50 results about "Brain deep stimulation" patented technology

A method of treating a target region in the brain includes a) contacting tissue to be stimulated with a lead of a stimulation device, the stimulation device comprising a pulse generator coupled to the lead, the lead having a plurality of segmented electrodes disposed at a distal end of the lead, the stimulation device being configured and arranged to stimulate a target region using a positionable centroid of stimulation; b) providing stimulation current to at least one of the segmented electrodes of the lead to generate a centroid of stimulation at a location and stimulate tissue around the location of the centroid of stimulation; c) repositioning the centroid of stimulation to a next location along a helical path by altering the provision of stimulation current to the plurality of electrodes and stimulating tissue around the location of the repositioned centroid of stimulation; and d) repeating c) for each location along the helical path. The method may optionally include collecting data associated with each of the locations of the centroid of stimulation; and displaying at least a portion of the collected data.

A method and apparatus for treating persons suffering from an eating disorder includes direct or indirect stimulation of selected areas of the brain associated with a symptom of the eating disorder. The stimulation regimen is programmable to enable physician optimization of stimulation signal parameters to ameliorate at least one symptom of bulimia or another eating disorder. Certain embodiments employ deep brain stimulation and / or sensing together with cranial nerve stimulation and / or sensing.

The invention discloses a percutaneous closed-loop control charging device for implantation type medical treatment instrument and belongs to the technical field of implantation medical instrument. The percutaneous closed-loop control charging device for implantation type medical treatment instrument comprises an external charger and an internal implantation type medical instrument. An external energy transmitting coil is a large-size flat magnetic core coil, and an internal energy receiving coil is a hollow coil; the external energy transmitting coil transmits electromagnetic energy by adopting a resonance electromagnetic coupling manner with parallel central shafts; and the electrical energy obtained by the internal energy receiving coil charges an internal rechargeable battery through an internal charge control circuit. The closed-loop control charging device communicates in a pulse position modulation manner for closed-loop control to ensure the energy received by the implantation medical instrument in different charging phases to be within the normal range, effectively control the heating and increase the safety; the closed-loop control charging device calculates the efficiency by the internal feedback parameter to realize counterpoint prompt and increase the charging efficiency. The percutaneous wireless charging method can charge the implantation type medical instrument by a titanium casing, is safe and reliable in charging, and can be applied to all types of implantation type medical instruments equivalent to a deep brain stimulator in power level.

A deploying deep brain stimulating probe with a shaft, at least one opening on said shaft, at least one extendable tendril, said tendril deploying from said shaft into surrounding tissue through said opening and an electrode disposed on said tendril.

A method of optimal placement of a deep brain stimulator in a targeted region of a brain of a living subject for optimal deep brain stimulation. In one embodiment, the method includes the steps of nonmanually selecting an initial optimal position from, refining the nonmanually selected initial optimal position to determine a final position, and placing the deep brain stimulator at the final position in the targeted region of the brain of the living subject.

A method and apparatus for treating persons suffering from an eating disorder includes direct or indirect stimulation of selected areas of the brain associated with a symptom of the eating disorder. The stimulation regimen is programmable to enable physician optimization of stimulation signal parameters to ameliorate at least one symptom of bulimia or another eating disorder. Certain embodiments employ deep brain stimulation and / or sensing together with cranial nerve stimulation and / or sensing.

The invention discloses a rechargeable stimulator for deep parts of brain, which comprises an electrical energy transforming apparatus, an exterior control monitoring apparatus outside human body and a stimulation impulse generator implanted into hypodermal of human body, wherein the electric energy transforming apparatus is used to generate high-frequency resonant electromagnetic field, the high-frequency resonant electromagnetic field penetrates human body skin and conveys electrical energy to the stimulation impulse generator, which includes an electric energy coupling module for receiving the high-frequency resonant electromagnetic field and transform it into electric energy, wherein the power supply regulating module provide electrical source to the stimulation pulse generator.

Various methods and apparatus for providing deep brain stimulation for the treatment of diseases such as Parkinson's Disease that do not require an onboard power supply that is implanted in the patient's body. Power may be supplied from outside of the body by, for example, near-field inductive coupling with an external power supply provided in, for example, a headgear worn by the patient. Power may also be supplied by providing an antenna for harvesting ambient energy, such as ambient RF energy, and converting it into DC power. In addition, the methods and apparatus provide for remote, wireless programming of the parameters that specify the nature of electrical pulses provided to the brain via probes implanted in the brain.

