Traditional Chinese medicine privacy nursing plaster and preparation method thereof

A nursing sticker, private technology, applied in pharmaceutical formulations, pharmaceutical science, drug combination and other directions, can solve the problems of poor antibacterial and bactericidal effect, poor air permeability and waterproofness, etc., to improve the curative effect, strong adhesion, excellent air permeability and water absorption Effect

Inactive Publication Date: 2020-03-27

刘敏

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AI-Extracted Technical Summary

Problems solved by technology

The nursing traditional Chinese medicine patch in the above-mentioned patent has the following de...

Method used

At last, the toughening modification auxiliary agent is with coconut fiber, zinc oxide, nano-titanium dioxide, polylactic acid, attapulgite, sodium hexametaphosphate, 2,3-epoxypropyl trimethyl ammonium chloride, isopropyl Alcohol, polypyrrole, N-methylol acrylamide, castor silk, 4-methoxyphenol, ammonium chloride, silane coupling agent KH-550 are used as raw materials, by utilizing the porous adsorption properties of polylactic acid and attapulgite , as the basis for the adhesion of coconut fiber, zinc oxide, and nano-titanium dioxide, and because polylactic acid, attapulgite, coconut fiber, zinc oxide, and nano-titanium dioxide all contain a large number of hydroxyl groups, the surface of the silane coupling agent KH-550 Under the effect of branch modification, the combination of unsaturated bonds on the surface of N-methylolacrylamide and 4-methoxyphenol is realized, and the high toughness of coconut fiber, zinc and titanium elements in zinc oxide and nano-titanium dioxide can inhibit bacterial surface respiration The action of the enzyme thus realizes the bactericidal effect, and the added castor silk is combined with the coconut fiber to further strengthen the toughness, and the high polymer containing the π-electron conjugated system of polypyrrole is used, and its conductive principle is The conjugated structural chain provides a channel for charge flow, and after adding dopants, under the impetus of external doping, the polymer with a certain structure will break through the insulating region, so that the internal electrons are released to form freely moving charges, so the fabric The surface can conduct electricity, thereby effectively improving the anti-radiation performance.

Furthermore, modified antibacterial auxiliary agent is N-(4-hydroxyl-3-methoxy-benzyl) acrylamide, diammonium hydrogen phosphate, ethyl acrylate, azobisisobutyronitrile, polyethylene glycol Alcohol, silane coupling agent KH-570, dibutyltin dilaurate, chitosan, sodium bisulfite, N-(4-hydroxy-3-methoxy-benzyl) propylene with capsaicin-derived structure Amide, as an alkaloid, can effectively avoid harmful bacteria, and as the base material of the modified antibacterial additive, N,N-dimethylacetamide is used as an aprotic highly polar solvent, and ethyl acrylate is used as a monomer , with the silane coupling agent KH-570 as the gr...

Abstract

The application discloses a traditional Chinese medicine privacy nursing plaster. The traditional Chinese medicine privacy nursing plaster comprises an ointment glue layer, an ointment stuffing layerand a second gauze layer. The traditional Chinese medicine privacy nursing plaster is characterized in that a first gauze layer, a polylactic acid antibacterial supporting layer and an adhering layerare arranged between the ointment glue layer and the second gauze layer; the first gauze layer is adhered between the ointment glue layer and the polylactic acid antibacterial supporting layer; the polylactic acid antibacterial supporting layer is adhered between the first gauze layer and the adhering layer; the adhering layer is adhered between the second gauze layer and the polylactic acid antibacterial supporting layer; a plurality of skeletons with a ladder-shaped structure are arranged in the polylactic acid antibacterial supporting layer; the ointment stuffing layer is stuffed in the skeletons; a ventilating net is adhered between the ointment filling layer and the first gauze layer; the polylactic acid antibacterial supporting layer adopts a cellular structure; and a plurality of ventilating holes which communicate with the polylactic acid antibacterial supporting layer are formed in the adhering layer. The invention also provides the preparation method of the traditional Chinese medicine privacy nursing plaster. The prepared traditional Chinese medicine privacy nursing plaster disclosed by the invention has excellent antibacterial performance and gas permeability, can achieve the effect of performing sterilizing and antibacterial treatment on privacy locations, is good in water absorption and can restrain the growth of the bacteria.

