Glabrous greenbrier rhizome refined polysaccharide and preparation method thereof
A technology of Smilax cocos and polysaccharides, which is applied in the field of pharmacy, can solve the problems of limited industrialization value, and achieve the effect of strong reducing power measurement and high yield
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[0022] A method for preparing refined polysaccharides from Smilax glabra, comprising the following steps: S1, degreasing the dried smilax glabra decoction pieces with 5 to 8 times the amount of ethanol for heating, condensing and refluxing for 2 to 3 times; S2, using 5~ Extract 3 times with 8 times the amount of water, at a temperature of 80-100℃, 2h each time. After concentrating the water extract under reduced pressure, add absolute ethanol to the alcohol content of 80-85%, let stand for 24h, and discard the supernatant S3. Reconstitute the crude polysaccharide of Smilax glabra and add pepsin to the content of 0.1~0.4%. In a constant temperature water bath at 37℃ for 12h, remove the precipitate, repeat 3 times, and collect the upper layer. Concentrate the solution, add Sevage reagent, shake vigorously for 30 minutes, let stand for 12 hours, collect the upper polysaccharide solution, and repeat until there is no characteristic absorption peak of protein in the UV scan; S4. Conc...
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[0075] Example one:
[0076] Take 2g of refined polysaccharide from Poria cocos, 4g of hypromellose, 10g of sodium starch glycolate, 10g of microcrystalline cellulose, 115g of lactose, 50g of medicinal starch, and 1g of iron stearate. Mix the main medicine and auxiliary materials thoroughly and put them in In a high-speed mixer, spray an appropriate amount of water, granulate the granules, control the moisture content at 3 to 4%, and then press the tablets each month to make 1000 tablets and coat them with film. Each tablet contains 0.2mg of the main ingredient. The tablet is an antioxidant product or a neuroprotective product.
Example Embodiment
[0077] Embodiment two:
[0078] Smilax glabra refined polysaccharide 3g, sodium starch glycolate 15g, microcrystalline cellulose 15g, medicinal lake 50g, magnesium stearate 2g, mix the main medicine and auxiliary materials thoroughly and put them into a high-speed mixer, spray and add appropriate amount of water, and granulate. The water is controlled at 3-4%, and then compressed to make 1000 tablets. Each tablet contains 0.3mg of the main ingredient. The tablet is a chemical or neuroprotective product.
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