The invention provides a sleep detection-based integrated closed loop deep brain stimulator. The sleep detection-based integrated closed loop deep brain stimulator has a real-time sleep detection function, is capable of identifying the sleep or awake state of a patient and is capable of automatically adjustably outputting parameters of electrical stimulation in real time according to different states of the patient. When the patient is sleeping, a pulse generator automatically stops outputting the electrical stimulation or weakening the strength of the electrical stimulation output, and when the patient is awake, a normal operation mode of the pulse generator is recovered. On one hand, the system power consumption of the deep brain stimulator is favorably reduced, and thereby, the service life of the deep brain stimulator is prolonged, and on the other hand, the sleep detection-based integrated closed loop deep brain stimulator is favorable for reducing the harmful effects of the continuous high-frequency electrical simulation to the patient.

Due to the lack of internal anatomic detail with traditional magnetic resonance imaging, preoperative stereotactic planning for the treatment of tremor usually relies on indirect targeting based on atlas-derived coordinates. To overcome such disadvantages, a method is provided that allows for deep brain stimulation targeting based on brain connectivity. For example, probabilistic tractography-based thalamic segmentation for deep brain stimulator (DBS) targeting is suitable for the treatment of tremor.

A site-specific deep brain stimulation for enhancement of memory is described. A method of the site-specific deep brain stimulation for enhancement of memory may include implanting intracranial depth electrodes in a patient, wherein the electrodes are placed in right and / or left entorhinal regions, and stimulating the electrodes with current set below an after-discharge threshold. The method may include stimulation at a specific brain site in the medial temporal lobe, stimulation (ODTS) at specific stages of information processing. A system for site specific deep brain stimulation of entorhinal regions during specific stages of information processing is also described.

The invention discloses a deep brain stimulation system which comprises an external detection control and ultrasonic sending device and an intracerebral ultrasonic receiving and stimulation treatment device. The external detection control and ultrasonic sending device is positioned outside the body of a patient and mainly comprises a microprocessor, a storage unit, a detection unit, an electrode array, an ultrasonic signal amplifier, a transducer, a display unit, a keyboard unit, a power source unit and a clock unit, and an intracerebral ultrasonic receiving and stimulation treatment device is implanted deeply in brain tissue of the patient and mainly comprises a transducer, a voltage gain and rectifier circuit, a voltage stabilizer, a control circuit unit and a stimulation electrode. The deep brain stimulation system is used for treatment of nervous system diseases like Parkinson's disease, torsion spasm, spasmodic torticollis, chorea and epilepsy.

An external stimulator for the deep brain is composed of the internal induction coil and stimulating electrode, which are transplanted in human body, and the external controller for setting up the amplitude, frequency and width of stimulating pulses and composed of microprocessor, keyboard, display, interrupted oscillator, and the electric energy converter resisting of rectifying-filter circuit, resonance loop and external induction coil.

A system, method, and apparatus for a visualization system for deep brain stimulation. The visualization system comprises a camera system, a display system, and an information analyzer. The information analyzer is configured to display a group of electrodes for the deep brain stimulation on a head of a patient on the display system such that a visualization of the group of electrodes is displayed overlaid on the head of the patient in real time in a position corresponding to an actual position of the group of electrodes in a brain in the head of the patient. An operation of the group of electrodes sending an electrical signal into the head of the patient is displayed in the visualization, enabling visualizing a physical reaction of the patient to the deep brain stimulation in conjunction with the visualization of the operation of the group of electrodes.

The invention provides automatic control of a deep brain stimulation system (2) using tremor detection based on accelerometer signals. Because no manual interventions are necessary, the ease of use for the patient (1) is greatly enhanced. Furthermore the autonomy of the patients in normal daily life is increased. The present invention also results in a reduced energy consumption and consequently longer battery life. On the other side with the present invention an optimal treatment is possible, adjusted to the patient's symptoms without the help of a physician.

The invention belongs to a remote regulation and control method for an implanted medical device, and particularly relates to a method for remote regulation control as well as tracking survey of patient state of an implanted deep brain stimulator. The system is based on the SIP (session initiation protocol) and RTP (real-time transport protocol) as well as Bluetooth communication mode of the 3G (3rd generation) communication network, and realizes one-to-one visual safe remote regulation and control. The system mainly comprises a control end 1, a 3G mobile communication network 2, a client 3, aprogram controller 4 and an implanted pulse generator 5. The regulation and control method comprises the following steps: a doctor looks for relevant information of a patient through a computer 6 of the control end 1 and a 3G mobile phone 8, observes the physical sign of the patient, selects proper adjustment parameters and sends the adjustment parameters to the client 3 through the 3G mobile communication network 2; the client 3 communicates with the program controller 10 through a Bluetooth protocol; and the program controller 10 controls the pulse generator 11 and reversely returns the feedback information to the control end. According to the invention, the physical sign information of the patient can be acquired anytime and anywhere, the stimulation pulse parameters are adjusted, and the clinical requirements on tracking visit and quick diagnosis of the patient with the implanted deep brain stimulator are met; and moreover, as the public wireless communication network and common communication equipment are used, the cost is low, the reliability is high, and the practicability is strong.

