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Composition for promoting hair growth comprising escin

A technology of hair growth and composition, applied in the field of compositions for promoting hair growth, and can solve problems such as use restriction

Pending Publication Date: 2020-01-17
LG HOUSEHOLD & HEALTH CARE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many restrictions on the use of the above-mentioned preparations due to side effects or precautions in use

Method used

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  • Composition for promoting hair growth comprising escin
  • Composition for promoting hair growth comprising escin
  • Composition for promoting hair growth comprising escin

Examples

Experimental program
Comparison scheme
Effect test

manufacture example 1

[0061] Production example 1: Hair loss treatment / hair growth composition 1 (hair moisturizer)

[0062] According to the formulation shown in the following Table 1, the hair moisturizer of the Example and the comparative example containing aescin were produced by the usual method.

[0063] 【Table 1】

[0064]

manufacture example 2

[0065] Production example 2: Hair loss treatment / hair growth composition 2 (hair cream)

[0066] According to the recipe described in the following Table 2, a escin-containing hair cream (Example 7) was produced by a usual method.

[0067] 【Table 2】

[0068] Compounding ingredients weight ratio(%) Cetearyl Alcohol 2 Stearyl triethyl ammonium chloride 2 Hydroxyethyl cellulose 0.5 Aescin 2 Flavors and Colors Appropriate amount pure water Balance (total 100)

experiment example 1

[0069] Experimental example 1: Regulatory effect of dermal papilla cell activity signal (Wnt / β-catenin)

[0070] In general, activated wnt / β-catenin signaling in the dermal papilla occurs during the hair growth cycle transition from catagen to active phase, that is, the active phase from hair onset to hair growth. In addition, during the telogen and catagen phases, the wnt / β-catenin signal weakens or disappears, resulting in hair follicle degeneration and hair loss. In this experimental example, it was confirmed how much escin contributes to wnt / β-catenin signal amplification.

[0071] Wnt3a protein was used as a positive control group to amplify Wnt / β-catenin signal, and DMSO was used as a negative control group. In a culture 96-well plate, approximately 3x10 4The Wnt reporter HEK293A cells were seeded into each well, and then aescin was treated at concentrations of 5 μg / ml, 10 μg / ml, and 20 μg / ml, respectively. Then, reporter analysis was carried out using Promega's lucif...

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Abstract

The present invention relates to a composition for preventing hair loss and promoting hair regrowth, the composition comprising an ingredient for inducing anagen hair growth and hair growth promotionto promote the growth of hairs. The composition for preventing hair loss and promoting hair regrowth according to the present invention promotes hair regrowth by shortening the period of transition from the telogen stage to the anagen stage and delays the transition to catagen stage in the hair growth cycle, thereby exhibiting an excellent effect of preventing hair loss and promoting hair regrowth. In addition, the composition of the present invention is safe to the human body, with no side effects thereto, promotes the proliferation of dermal papilla cells, and has an excellent effect of increasing hair elasticity.

Description

technical field [0001] This application claims the priority of Korean Patent Application No. 10-2018-0079534 and Korean Patent Application No. 10-2018-0126283 filed on July 9, 2018. All the contents disclosed in the description and drawings of the application are quoted in this application. [0002] The present invention relates to a composition for promoting hair growth, and relates to an anti-hair loss and hair growth promoting composition for promoting hair growth containing a hair growth-inducing or hair growth-promoting component. Background technique [0003] Hair plays an important part in the increasing attention paid to beauty as the times change. Hair is a thin, keratinized structure that grows on the surface of the skin. It has a buffering effect on external shocks, protects the human body from external stimuli such as direct light, cold, friction, and danger, and performs the function of expelling heavy metals such as arsenic, mercury, and zinc that are harmful...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/63A61K8/60A61K8/368A61K8/35A61P17/14A61Q7/00
CPCA61K8/9789A61K8/63A61K8/602A61K8/368A61K8/355A61Q7/00A61P17/14A61K31/7034A61K31/122A61K31/704A61K31/192A61K2300/00A61K8/604
Inventor 申载永李相和
Owner LG HOUSEHOLD & HEALTH CARE LTD
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