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Application of lncRNA HOXD-AS2 as diagnostic marker for gastric cancer

A technology for diagnosing markers and gastric cancer, applied in the field of medical biological detection, can solve problems such as unclear abnormal regulation of lncRNA signaling pathways, and achieve the effects of good translational medicine prospects, high sensitivity, and guaranteed reliability.

Active Publication Date: 2020-01-10
成都医学院第一附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still a large number of gastric cancer-associated lncRNAs that aberrantly regulate signaling pathways that remain unclear

Method used

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  • Application of lncRNA HOXD-AS2 as diagnostic marker for gastric cancer
  • Application of lncRNA HOXD-AS2 as diagnostic marker for gastric cancer
  • Application of lncRNA HOXD-AS2 as diagnostic marker for gastric cancer

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] The relative expression levels of lncRNA HOXD-AS2 in gastric cancer tissues and corresponding paracancerous tissues were tested, and the results were as follows: figure 1 It can be seen from the figure that the relative expression level of lncRNA HOXD-AS2 in gastric cancer tissues is significantly lower than that in corresponding paracancerous tissues.

Embodiment 2

[0073] The relative expression levels of lncRNA HOXD-AS2 in five gastric cancer cell lines AGS, MGC-803, SGC-7901, BGC-823, SNU-1 and normal gastric mucosal cell GES-1 were tested, and the results were as follows: figure 2 shown.

[0074] It can be seen from the figure that the relative expression level of HOXD-AS2 in gastric cancer cell lines AGS, MGC-803, SGC-7901, BGC-823 and SNU-1 was significantly lower than that in normal gastric mucosal cell GES-1.

Embodiment 3

[0076] The expression level of lncRNA HOXD-AS2 in 79 gastric cancer patients was detected, and the relationship between the expression level of lncRNA HOXD-AS2 and the clinical data of gastric cancer patients is shown in Table 1 below.

[0077] Table 1 The relationship between the expression level of lncRNA HOXD-AS2 and the clinicopathological features of patients with gastric cancer

[0078]

[0079]

[0080] The low expression of HOXD-AS2 was related to lymph node metastasis (P=0.009) and TNM stage (P=0.040), but was related to gender, age, smoking, drinking, tumor diameter, degree of differentiation, depth of tumor invasion, distant Metastasis, vascular invasion, nerve invasion, liver metastasis, ascites and fat nodule metastasis were all irrelevant (P>0.050).

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Abstract

The invention discloses application of lncRNA HOXD-AS2 as a diagnostic marker for gastric cancer, and relates to the technical field of medical bioassay. A gastric cancer diagnostic reagent or kit comprising a pair of specific detection primers is further constructed and used for detecting tissue specimens or blood samples such as plasma, serum and platelets. Good clinical application value is achieved, and better detection effect on the diagnosis of gastric cancer is achieved.

Description

technical field [0001] The invention belongs to the technical field of medical biological detection, and in particular relates to the application of lncRNA HOXD-AS2 as a diagnostic marker for gastric cancer. Background technique [0002] China is one of the countries with the highest incidence rate of gastric cancer. The new cases of gastric cancer account for more than 40% of the world. Gastric cancer is the third cause of malignant tumor mortality. In recent years, with the continuous improvement of diagnosis and treatment technology, although the mortality rate of gastric cancer has decreased and the prognosis has improved significantly, the 5-year survival rate of gastric cancer in large medical centers in my country has increased significantly. But relative to the Japanese data, there is still a considerable gap. How to effectively improve the diagnosis and treatment of gastric cancer has always been a hot and difficult issue for clinicians. Although the diagnosis and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886A61K31/7105A61K45/00A61P35/00
CPCC12Q1/6886A61K31/7105A61K45/00A61P35/00C12Q2600/158C12Q2600/178C12Q2600/112C12Q2600/136
Inventor 肖江卫罗雅军刘紫麟叶鹏程姚林黄清梅
Owner 成都医学院第一附属医院
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