The invention provides a brain deep stimulation device combining high-frequency electromagnetic waves and electric pulses. The device comprises a cylindrical metal inner core, an annular dielectric layer coating the cylindrical metal inner core and a metal tube located outside the dielectric layer. A metal lead is led from a side surface of the cylindrical metal inner core, the metal lead is connected to an external power supply, and the cylindrical metal inner core is used for conducting electric pulse stimulation. One end of the cylindrical metal inner core close to an action target is a signal output end, and the signal output end is a first tapered conical structure and is used for inserting a tested object, the other end of the cylindrical metal inner core is a signal input end connected to an input fiber and is used for receiving the high-frequency electromagnetic waves inputted into the cylindrical metal inner core by the input fiber. A coaxial waveguide structure is formed between the cylindrical metal inner core and the metal tube and transmits the high-frequency electromagnetic waves through the dielectric layer. The invention introduces a high-frequency electromagnetic field into the deep part of a brain to apply stimulation, the high-frequency electromagnetic waves and the electric pulses are combined to stimulate the deep part of the brain, and the deep brain stimulation effect is improved.

The invention aims to reduce puncture friction force between the cylindrical surface of a bushing electrode and brain tissue in a deep brain stimulation operation and lower the degree of puncture injury of the bushing electrode to brain tissue, and provides a bushing electrode with linear staggered array bionic micro-textures and for deep brain stimulation based on the idea of friction reduction of bionic micro-textures on a friction surface. According to the invention, a series of linear array groove bionic micro-textures are machined on the cylindrical surface of the bushing electrode; the linear array grooves are equidistantly distributed in 24 columns in the circumferential direction of the cylindrical surface of the bushing electrode; the total length of a bionic micro-texture area is59.5 mm, the heads of the linear grooves at the two ends of the bionic micro-texture area are aligned, the distance between the bionic micro-texture area and a puncture end face is 0.5 mm, and adjacent columns of the linear grooves are distributed in a staggered mode and can assist each other in supporting the wrapping effect of brain tissue on the cylindrical surface; and the widths of all the linear grooves are 18 microns, and the depths of all the linear grooves are 10 microns. Thus, the puncture friction force between the cylindrical surface of the bushing electrode and the brain tissue can be reduced, and the degree of puncture injury of the bushing electrode to the brain tissue is reduced.

An external deep stimulator for brain and its aligning unit are disclosed. The stimulator has external exciting coil and the induction output coil in human body for the coupling between internal and external signals. The aligning unit has the external permanent magnet close to said exciting coil and two magnetic cores respectively arranged in said exciting coil and induction output coil.

The present invention involves methods of stimulating tissue using one or more series of electrodes to apply energy through a combination of electrodes to stimulate various regions within an area of interest. Such an approach can triangulate areas where stimulation and / or treatment is needed for deep brain stimulation (DBS). In addition, the triangulation system and methods described herein can be applied to any portion of a body where stimulation of a particular area is required while using the vascular network to access tissue surrounding that particular area so that a combination of electrodes can be used to identify the region of interest that requires stimulation.

The invention provides a device and method for stimulating habenula nucleus and / or striae medullares and / or fasciculus retroflexus in a brain to treat mental diseases. The method includes the following steps: at least one electrode is placed in the habenula nucleus located at least one side, and / or in any part of the striae medullares and / or the fasciculus retroflexus, at least one contact point of the electrode is in the area, the electrode is connected to at least one conductor, a terminal conductor is connected to a pulse generator, the electrode can transmit a stimulation signal parallel to an axon to the area, the pulse generator sends the stimulation signal to any contact points of the electrode through the conductor, and the electrode part in the area regulates the nerve activity. The device and method realize the stimulation of the habenula nucleus and / or upstream and downstream fiber bundles by using at least one electrode, and realize the feasibility of using a deep brain stimulation system to treat the mental diseases such as depression and addiction behaviors.