Application Domain

Organic active ingredientsPeptide/protein ingredients +5

Technology Topic

Anti bacterialPolylactic acid +3

Image

Examples

Experimental program(3)
Comparison scheme(1)
Effect test(1)

Example Embodiment

[0032] Example 1:

[0033] Reference Figure 1-2 , The private care patch of traditional Chinese medicine proposed in the embodiment of the present invention includes a plaster glue layer 1, an ointment filling layer 5 and a second gauze layer 9. A first gauze layer 2, polylactic acid is arranged between the ointment glue layer and the second gauze layer 9 The antibacterial support layer 3 and the adhesive layer 7, the first gauze layer 2 is bonded between the ointment glue layer and the polylactic acid antibacterial support layer 3, and the polylactic acid antibacterial support layer 3 is adhered to the first gauze layer 2 and the adhesive layer 7 In between, the adhesive layer 7 is bonded between the second gauze layer 9 and the polylactic acid antibacterial support layer 3. The polylactic acid antibacterial support layer 3 is provided with a plurality of trapezoidal frameworks 4, and the ointment filling layer 5 is filled in the framework 4 Inside, a breathable mesh 6 is bonded between the ointment filling layer 5 and the first gauze layer 2, the polylactic acid antibacterial support layer 3 has a honeycomb structure, and the adhesive layer 7 is provided with a plurality of connections connected to the polylactic acid antibacterial support layer 3. Vent 8.

[0034] In this embodiment, the thickness of the first gauze layer 2 is m1, and the thickness of the second gauze layer 9 is m2, m2

[0035] The raw materials of the breathable net include: 40 parts by weight of hemp fiber, 6.5 parts of hydrogel, 6 parts of attapulgite, 6.5 parts of sodium alginate, 6 parts of acrylamide, 3.5 parts of potassium persulfate, and N,N`-methylene 2.5 parts of base bisacrylamide, 4.5 parts of carbon nanotubes, 5 parts of chitosan, 7.5 parts of antibacterial reinforcement aids, 6 parts of water absorption reinforcement aids, and 2 parts of silane coupling agent KH-570.

[0036] The antibacterial enhancement aid is prepared according to the following process: 6 parts by weight of 3,4-dihydroxybenzaldehyde, 4 parts of sodium hexametaphosphate, 3 parts of diphenylmethane diisocyanate, 4 parts of dibutyl tin dilaurate , 2.5 parts of acetic acid and 4 parts of methanol are mixed uniformly, stand for 4 hours at room temperature, then add 3.5 parts of attapulgite and 4 parts of sodium borohydride to mix evenly, stir at 750r/min for 30 minutes, and the precipitate obtained after suction filtration is dialyzed for 6.5 hours , After freeze-drying, material a is obtained; 6 parts of silane coupling agent KH-560, 6 parts of polyethylene glycol and 4 parts of sodium bisulfite are mixed uniformly, and then material a is added and mixed uniformly. The temperature is raised to 120°C, and the temperature is kept for 30 minutes. Then stir at 300r/min for 30min, and cool to room temperature to obtain the antibacterial enhancement aid.

[0037] The water absorption strengthening aid is prepared according to the following process: 85 parts by weight of bentonite, 10 parts of kaolin, 6.5 parts of chitooligosaccharides, 4 parts of sodium carbonate, 4.5 parts of dechitin and 6 parts of fly ash are mixed uniformly, Stir at 550r/min for 25min, then dry in -40℃ freeze dryer for 30min, then add 6 parts of polyethylene glycol and 5.5 parts of glycolic acid and mix well, stir at 5000r/min for 15min, then add 4.5 parts of arabinoxy Sugar and 5.5 parts of hyaluronic acid were mixed uniformly, heated to 75°C for 15 minutes, and then centrifuged at 11500r/min to collect the precipitate, washed with water and freeze-dried to obtain a water-absorbing and reinforcing auxiliary.

[0038] The raw materials of the polylactic acid antibacterial support layer in parts by weight include: 100 parts of polylactic acid, 50 parts of bisphenol A polysulfone resin, 6.5 parts of polycarbonate, 5 parts of bamboo charcoal fiber, 5 parts of carbon nanotubes, and silane coupling agent 2 parts of KH-560, 20 parts of modified antibacterial additives, 22 parts of toughening modified additives.

