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Broad-spectrum antibacterial agent and preparation method thereof

A technology of antibacterial agent and lysozyme, applied in the field of antibacterial agent and its preparation, can solve problems such as poor antifungal activity, and achieve the effects of strong penetration and solubility, excellent antibacterial performance, and safe and simple operation.

Pending Publication Date: 2020-02-11
SHIJIAZHUANG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polyhexamethyleneguanidine (PHMG) has good antibacterial activity, high safety, non-toxic and harmless, but its antifungal activity is poor

Method used

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  • Broad-spectrum antibacterial agent and preparation method thereof
  • Broad-spectrum antibacterial agent and preparation method thereof
  • Broad-spectrum antibacterial agent and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0033] Crush garlic bulbs to extract allicin, lay it flat in the air and let it stand for 15 minutes to oxidize and decompose it into various oil-soluble organic sulfur compounds (OSCs). It mainly includes sulfide compounds such as diallyl monosulfide, diallyl disulfide, diallyl trisulfide and diallyl tetrasulfide. Take by weighing the purified allicin 25g and be dissolved in 200mL ethanol, add the oxidizing agent potassium peroxide (K 2 o 2 ), stirring continuously at 50°C for 2.5h. After the reaction, the ethanol solvent was removed by distillation under reduced pressure to obtain the modified allicin.

[0034] Add 100 mL of deionized water to the reaction kettle, and then add 2 g of polyethylene glycol (PEG), 0.5 g of sodium dodecylbenzenesulfonate, and 2.5 g of polyoxyethylene sorbitan fatty acid ester. Stir for 10 min, then add 2 g of lysozyme, and stir for 10 min. Then 2 g of fatty amine salt, 1 g of ethanolamine salt and 1 g of polyethylene polyamine salt were added...

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Abstract

The invention discloses an antibacterial agent and a preparation method thereof. The main antibacterial effective component of garlicin, namely a diallyl sulfide type composition is extracted, then the diallyl sulfide type composition is oxidized to improve water solubility to obtain modified garlicin, and then the modified garlicin and polyhexamethyleneguanidine (PHMG) are subjected to co-blending and modification. Water is used as a solvent, through various addition agents of a compatibilizer, a surfactant and the like, the modified garlicin and the polyhexamethyleneguanidine achieve good mutual dissolving and coblending effects, through synergistic reactions, high-efficiency durable antibacterial effects can be achieved, and the antibacterial agent is suitable for various bacteria and fungi.

Description

technical field [0001] The invention belongs to the technical field of additives, and more specifically relates to an antibacterial agent and a preparation method thereof. Background technique [0002] Guanidine polymers are mainly used as antibacterial agents because they contain guanidine functional groups. This is because the guanidine group has a great use in antibacterial, because the guanidine group can form a very stable eight-membered ring with the phosphate in the bacterial phospholipid, so it can penetrate the cell membrane. Polyhexamethyleneguanidine hydrochloride (PHMG) has been widely studied due to its good solubility in water, broad-spectrum antibacterial properties, good biocompatibility and non-toxicity. Polyhexamethyleneguanidine (PHMG) has good antibacterial activity, high safety, non-toxic and harmless, but its antifungal activity is poor. [0003] Organosulfur compounds (OSCs) have developed rapidly as antifungal drugs, including: thiourea compounds, t...

Claims

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Application Information

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IPC IPC(8): A61K31/255A61K31/785A61P31/04A61P31/10A61P35/00
CPCA61K31/255A61K31/785A61K2300/00
Inventor 王娟梁芳慧南紫萱岳琳张文英张伟亮贾鹏飞葛凤燕张星辰刘占旗邢云立章柏宁
Owner SHIJIAZHUANG UNIVERSITY
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