sutures

A technology of obstetrics and gynecology and sutures, applied in the field of medical sutures, can solve the problems of slow degradation of polylactic acid, restriction of tissue ingrowth, difficult suture performance regulation, etc., to promote ingrowth healing, good biophase Capacitance, the effect of avoiding secondary cracking

Active Publication Date: 2020-01-10
刘金娥 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the patent uses too many types of raw materials, and each raw material is simply mixed, and the effect is not clear, so it is difficult to effectively control the performance of the suture; at the same time, due to the slow degradation rate of polylactic acid, although it can maintain a high strength, However, the resulting suture continues to maintain a relatively tight structure inside, limiting tissue ingrowth, thereby prolonging the healing time and affecting the healing effect

Method used

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  • Strile absorbent sutures for gynaecology and obstetrics and preparation method of strile absorbent sutures
  • Strile absorbent sutures for gynaecology and obstetrics and preparation method of strile absorbent sutures
  • Strile absorbent sutures for gynaecology and obstetrics and preparation method of strile absorbent sutures

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preparation example Construction

[0034] The present invention also provides a preparation method of absorbable suture for obstetrics and gynecology, comprising the following steps:

[0035] S1, dissolving chitosan in a mixed solution containing acetic acid and urea, obtaining a spinning solution after filtering and degassing, and preparing chitosan threads by wet spinning;

[0036] S2. Mix lactic acid solution with polyethylene glycol solution, prepare polylactic acid by solution polycondensation method, then mix and heat the prepared polylactic acid and chitosan to obtain chitosan graft-modified polylactic acid, and use melting Modified polylactic acid yarns are prepared by spinning;

[0037] S3. Take 1 strand of chitosan thread obtained in step S1 as the core thread, and take 6 to 8 strands of the modified polylactic acid thread obtained in step S2 as the shell thread, and use a braiding machine to carry out ply braiding to obtain a braided thread;

[0038] S4. After mixing calcium stearate and polylactic ...

Embodiment 1

[0043] This embodiment provides a method for preparing absorbable suture for obstetrics and gynecology, comprising the following steps:

[0044] S1. The degree of deacetylation of 5g is 90%, and the relative molecular mass is >1.0×10 6 Chitosan is dissolved in the mixed solution that contains acetic acid and urea in 100g, and the massfraction of acetic acid is 5% in the described mixed solution, and the massfraction of urea is 2%; Make chitosan solution after fully stirring, then to After filtering and removing air bubbles, the spinning solution is obtained, which is sprayed out through a spinneret, and then coagulated and stretched to obtain chitosan threads with a diameter of 0.1 mm;

[0045] S2. Mix the lactic acid solution with a concentration of 88% and the polyethylene glycol solution with a concentration of 50% in a mass ratio of 1:1. 2 Heat the oil bath to 120°C under the atmosphere. After prepolymerization for 2 hours, add stannous octoate as a catalyst, then raise t...

Embodiment 2～4 and comparative example 1～2

[0058] Embodiments 2 to 4 and Comparative Examples 1 to 2 respectively provide a preparation method of absorbable sutures for obstetrics and gynecology. The number of strands of the wire; the corresponding core wire diameters, shell wire diameters and shell wire strands in each embodiment and comparative example are shown in Table 2.

[0059] Table 2 Corresponding core wire diameter, shell wire diameter and shell wire strands of Examples 2-4 and Comparative Examples 1-2

[0060] Example Core wire diameter(mm) Hull diameter (mm) Number of shell strands (shares) Example 2 0.2 0.12 8 Example 3 0.1 0.1 6 Example 4 0.2 0.2 6 Comparative example 1 0.1 0.06 3 Comparative example 2 0.1 0.06 12

[0061] The mechanical properties, antibacterial properties and degradation properties of the absorbable sutures for obstetrics and gynecology prepared in Examples 2-4 and Comparative Examples 1-2 were tested, and the results are shown...

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Abstract

The invention discloses strile absorbent sutures for gynaecology and obstetrics and a preparation method of the strile absorbent sutures. The strile absorbent sutures for the gynaecology and obstetrics are prepared by taking chitosan silk threads as core threads, taking modified polylactic acid silk threads as shell threads, after stranding braiding, immersing the chitosan silk threads and the modified polylactic acid silk threads into coating liquid containing calcium stearate and polylactic acid and drying the liquid. Through the preparation method, the mechanical properties and hydrophilicproperties of the polylactic acid can be improved, and the prepared sutures have high strength and good biocompatibility; chitosan in the inner part of the sutures degrades slowly, while long-term antibacterial action is achieved, the sutures can further gradually form a hollow structure, thus ingrowth and healing of tissue is promoted, and the effect of accelerating the healing of the tissue is achieved; and the overall preparation process is simple and convenient to control, and needs of practical production and application can be met.

Description

technical field [0001] The invention relates to the technical field of medical sutures, in particular to an absorbable suture for obstetrics and gynecology and a preparation method thereof. Background technique [0002] In the clinical diagnosis and treatment of obstetrics and gynecology, surgery plays an irreplaceable role, and suture, as one of the necessary materials for suturing incisions after surgery, is of great significance in accelerating incision healing and reducing postoperative complications. At present, sutures are generally divided into absorbable sutures and non-absorbable sutures. Among them, absorbable sutures are not only non-toxic, non-irritating, and highly compatible, but also have good biodegradability and can be degraded and absorbed by the human body. It is painful to remove the stitches and enhance the aesthetic effect of the operation, so it is widely used in clinical suture, especially in obstetrics and gynecology, to meet the needs of doctors and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/10A61L17/12A61L17/14
CPCA61L17/10A61L17/12A61L17/145A61L2400/18A61L2420/02
Inventor 王时灿
Owner 刘金娥
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