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Glabrous greenbrier rhizome refined polysaccharide and preparation method thereof

A technology of Smilax cocos and polysaccharides, which is applied in the field of pharmacy, can solve the problems of limited industrialization value, and achieve the effect of strong reducing power measurement and high yield

Inactive Publication Date: 2020-02-18
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These data are all about crude polysaccharides, with limited industrial value

Method used

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  • Glabrous greenbrier rhizome refined polysaccharide and preparation method thereof
  • Glabrous greenbrier rhizome refined polysaccharide and preparation method thereof
  • Glabrous greenbrier rhizome refined polysaccharide and preparation method thereof

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preparation example Construction

[0022] A method for preparing refined polysaccharides of Smilax cocos, comprising the following steps: S1, heating and condensing dried Smilax tuckahoe pieces with 5 to 8 times the amount of ethanol for 2 to 3 times to degrease; S2, degreasing the degreased medicinal residues 8 times the amount of water extraction 3 times, the temperature is 80 ~ 100 ° C, 2 hours each time, after the water extract is concentrated under reduced pressure, add absolute ethanol until the alcohol content reaches 80 ~ 85%, let it stand for 24 hours, discard the supernatant solution, collect the precipitate, and obtain the crude polysaccharide of Smilax smilax; S3, redissolve the crude polysaccharide of Smilax smilax, add pepsin to the content of 0.1-0.4%, and keep it in a constant temperature water bath at 37°C for 12 hours to remove the precipitate, repeat 3 times, and collect the upper layer Solution, concentrate, add Sevage reagent, shake vigorously for 30min, let stand for 12h, collect the polysa...

Embodiment 1

[0076] Take 2g of Smilax polysaccharide, 4g of hypromellose, 10g of sodium starch glycolate, 10g of microcrystalline cellulose, 115g of lactose, 50g of medicinal starch, and 1g of iron stearate; In a speed mixer, spray an appropriate amount of water, granulate, and control the water content at 3-4%, and then tablet monthly to make 1000 tablets, and coat with film. Each tablet contains 0.2mg of the main ingredient. The tablet is an antioxidant product or a neuroprotective product.

Embodiment 2

[0078] Smilax tuckahoe refined polysaccharide 3g, carboxymethyl starch sodium 15g, microcrystalline cellulose 15g, medicinal starch 50g, magnesium stearate 2g, the main drug and auxiliary materials are fully mixed and then put into a high-speed mixer, sprayed with appropriate amount of water, granulated, The water is controlled at 3-4%, and then pressed into tablets to make 1000 tablets. Each tablet contains 0.3mg of the main ingredient. The tablet is an antioxidant product or a neuroprotective product.

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Abstract

The invention relates to the technical field of pharmacy, in particular to a glabrous greenbrier rhizome refined polysaccharide and a preparation method thereof. The molecular weight of the glabrous greenbrier rhizome refined polysaccharide is 2.16*10<5>Da, and the glabrous greenbrier rhizome refined polysaccharide is composed of galactose, mannose, arabinose and glucose. The preparation method ofthe glabrous greenbrier rhizome refined polysaccharide comprises the specific steps that glabrous greenbrier rhizome decoction pieces are taken, non-sugar impurities in a crude polysaccharide are removed through Sevage method deproteinization, XAD-16 resin depigmentation and other methods, and an ion exchange DEAE FAST FLOW chromatographic column and a Superdex-200 gel chromatographic column areadopted to perform further separation and purification, so thatthe glabrous greenbrier rhizome refined polysaccharide is obtained. The glabrous greenbrier rhizome refined polysaccharide prepared through the method is a uniform polysaccharide, is high in yield, has oxidation resistance and neuroprotective activity, can eliminate DPH free radicals and ABST+, is strong in reducing power determinationand can be used for preparing an antioxidant and a neuroprotective preparation.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a refined polysaccharide of Smilax smilax and a preparation method thereof. Background technique [0002] Rhizoma Smilacis Glabrae is the dry rhizome of Liliaceae Smilacis glabrae. It is sweet, light, flat in nature, and has the effects of detoxification, dehumidification, and tonifying joints. It is mainly used to treat damp-heat stranguria, vaginal discharge, scrofula, scabies, syphilis and mercury poisoning. .Research progress on clinical application of Smilax smilax [J]. Asia-Pacific Traditional Medicine, 2017, 13(17): 77-78; National Pharmacopoeia Committee. Pharmacopoeia of the People's Republic of China (2015 Edition) Part One [M]. China Science and Technology Medical Press, 2015: 8). Smilax polysaccharide is one of the important active ingredients of Smilax smilax. It has a wide range of pharmacological effects, such as anti-oxidation, anti-tumor, immune regulation, an...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P39/06A61P25/00
CPCA61K31/715A61P25/00A61P39/06C08B37/0003C08B37/006
Inventor 朱伟袁小红黄海定
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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