A kind of polysaccharide prebiotic and its preparation method and application

A prebiotic and polysaccharide technology, which is applied in pharmaceutical formulas, medical preparations containing active ingredients, and digestive systems, can solve the problems of single formula components and insignificant effect of intestinal flora, and achieves a simple extraction method and improved Balanced, high extraction efficiency

Active Publication Date: 2022-07-01
南京卫士药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention overcomes the disadvantages of prebiotics in the prior art that its formula components are relatively single and its effect on regulating intestinal flora is not obvious, and provides a polysaccharide prebiotic that can effectively regulate the growth of beneficial flora in the intestinal tract and its Its preparation method and application

Method used

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  • A kind of polysaccharide prebiotic and its preparation method and application
  • A kind of polysaccharide prebiotic and its preparation method and application
  • A kind of polysaccharide prebiotic and its preparation method and application

Examples

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Comparison scheme
Effect test

Embodiment 1

[0037] A preparation method of polysaccharide prebiotics, the method comprises the following steps:

[0038] (1) Degreasing: pulverize Usnea longa to 100 mesh and place it in acetone to reflux for degreasing for 8 hours, filter and dry the filter residue at 70°C to obtain dry degreasing Usnea longa powder;

[0039] (2) Freeze wall breaking: add a certain amount of water to the dry defatted usnea powder, the mass ratio of usnea powder to water is 1:0.5, and then immerse the wet degreasing usnea powder in liquid nitrogen Quickly freeze, take out and apply 10MPa static pressure to it for 3 times, then dry to obtain broken-wall usnea powder;

[0040] (3) Enzymatic hydrolysis and water extraction: according to the mass ratio of 1:10, the broken usnea powder was placed in distilled water, and enzymatically hydrolyzed at 55 ° C for 6 hours. The enzyme used for enzymatic hydrolysis was cellulase, and the amount of cellulase added was 2.5% of the mass of the solution, after enzymatic ...

Embodiment 2

[0046] A preparation method of polysaccharide prebiotics, the method comprises the following steps:

[0047] (1) Degreasing: pulverize Usnea longa to 300 mesh and place it in acetone to reflux for degreasing for 24h, filter and dry the filter residue at 85°C to obtain dry degreasing Usnea longa powder;

[0048](2) Freeze wall breaking: add a certain amount of water to the dry defatted usnea powder, and the mass ratio of the usnea powder to water is 1:2.5, and then immerse the wet defatted usnea powder in liquid nitrogen Quickly freeze, take out and apply 16MPa static pressure to it for 5 times, and then dry to obtain broken-wall usnea powder;

[0049] (3) Enzymatic hydrolysis and water extraction: according to the mass ratio of 1:20, the broken usnea powder was placed in distilled water, and enzymatically hydrolyzed at 55 ° C for 6 hours. The enzyme used for enzymatic hydrolysis was cellulase, and the amount of cellulase added was 2.5% of the mass of the solution, after enzym...

Embodiment 3

[0055] A preparation method of polysaccharide prebiotics, the method comprises the following steps:

[0056] (1) Degreasing: pulverize Usnea longa to 200 mesh and place it in acetone to reflux for degreasing for 12 hours, filter and dry the filter residue at 80°C to obtain dry degreasing Usnea longa powder;

[0057] (2) Freeze wall breaking: add a certain amount of water to the dry defatted usnea powder, the mass ratio of the usnea powder to water is 1:1.5, and then immerse the wet defatted usnea powder in liquid nitrogen Quickly freeze, take out and apply 15MPa static pressure to it for 4 times, and then dry to obtain broken-wall usnea powder;

[0058] (3) Enzymatic hydrolysis and water extraction: according to the mass ratio of 1:20, the broken usnea powder was placed in distilled water, and enzymatically hydrolyzed at 50 ° C for 4 hours. The enzyme used for enzymatic hydrolysis was cellulase, and the amount of cellulase added was 1% of the mass of the solution, after enzym...

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Abstract

The invention relates to the field of polysaccharide compounds, in particular to a polysaccharide prebiotic and a preparation method and application thereof. The polysaccharide prebiotic contains in weight percentage: 10-15% of mannose; 1-5% of rhamnose; 35-60% of glucose; 25-40% of galactose; and 1-5% of xylose. The polysaccharide prebiotics are obtained by degreasing, freezing and breaking walls, enzymatic hydrolysis and water extraction and purification in sequence. The present invention overcomes the defects that the prebiotics in the prior art have relatively single formulation components and the effect of regulating intestinal flora is not obvious, can effectively regulate the number of beneficial bacteria and harmful bacteria in the intestinal tract, and improves the The advantages of the balance of the flora in the human intestine are simple, and the extraction efficiency is high.

Description

technical field [0001] The invention relates to the field of polysaccharide compounds, in particular to a polysaccharide prebiotic and a preparation method and application thereof. Background technique [0002] Intestinal flora, normal microorganisms in the human intestine, such as bifidobacteria, lactobacilli, etc., can synthesize a variety of vitamins necessary for human growth and development, such as B vitamins (vitamins B1, B2, B6, B12), vitamin K, tobacco It can also use protein residues to synthesize essential amino acids, such as aspartic acid, phenylalanine, valine and threonine, etc., and participate in the metabolism of carbohydrates and proteins, and can also promote iron, Absorption of minerals such as magnesium and zinc. These nutrients play an important role in human health, and if they are lacking, they will cause a variety of diseases. [0003] Therefore, the existence of intestinal flora is closely related to human health. The most important way in the p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7004A61P1/00
CPCA61K31/7004A61P1/00A61K2300/00
Inventor 陈荫王腾董喆孙坤来赵玉勤王斌
Owner 南京卫士药业有限公司
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