[0039] The modified antibacterial additive is prepared according to the following process: 6 parts by weight of N-(4-hydroxy-3-methoxy-benzyl)acrylamide and 5.5 parts of N,N-dimethylacetamide are mixed uniformly, Stir at 750r/min for 30min, then heat to 80℃, keep for 2h, and then add nitrogen, add 6.5 parts of calcium nitrate tetrahydrate, 6 parts of diammonium hydrogen phosphate, 3.5 parts of ethyl acrylate and 3 parts of azobisisobutyl Mix the nitrile uniformly, stir at 500r/min for 12h, and cool to room temperature to obtain material b; under the protection of nitrogen, heat up 4.5 parts of polyethylene glycol to 105°C for dehydration for 2h, then lower the temperature to 55°C, add material b, 5.5 parts Silane coupling agent KH-570 and 4 parts of dibutyltin dilaurate were mixed uniformly, heated to 90℃, kept for 3.5h, then heated to 95℃, kept for 15min, added 12 parts of chitosan and mixed well, then cooled to 20℃ , Add 4.5 parts of sodium bisulfite and mix well, stir at 750r/min for 3h, and cool to room temperature to obtain the modified antibacterial auxiliary.

[0040] The toughening modifier is prepared according to the following process: 5 parts by weight of coconut fiber, 6 parts of zinc oxide and 3 parts of nano titanium dioxide are mixed uniformly, after grinding, pass through a 30-mesh sieve, and then add 6.5 parts of polylactic acid and mix uniformly. Mix 3.5 parts of attapulgite and 4.5 parts of sodium hexametaphosphate in an internal mixer at 175℃, 60r/min rotation speed for 30min, cooling is at room temperature, mix evenly, then adjust the pH to 7, and then stir for 30min at 750r/min rotation speed. Then heat up to 35℃, keep for 20min, cool to room temperature, then add 5.5 parts of 2,3-epoxypropyltrimethylammonium chloride and 6 parts of isopropanol and mix evenly, heat up to 80℃, keep for 12h, and cool to At room temperature, after washing, filter by suction, add 6 parts of polypyrrole, 6 parts of N-methylolacrylamide, 5 parts of castor silk, 6.5 parts of 4-methoxyphenol and 3 parts of ammonium chloride and mix well, and heat up to 140℃ , Keep for 25min, cool to room temperature, then add 6 parts of silane coupling agent KH-550 and mix well, soak at 60℃ for 60min, then pre-bake at 80℃ for 10min, then bake at 160℃ for 3min, clean and dry to constant weight, Cool to room temperature to obtain toughening modifier.

[0041] The raw materials of the ointment filling layer include 10 parts by weight of Pinus sylvestris, 5 parts of cholic acid, 6 parts of polyasparagine, 4 parts of Andrographis paniculata, 3 parts of iron tree root, 6 parts of Forsythia, 5.5 parts of Anemarrhena, 5.5 parts of Polygonum cuspidatum, 5 parts of silk fibroin.

[0042] The present invention also provides a method for preparing the private nursing patch of traditional Chinese medicine, which includes the following steps:

[0043] S1. Mix pine wormwood, cholic acid, polyasparagine, andrographis paniculata, iron tree root, forsythia, Anemarrhena, Polygonum cuspidatum, silk fibroin and water evenly, heat up to 90℃, keep for 30min, and then continue heating to obtain moisture content 5% of material I;

[0044] S2. Put polylactic acid, bisphenol A polysulfone resin, polycarbonate, bamboo charcoal fiber, carbon nanotubes, silane coupling agent KH-560, modified antibacterial additives and toughening modifiers into the mixer In the middle, the temperature is raised to 200°C and the temperature is kept for 20 minutes to obtain the material II, the skeleton is embedded in the polylactic acid antibacterial support layer molding mold, and then the material II is introduced into the mold to form a honeycomb-shaped polylactic acid antibacterial support layer with a skeleton;

[0045] S3. Fill material I into the honeycomb-shaped holes in the polylactic acid antibacterial support layer, and cool to room temperature to obtain a polylactic acid antibacterial support layer filled with ointment filling layer;

[0046] S4. Adhere the breathable net, the adhesive layer, the first gauze and the second gauze on both sides of the polylactic acid antibacterial support layer, and then adhere the plaster glue layer on one side of the first gauze to obtain a private Chinese medicine care patch.

