Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Diagnostics of gingivitis based on salivary il-1beta and hgf

A technology of hepatocyte growth factor and gingivitis, applied in the field of oral care, can solve the problems that consumers cannot implement

Pending Publication Date: 2020-01-10
KONINKLJIJKE PHILIPS NV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is a labor-intensive process that is not performed by dentists on every patient and / or visit, and by consumers (self-diagnosis)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Diagnostics of gingivitis based on salivary il-1beta and hgf
  • Diagnostics of gingivitis based on salivary il-1beta and hgf
  • Diagnostics of gingivitis based on salivary il-1beta and hgf

Examples

Experimental program
Comparison scheme
Effect test

example

[0113] In a clinical study of 54 subjects, 25 of whom were diagnosed with gingivitis and 29 with healthy gingiva, the ROC (Receiver-Operator-Characteristic) curve-under-area ( AUC) value.

[0114] In statistics, a receiver operating characteristic curve or ROC curve is a graphical plot that illustrates the performance of a binary classifier system as the discriminative threshold is varied. Create a curve by plotting the true positive rate (TPR) versus the false positive rate (FPR) at various threshold settings. The true positive rate is also known in machine learning as sensitivity, recall, or probability of detection [1] . The false positive rate is also known as fall-out or false alarm [1] Probability, and can be calculated as (1-specificity). Thus, the ROC curve is a function of sensitivity as fall-out. In general, if the probability distributions for detection and false alarms are known, an ROC curve can be generated by plotting the cumulative distribution funct...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Disclosed is an in vitro method for assessing the presence of gingivitis in a human subject. The method is based on the insight to determine a selection of three biomarker proteins. Accordingly, in asaliva sample of the subject the concentrations are measured of the proteins Hepatocyte growth factor (HGF) and Interleukin-1 beta (IL-1beta), and at least one of C reactive protein (CRP) and Haemoglobin. Based on the concentrations as measured, a value is determined reflecting the joint concentrations for said proteins. This value is compared with a threshold value reflecting in the same manner the joint concentrations associated with the absence of gingivitis or periodontitis. The comparison allows to assessing whether the testing value is indicative of the presence of gingivitis in said subject. Thereby, typically, a testing value reflecting a joint concentration above the joint concentration reflected by the threshold, is indicative of the presence of gingivitis.

Description

technical field [0001] The present invention belongs to the field of oral care and relates to saliva-based diagnosis of periodontal disease. In particular, the present invention relates to kits and methods for determining the occurrence of gingivitis. Background technique [0002] Inflammation of the gums, or gingivitis, is a non-destructive periodontal disease mainly caused by plaque or plaque adhering to the tooth surface. If not detected and treated, reversible gingivitis usually results in inflammation of the tissues surrounding the teeth (i.e. the periodontium), a condition defined as periodontitis, which is irreversible and leads to tissue destruction and loss of alveolar bone, and eventually lead to tooth loss. During the development of gum disease, there are usually clinical symptoms and signs associated with it, such as swollen gums that change color from pink to dark red, bleeding gums, bad breath, and gums that become more tender or tender. [0003] Severe peri...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/72
CPCG01N33/6893G01N33/721G01N33/726G01N2333/4737G01N2333/4753G01N2333/545G01N2333/805G01N2800/18G16H10/40G01N2800/60
Inventor G·库伊杰曼M·A·范哈特斯坎普M·K·J·德加格A·H·里迈勒P·普雷肖J·J·泰洛尔
Owner KONINKLJIJKE PHILIPS NV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com