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Device for stimulating habenula nucleus and/or striae medullares and/or fasciculus retroflexus in brain

A technology of habenula and stimulation signal, applied in the direction of internal electrodes, artificial respiration, treatment, etc., can solve the problems of inability to clinical application, scattered experimental results, and unsatisfactory effects.

Pending Publication Date: 2020-03-10
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Experiments have proved that stimulating these parts can indeed achieve antidepressant effects, but the effect is not ideal, and the experimental results are scattered and cannot be applied clinically.

Method used

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  • Device for stimulating habenula nucleus and/or striae medullares and/or fasciculus retroflexus in brain
  • Device for stimulating habenula nucleus and/or striae medullares and/or fasciculus retroflexus in brain
  • Device for stimulating habenula nucleus and/or striae medullares and/or fasciculus retroflexus in brain

Examples

Experimental program
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Effect test

Embodiment 1

[0088] This embodiment provides a method for using an implantable deep brain stimulation system to stimulate the habenula (Hb) in the brain to treat psychiatric diseases. The implantable deep brain stimulation system includes electrodes, leads and a pulse generator. Methods include:

[0089] Step S101: placing at least one electrode in at least one side of the habenula, so that at least one contact point of the electrode is in the habenula area; the electrode can transmit a stimulation signal parallel to the axon to the habenula;

[0090] Step S102: connecting the electrode to at least one lead, and connecting the end of the lead to a pulse generator;

[0091] Step S103: use a pulse generator to generate a stimulation signal and transmit it to the contact of the electrode through a wire;

[0092] Step S104: regulating the neural activity of the electrode through the part of the electrode in the habenula.

[0093] In a preferred embodiment, the method is capable of preventing...

Embodiment 2

[0101]The present embodiment provides a method for treating psychiatric diseases by stimulating the stria medulla (SMT) upstream of the habenula with an implantable deep brain stimulation system, the implantable deep brain stimulation system comprising electrodes, leads and A pulse generator, the method comprising:

[0102] Step S201: placing at least one electrode at any position along the striae; the electrode can transmit a stimulation signal parallel to the fiber bundle to the striae;

[0103] Step S202: connecting the electrode to at least one wire, and connecting the end of the wire to the pulse generator;

[0104] Step S203: use a pulse generator to generate a stimulation signal and transmit it to any contact of the electrode through a wire;

[0105] Step S204 : adjust the neural activity of the electrode part near the stria medulla.

[0106] Preferably, the implantable deep brain stimulation system is capable of stimulating one side and / or bilateral areas of the stri...

Embodiment 3

[0115] This embodiment provides a method for treating psychiatric diseases by stimulating the posterior flexion (FR) of the fiber bundle downstream of the habenula in the brain with an implantable deep brain stimulation system, the implantable deep brain stimulation system comprising electrodes, wires and A pulse generator, the method comprising:

[0116] Step S301 : placing at least one electrode at any position along the posterior flexion bundle; the electrode can transmit a stimulation signal parallel to the fiber bundle to the posterior flexural bundle;

[0117] Step S302: connect the electrode to at least one wire, and connect the end of the wire to the pulse generator;

[0118] Step S303: use a pulse generator to generate a stimulation signal and transmit it to any contact of the electrode through a wire;

[0119] Step S304: Adjust the nerve activity of the posterior flexor through the electrode part near the posterior flexor.

[0120] In a preferred embodiment, the me...

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Abstract

The invention provides a device and method for stimulating habenula nucleus and / or striae medullares and / or fasciculus retroflexus in a brain to treat mental diseases. The method includes the following steps: at least one electrode is placed in the habenula nucleus located at least one side, and / or in any part of the striae medullares and / or the fasciculus retroflexus, at least one contact point of the electrode is in the area, the electrode is connected to at least one conductor, a terminal conductor is connected to a pulse generator, the electrode can transmit a stimulation signal parallel to an axon to the area, the pulse generator sends the stimulation signal to any contact points of the electrode through the conductor, and the electrode part in the area regulates the nerve activity. The device and method realize the stimulation of the habenula nucleus and / or upstream and downstream fiber bundles by using at least one electrode, and realize the feasibility of using a deep brain stimulation system to treat the mental diseases such as depression and addiction behaviors.

Description

technical field [0001] The invention relates to a device for stimulating the habenula and / or stria medulla and / or posterior flexion bundles by a deep brain stimulation system, and belongs to the technical field of implantable medical systems. Background technique [0002] The electrical activity of habenula neurons is closely related to depression, addictive behavior, obsessive-compulsive disorder and other psychiatric diseases. [0003] Neuropsychiatric diseases have become the world's largest disease, and it is increasing year by year, with a heavy burden on society and families. Taking depression as an example, depression has become the second largest disease in the world, with a prevalence rate as high as 14.6% in developed countries and 11.1% in non-developed countries, seriously endangering the physical and mental health of the public. [0004] Implantable deep brain stimulation systems have been developed and applied to the treatment of various diseases, such as Park...

Claims

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Application Information

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IPC IPC(8): A61N1/36A61N1/05
CPCA61N1/36082A61N1/36125A61N1/0534
Inventor 王志燕田野李路明
Owner TSINGHUA UNIV
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