Example Embodiment

[0047] Example 2

[0048] Reference Figure 1-2 , The private care patch of traditional Chinese medicine proposed in the embodiment of the present invention includes a plaster glue layer 1, an ointment filling layer 5 and a second gauze layer 9. A first gauze layer 2, polylactic acid is arranged between the ointment glue layer and the second gauze layer 9 The antibacterial support layer 3 and the adhesive layer 7, the first gauze layer 2 is bonded between the ointment glue layer and the polylactic acid antibacterial support layer 3, and the polylactic acid antibacterial support layer 3 is adhered to the first gauze layer 2 and the adhesive layer 7 In between, the adhesive layer 7 is bonded between the second gauze layer 9 and the polylactic acid antibacterial support layer 3. The polylactic acid antibacterial support layer 3 is provided with a plurality of trapezoidal frameworks 4, and the ointment filling layer 5 is filled in the framework 4 Inside, a breathable mesh 6 is bonded between the ointment filling layer 5 and the first gauze layer 2, the polylactic acid antibacterial support layer 3 has a honeycomb structure, and the adhesive layer 7 is provided with a plurality of connections connected to the polylactic acid antibacterial support layer 3. Vent 8.

[0049] In this embodiment, the thickness of the first gauze layer 2 is m1, and the thickness of the second gauze layer 9 is m2, m2

[0050] The raw materials of the breathable net include: 30 parts of hemp fiber, 9 parts of hydrogel, 4 parts of attapulgite, 9 parts of sodium alginate, 4 parts of acrylamide, 5 parts of potassium persulfate, N,N`-methylene 1 part of base bisacrylamide, 6 parts of carbon nanotubes, 2 parts of chitosan, 10 parts of antibacterial reinforcement additives, 8 parts of water absorption reinforcement additives, and 3 parts of silane coupling agent KH-570.

[0051] The antibacterial enhancement aid is prepared according to the following process: 4 parts by weight of 3,4-dihydroxybenzaldehyde, 6 parts of sodium hexametaphosphate, 1 part of diphenylmethane diisocyanate, and 6 parts of dibutyltin dilaurate , 1 part of acetic acid and 5 parts of methanol are mixed uniformly, stand at room temperature for 3h, then add 5 parts of attapulgite and 3 parts of sodium borohydride to mix evenly, stir at 850r/min for 20min, and dialyze the precipitate obtained after suction filtration for 8h, After freeze-drying, material a is obtained; 4 parts of silane coupling agent KH-560, 9 parts of polyethylene glycol and 2 parts of sodium bisulfite are mixed uniformly, and then material a is added and mixed uniformly. The temperature is increased to 130°C, and the temperature is kept for 20 minutes. Stir at 350r/min for 20min, and cool to room temperature to obtain the antibacterial enhancing additive.

[0052] The water absorption strengthening aid is prepared according to the following process: 80 parts by weight of bentonite, 15 parts of kaolin, 4 parts of chitooligosaccharides, 6 parts of sodium carbonate, 1 part of dechitin and 9 parts of fly ash are mixed uniformly, Stir at 350r/min for 30min, then dry in a freeze dryer at -30℃ for 40min, then add 4 parts of polyethylene glycol and 7 parts of glycolic acid to mix evenly, stir at 4500r/min for 20min, then add 3 parts of arabinoxy Sugar and 7 parts of hyaluronic acid were mixed uniformly, heated to 70°C for 20 minutes, and then centrifuged at 8500r/min to collect the precipitate, washed with water and freeze-dried to obtain a water-absorbing and reinforcing auxiliary.

[0053] The raw materials of the polylactic acid antibacterial support layer in parts by weight include: 80 parts of polylactic acid, 60 parts of bisphenol A polysulfone resin, 4 parts of polycarbonate, 6 parts of bamboo charcoal fiber, 2 parts of carbon nanotubes, and silane coupling agent 3 parts of KH-560, 15 parts of modified antibacterial additives, 32 parts of toughening modified additives.

