Method for developing intelligent cancer drug

A drug and intelligent technology, applied in the field of biomedicine, can solve the problems of poor drug effect and poor targeting ability of targeted drugs, and achieve the effect of improving the ability to induce differentiation, easy to popularize and use, and maintain drug activity.

Pending Publication Date: 2020-02-28
上海英南智能技术发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problems existing in the prior art, the purpose of the present invention is to provide a method for developing smart cancer drugs, which has the advantage of targeting ability, and solves the problem that the existing targeted drugs have weak targeting ability and the drug effect is not good question

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A method for developing smart cancer drugs, comprising the following steps:

[0033] Step 1. Accurately weigh a certain proportion of dipalmitoylphosphatidylcholine, cholesterol, biotin-phthalated polyethylene glycol 2000-distearate phosphatidylethanolamine, DSPE-PEG2000-iRGD, paclitaxel, lecithin, soluble Proteins, targeting peptides, soluble metal salts;

[0034] Step 2, dissolving dipalmitoylphosphatidylcholine, cholesterol, biotin-phthalated polyethylene glycol 2000-distearate phosphatidylethanolamine, DSPE-PEG2000-iRGD, paclitaxel, and lecithin in an organic solvent to prepare Mix solution A, stand-by;

[0035] Step 3, soluble protein, targeting polypeptide, and soluble metal salt are respectively dissolved in water to prepare mixed solution B;

[0036] Step 4: Add the mixed solution B to the mixed solution A, vortex and oscillate for 10 minutes, and use ultrasonic waves with a frequency of 80 kHz for 25 minutes to obtain solution C;

[0037] Step 5. After seali...

Embodiment 2

[0050] A method for developing smart cancer drugs, comprising the following steps:

[0051] Step 1. Accurately weigh a certain proportion of dipalmitoylphosphatidylcholine, cholesterol, biotin-phthalated polyethylene glycol 2000-distearate phosphatidylethanolamine, DSPE-PEG2000-iRGD, paclitaxel, lecithin, soluble Proteins, targeting peptides, soluble metal salts;

[0052] Step 2, dissolving dipalmitoylphosphatidylcholine, cholesterol, biotin-phthalated polyethylene glycol 2000-distearate phosphatidylethanolamine, DSPE-PEG2000-iRGD, paclitaxel, and lecithin in an organic solvent to prepare Mix solution A, stand-by;

[0053] Step 3, soluble protein, targeting polypeptide, and soluble metal salt are respectively dissolved in water to prepare mixed solution B;

[0054] Step 4: Add the mixed solution B to the mixed solution A, vortex, 12.5min, and ultrasonic wave at a frequency of 100kHz for 30min to obtain solution C;

[0055] Step 5. After sealing solution C, stir and heat in ...

Embodiment 3

[0068] A method for developing smart cancer drugs, comprising the following steps:

[0069] Step 1. Accurately weigh a certain proportion of dipalmitoylphosphatidylcholine, cholesterol, biotin-phthalated polyethylene glycol 2000-distearate phosphatidylethanolamine, DSPE-PEG2000-iRGD, paclitaxel, lecithin, soluble Proteins, targeting peptides, soluble metal salts;

[0070] Step 2, dissolving dipalmitoylphosphatidylcholine, cholesterol, biotin-phthalated polyethylene glycol 2000-distearate phosphatidylethanolamine, DSPE-PEG2000-iRGD, paclitaxel, and lecithin in an organic solvent to prepare Mix solution A, stand-by;

[0071] Step 3, soluble protein, targeting polypeptide, and soluble metal salt are respectively dissolved in water to prepare mixed solution B;

[0072] Step 4: Add the mixed solution B to the mixed solution A, vortex and oscillate for 15 minutes, and use ultrasonic waves with a frequency of 120 kHz for 35 minutes to obtain solution C;

[0073] Step 5. After seal...

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PUM

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Abstract

The invention discloses a method for developing an intelligent cancer drug, which belongs to the field of biomedicine and is a method for developing the intelligent cancer drug. According to the scheme, the drug is specifically activated in tumor tissues through design modification, so that systemic toxic diseases of the drug are reduced to widen the treatment window of the drug; tissue specificity is utilized to improve the targeting property of the drug, so that the induced differentiation capability of differentiated drugs on tumor cells is improved, or the toxicity of anticancer drugs on cancer cells is improved; and a liposome is taken as a drug carrier, so that the drug has the advantages of maintaining the drug activity, enhancing the drug solubility, reducing the effect on normal tissues and the like. The technology can be applicable to auxiliary targeted treatment of multiple cancers, and has a wide application prospect.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a method for developing smart cancer drugs. Background technique [0002] According to the statistics of the World Health Organization (World Health Organization), cancer is the first or second leading cause of death before the age of 70 in 91 countries. The morbidity and mortality of cancer in China have been on the rise. Cancer has become the leading cause of death since 2010, accounting for 23.91% of all deaths among Chinese residents, and it has become the most important public health problem in China. In the past 10 years, the incidence and mortality of cancer in China have been increasing year by year. The average annual increase of cancer incidence is about 3.9%, and the average annual death rate is 2.5%. Therefore, malignant tumors are major diseases that endanger people's lives and health. Anticancer drugs Research and development has a long way to go. [0003] In ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K47/42A61K47/24A61K31/704A61K31/203A61K31/7048A61P35/00
CPCA61K9/127A61K47/42A61K47/24A61K31/704A61K31/203A61K31/7048A61P35/00
Inventor 田国栋田玉苗
Owner 上海英南智能技术发展有限公司
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