The present invention relates to deep brain stimulator and belongs to the field of medical equipment. The class D amplifier driven external deep brain stimulator includes one in vivo signal stimulating part, one in vitro signal generating and controlling part, and one signal coupling module for signal coupling between the two foregoing parts. The in vivo signal stimulating part includes one pair of stimulating electrodes; and the in vitro signal generating and controlling part includes one class D amplifier and pulse driver module, one micro controller module. The pulse signal the micro controller module generates is amplified in the class D amplifier and pulse driver module and introduced with the signal coupling module to body to excite the stimulating electrode pair. The present invention has the advantages of low power consumption and high efficiency. The in vivo inducing output coil and stimulating electrodes are implanted via once operation and need no power source.

The disclosed induced charge-type brain deep-part stimulator comprises: the in-vivo part with the in-vivo part of a dual-pole switch, an alkaline Zn-Mn dioxide cell, a monitor system for voltage and temperature of the cell, and a stimulating electrode; and the in-vitro part with a MPU, a pulse adjustment circuit, a charge-manage circuit, a in-vitro monitor system for voltage and temperature, and the in-vitro part of a dual-pole switch. This invention has strong resistance to interference, and has wide application, such as Parkinsonism, obsession and epilepsy.

The invention provides a fully implanted closed-loop brain deep simulating system based on brain deep electric signal sleep detection. The system utilizes a brain deep electric stimulator electrode for sensing an electrocardiosignal and a brain deep electric signal at a stimulating target point. The system extracts time domain, frequency domain and complexity analysis characteristics and further realizes detection and judgment on a sleep state by means of a classification algorithm, thereby adjusting the switching state and the output parameter of the stimulator and realizing closed-loop nerve stimulation in the sleep state. The implanted closed-loop brain deep simulating system provided by the invention has advantages of reducing side effects of brain deep electric stimulation and saving electric energy of a battery.

The invention discloses a percutaneous closed-loop control charging device for implantation type medical treatment instrument and belongs to the technical field of implantation medical instrument. The percutaneous closed-loop control charging device for implantation type medical treatment instrument comprises an external charger and an internal implantation type medical instrument. An external energy transmitting coil is a large-size flat magnetic core coil, and an internal energy receiving coil is a hollow coil; the external energy transmitting coil transmits electromagnetic energy by adopting a resonance electromagnetic coupling manner with parallel central shafts; and the electrical energy obtained by the internal energy receiving coil charges an internal rechargeable battery through an internal charge control circuit. The closed-loop control charging device communicates in a pulse position modulation manner for closed-loop control to ensure the energy received by the implantation medical instrument in different charging phases to be within the normal range, effectively control the heating and increase the safety; the closed-loop control charging device calculates the efficiency by the internal feedback parameter to realize counterpoint prompt and increase the charging efficiency. The percutaneous wireless charging method can charge the implantation type medical instrument by a titanium casing, is safe and reliable in charging, and can be applied to all types of implantation type medical instruments equivalent to a deep brain stimulator in power level.

The invention relates to an electrode fixing device, belonging to the technical field of medical instruments for deep brain stimulation. The invention aims to solve the problems that an electrode fixing device in the prior art is inaccurate in electrode positioning, poor in stability, tedious in assembly procedure, unbalanced in clamping position and easy to loosen. The electrode fixing device comprises a base and a rotary clamping assembly, wherein the rotary clamping assembly comprises a locking ring and a plurality of locking pieces; the locking ring and the multiple locking pieces are arranged on the base; and the multiple locking pieces stretch out or retract in space defined by the base and the locking ring. The electrode fixing device is small in size and convenient to operate, and a locking device does not need to be assembled on site when used in an operation, so assembling procedures of operators are reduced, the situation that an electrode is accidentally pulled when the part is assembled on site is reduced, and electrode positioning accuracy and stability can be improved.

The invention discloses an impedance measuring device and method on the basis of deep brain stimulator electrodes. The device comprises a pulse emitting circuit, a signal amplifying circuit, an analog-to-digital conversion circuit, a processing controller, an electrode terminal selection module and the deep brain stimulator electrodes, wherein an output end of the processing controller is connected to a control end of the pulse emitting circuit and a control end of the electrode terminal selection module, an output end of the pulse emitting circuit is connected to the deep brain stimulator electrodes through the electrode terminal selection module, an input end of the signal amplifying circuit is connected to the deep brain stimulator electrodes through the electrode terminal selection module, and an output end of the signal amplifying circuit is connected to the processing controller through the analog-to-digital conversion circuit. The device and method can measure a contact impedance value between the deep brain stimulator electrodes and brain tissue and an impedance value among different pieces of the brain tissue.