[0054] The modified antibacterial additive is prepared according to the following process: 4 parts by weight of N-(4-hydroxy-3-methoxy-benzyl)acrylamide and 7 parts of N,N-dimethylacetamide are mixed uniformly, Stir at 650r/min for 40 minutes, then heat to 75°C, keep for 3 hours, then pass in nitrogen, add 4 parts of calcium nitrate tetrahydrate, 9 parts of diammonium hydrogen phosphate, 2 parts of ethyl acrylate and 5 parts of azobisisobutyl Mix the nitrile uniformly, stir at 450r/min for 14h, and cool to room temperature to obtain material b; under the protection of nitrogen, heat 3 parts of polyethylene glycol to 110°C for dehydration for 1h, then lower the temperature to 60°C, add material b, 4 parts Silane coupling agent KH-570 and 6 parts of dibutyltin dilaurate were mixed uniformly, heated to 65℃, kept for 5h, then heated to 90℃, kept for 20min, added 9 parts of chitosan and mixed well, then cooled to 25℃, Add 3 parts of sodium bisulfite and mix well, stir at 850r/min for 2h, and cool to room temperature to obtain modified antibacterial additives.

[0055] The toughening modifier is prepared according to the following process: 2 parts by weight of coconut fiber, 9 parts of zinc oxide and 1 part of nanometer titanium dioxide are mixed uniformly, after grinding, pass through a 40-mesh sieve, and then add 4 parts of polylactic acid and mix uniformly. Mix 2 parts of attapulgite and 6 parts of sodium hexametaphosphate in an internal mixer at 190°C at a speed of 50r/min for 40 minutes. Cooling is at room temperature. Mix 2 parts of attapulgite and 6 parts of sodium hexametaphosphate evenly, then adjust the pH to 7, and then stir at 650r/min for 40 minutes. Then heat up to 30℃, keep for 30min, cool to room temperature, then add 4 parts of 2,3-epoxypropyltrimethylammonium chloride and 9 parts of isopropanol and mix evenly, heat up to 70℃, keep for 14h, and cool to At room temperature, after washing, filter by suction, add 4 parts of polypyrrole, 9 parts of N-methylolacrylamide, 2 parts of castor silk, 9 parts of 4-methoxyphenol and 1 part of ammonium chloride and mix well, and heat to 150℃ , Keep for 15min, cool to room temperature, then add 9 parts of silane coupling agent KH-550 and mix well, immerse at 55℃ for 70min, then pre-bake at 75℃ for 15min, then bake at 150℃ for 4min, clean and dry to constant weight, Cool to room temperature to obtain toughening modifier.

[0056] The raw materials of the ointment filling layer by weight include: 5 parts of Pinus sylvestris, 6 parts of cholic acid, 3 parts of polyasparagine, 6 parts of Andrographis paniculata, 1 part of iron tree root, 8 parts of Forsythia, 3 parts of Anemarrhena, 7 parts of Polygonum cuspidatum, 2 parts of silk fibroin.

[0057] The present invention also provides a method for preparing the private nursing patch of traditional Chinese medicine, which includes the following steps:

[0058] S1. Mix pine wormwood, cholic acid, polyasparagine, andrographis paniculata, iron tree root, forsythia, Anemarrhena, Polygonum cuspidatum, silk fibroin and water evenly, heat up to 80℃, keep for 40min, and then continue heating to obtain moisture content 4% of material I;

[0059] S2 Put polylactic acid, bisphenol A polysulfone resin, polycarbonate, bamboo charcoal fiber, carbon nanotubes, silane coupling agent KH-560, modified antibacterial additives and toughening modifiers into the mixer In the middle, the temperature is raised to 250°C and the temperature is kept for 10 minutes to obtain material II, the skeleton is embedded in the polylactic acid antibacterial support layer molding mold, and then the material II is introduced into the mold to form a honeycomb polylactic acid antibacterial support layer with a skeleton;

[0060] S3. Fill material I into the honeycomb-shaped holes in the polylactic acid antibacterial support layer, and cool to room temperature to obtain a polylactic acid antibacterial support layer filled with ointment filling layer;

[0061] S4. Adhere the breathable net, the adhesive layer, the first gauze and the second gauze on both sides of the polylactic acid antibacterial support layer, and then adhere the plaster glue layer on one side of the first gauze to obtain a private Chinese medicine care patch.

