Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of membrane protein ErbB4 in preparation of medicines for treating cerebral ischemic injury

A membrane protein, cerebral ischemia technology, applied in the field of molecular biology and biomedicine, can solve the problems of unclear cascade and network relationship, failure, complex pathological damage mechanism, etc., to inhibit behavioral changes, inhibit injury, promote Effects of cholesterol synthesis

Pending Publication Date: 2020-01-21
NANTONG UNIVERSITY
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pathological injury mechanism after cerebral ischemia is very complex, and the cascade and network relationship between various injury mechanisms is still unclear. The clinical trials of drug candidates developed for a certain target in the mechanism of cerebral ischemic injury have all failed

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of membrane protein ErbB4 in preparation of medicines for treating cerebral ischemic injury
  • Application of membrane protein ErbB4 in preparation of medicines for treating cerebral ischemic injury
  • Application of membrane protein ErbB4 in preparation of medicines for treating cerebral ischemic injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] In order to make the technical problems, technical solutions and advantages to be solved by the present invention clearer, the following will describe in detail in conjunction with specific embodiments.

[0017] The embodiment of the present invention provides the application of membrane protein molecule ErbB4 in the preparation of medicines for the treatment of cerebral ischemic injury, including the following aspects: establishing an injury model, and performing drug treatment for the preparation of membrane protein molecule ErbB4 on the injury model, that is, promoting the total amount of ErbB4 in the injury model. Expression and activity, can inhibit ischemic damage to neurons.

[0018] The embodiment of the present invention further provides a drug for treating cerebral ischemic injury, including the regulatory protein NRG1 that promotes the total expression and activity of the membrane protein molecule ErbB4.

[0019] The embodiment of the present invention also p...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Relative molecular massaaaaaaaaaa
Relative molecular massaaaaaaaaaa
Login to View More

Abstract

The invention provides application of a membrane protein molecule ErbB4 in preparation of medicines for treating of cerebral ischemic injury. The application comprises the following steps: establishing an injury model, AND performing treatment on the injury model by using a medicine prepared from a membrane protein molecule ErbB4, that is, promoting total expression and activity of ErbB4 in the injury model, and inhibiting injury of ischemia to neurons. The invention further provides a medicine for treating cerebral ischemic injury. The medicine comprises a regulatory protein NRG1 for promoting total expression and activity of the membrane protein molecule ErbB4. The invention further provides a method for promoting total expression and activity of the membrane protein molecule ErbB4. Themethod comprises the following processes: (1) establishing a cerebral ischemia model; (2) observing total expression and active fragment expression of ERBB4 in the cerebral ischemia model; (3) confirming whether the activity and expression regulation of the membrane molecule ErbB4 can affect cholesterol synthesis or not; and (4) adding NRG1 in the cerebral ischemia model to promote total expression and activity of ERBB4. The application provided by the invention inhibits injury of ischemia to neurons and has a protection function on cerebral ischemic injury.

Description

technical field [0001] The invention belongs to the fields of molecular biology and biomedicine, and specifically relates to the application of membrane protein molecule ErbB4 in the preparation of medicines for treating cerebral ischemia injury, the medicine for treating cerebral ischemia injury, and the method for promoting the total expression and activity of membrane protein molecule ErbB4. Background technique [0002] According to the statistics of the "China Stroke Prevention Report (2018)", in the past 30 years, the incidence of stroke in my country has risen sharply, and it has shown rapid growth among low-income groups, obvious gender and regional differences, and younger trends. The report pointed out that the stroke prevention project is urgent, and the scientific research content of stroke prevention work must be further strengthened. [0003] Ischemic stroke accounts for about 80% of stroke patients. Ischemic stroke refers to the sudden decrease in blood perfu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12Q1/6883G01N33/68A61K38/18A61P9/10A61P25/00
CPCC12Q1/6883G01N33/6893A61K38/1883A61P9/10A61P25/00G01N2800/2871
Inventor 陈霞魏金环周雪莉王守艳
Owner NANTONG UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com