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Preparation method and application of bionic composite nanofiber stent material

A technology of scaffold materials and composite fibers, which is applied in the field of preparation of bionic composite nanofiber scaffold materials, can solve the problem that bionic bone scaffolds cannot meet good mechanical properties and biocompatibility at the same time, and achieve excellent hydrophilicity and good biophase The effect of capacitive, good flexibility

Inactive Publication Date: 2020-03-17
DONGHUA UNIV
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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a preparation method and application of a biomimetic composite nanofiber scaffold material, which overcomes the defect that the prior art biomimetic bone scaffold cannot simultaneously satisfy good mechanical properties and biocompatibility

Method used

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  • Preparation method and application of bionic composite nanofiber stent material
  • Preparation method and application of bionic composite nanofiber stent material
  • Preparation method and application of bionic composite nanofiber stent material

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Embodiment 1

[0045] 1. Preparation of PLLA / SF biomimetic composite nanofiber scaffold loaded with osteoblast extracellular matrix, the specific method is as follows:

[0046] a. Extraction of silk fibroin: after removing impurities from silkworm cocoons (Hebei Baoding Chinese herbal medicine retail and wholesale), place them in a mass of Na 2 CO 3 (Shanghai Lingfeng Chemical Reagent Co., Ltd.) in an aqueous solution, boil for 30-50 minutes for degumming, and then clean it with deionized water; repeat the above steps until the color of the aqueous solution after boiling has no obvious change, and the silk is pure white. At this time, sericin Remove it clean; wring out the moisture of the degummed silk, spread it loosely on the aluminum foil, degummed at 50°C, and then weigh it after drying; dissolve the dried silk in the ternary system CaCl with a bath ratio of 1:10 2 / CH 3 CH 2 OH / H 2 Dissolve in O (molar ratio 1:2:8) (Shanghai Lingfeng Chemical Reagent Co., Ltd.) solution, heat and st...

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Abstract

The invention relates to a preparation method and application of a bionic composite nanofiber stent material. The material comprises an artificial nanofiber scaffold material and an extracellular matrix material derived from cells. According to the composite nanofiber material disclosed by the invention, advantages of no toxicity, degradability and the like of the traditional L-polylactic acid biomedical material are reserved and mechanical properties such as the flexibility and the tensile strength of the stent material are also improved; since the extracellular matrix has high conservative property among different species, decellularized extracellular matrix stent has advantages of low immunogenicity, excellent biocompatibility and the like; and the mesenchymal stem cells that are goingto be implanted into the body of a patient and are amplified can be inoculated and thus a tissue engineering prosthesis stent for being implanted into the human body to replace defective tissues is formed after proper culturing.

Description

technical field [0001] The invention belongs to the field of tissue engineering materials and their preparation and application, in particular to a preparation method and application of a bionic composite nanofiber scaffold material. Background technique [0002] Bone injury is a clinical case that has increased sharply in recent years, but the body's self-repair function is limited. Generally, for defects with a diameter of more than 2mm, its healing ability is greatly reduced. Therefore, when tissue engineering was born, it also brought the hope of completely healing bone damage. In 1987, the National Science Foundation of the United States first recognized tissue engineering technology, and its three elements include seed cells, scaffolds and bioactive factors. Among them, the key is to prepare a scaffold that can simulate the microenvironment in vivo. An ideal scaffold not only provides a place for seed cells to attach, but also can better promote the proliferation and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/26A61L27/58
CPCA61L27/26A61L27/3633A61L27/3687A61L27/58A61L2400/12C08L89/00C08L67/04
Inventor 娄向新刘红梅吴云亮李月霞周磊宋滇文张传忠
Owner DONGHUA UNIV
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