Example Embodiment

[0062] Example 3

[0063] Reference Figure 1-2 , The private care patch of traditional Chinese medicine proposed in the embodiment of the present invention includes a plaster glue layer 1, an ointment filling layer 5 and a second gauze layer 9. A first gauze layer 2, polylactic acid is arranged between the ointment glue layer and the second gauze layer 9 The antibacterial support layer 3 and the adhesive layer 7, the first gauze layer 2 is bonded between the ointment glue layer and the polylactic acid antibacterial support layer 3, and the polylactic acid antibacterial support layer 3 is adhered to the first gauze layer 2 and the adhesive layer 7 In between, the adhesive layer 7 is bonded between the second gauze layer 9 and the polylactic acid antibacterial support layer 3. The polylactic acid antibacterial support layer 3 is provided with a plurality of trapezoidal frameworks 4, and the ointment filling layer 5 is filled in the framework 4 Inside, a breathable mesh 6 is bonded between the ointment filling layer 5 and the first gauze layer 2, the polylactic acid antibacterial support layer 3 has a honeycomb structure, and the adhesive layer 7 is provided with a plurality of connections connected to the polylactic acid antibacterial support layer 3. Vent 8.

[0064] In this embodiment, the thickness of the first gauze layer 2 is m1, and the thickness of the second gauze layer 9 is m2, m2

[0065] The raw materials of the breathable mesh include: 50 parts by weight of hemp fiber, 4 parts of hydrogel, 8 parts of attapulgite, 4 parts of sodium alginate, 8 parts of acrylamide, 2 parts of potassium persulfate, N,N`-methylene 4 parts of base bisacrylamide, 3 parts of carbon nanotubes, 8 parts of chitosan, 5 parts of antibacterial reinforcement additives, 14 parts of water absorption reinforcement additives, 1 part of silane coupling agent KH-570.

[0066] The antibacterial enhancement aid is prepared according to the following process: 8 parts by weight of 3,4-dihydroxybenzaldehyde, 2 parts of sodium hexametaphosphate, 5 parts of diphenylmethane diisocyanate, and 2 parts of dibutyltin dilaurate , 4 parts of acetic acid and 3 parts of methanol are mixed uniformly, stand at room temperature for 5 hours, then add 2 parts of attapulgite and 5 parts of sodium borohydride to mix evenly, stir at 650r/min for 40 minutes, and dialyze the precipitate obtained after suction filtration for 5 hours. After freeze-drying, material a is obtained; 8 parts of silane coupling agent KH-560, 3 parts of polyethylene glycol and 6 parts of sodium bisulfite are mixed uniformly, and then material a is added and mixed uniformly. The temperature is increased to 110°C, and the temperature is kept for 40 minutes. Stir at 250r/min for 20min, and cool to room temperature to obtain the antibacterial enhancing additive.

[0067] The water absorption strengthening aid is prepared according to the following process: 90 parts by weight of bentonite, 5 parts of kaolin, 9 parts of chitooligosaccharides, 2 parts of sodium carbonate, 8 parts of dechitin and 3 parts of fly ash are mixed uniformly, Stir at 650r/min for 20 minutes, then dry in a freeze dryer at -50°C for 20 minutes, then add 8 parts of polyethylene glycol and 4 parts of glycolic acid to mix well, stir at 5500r/min for 10 minutes, and then add 6 parts of arabinoxy Sugar and 4 parts of hyaluronic acid were mixed uniformly, heated to 80°C for 10 minutes, and then centrifuged at 12000r/min to collect the precipitate, washed with water and freeze-dried to obtain a water-absorbing and reinforcing auxiliary.

[0068] The raw materials of the polylactic acid antibacterial support layer in parts by weight include: 120 parts of polylactic acid, 40 parts of bisphenol A polysulfone resin, 9 parts of polycarbonate, 4 parts of bamboo charcoal fibers, 8 parts of carbon nanotubes, and silane coupling agent 1 part of KH-560, 25 parts of modified antibacterial additives, 18 parts of toughening modified additives.

[0069] The modified antibacterial additives are prepared according to the following process: 8 parts by weight of N-(4-hydroxy-3-methoxy-benzyl)acrylamide and 4 parts of N,N-dimethylacetamide are mixed uniformly, Stir at 850r/min for 20min, then heat to 85℃, keep for 1h, then pass in nitrogen, add 9 parts of calcium nitrate tetrahydrate, 3 parts of diammonium hydrogen phosphate, 5 parts of ethyl acrylate and 1 part of azobisisobutyl Mix the nitrile uniformly, stir at 550r/min for 10h, and cool to room temperature to obtain material b; under the protection of nitrogen, heat 3 parts of polyethylene glycol to 110°C for dehydration for 1h, then lower the temperature to 60°C, add material b, 4 parts Silane coupling agent KH-570 and 6 parts of dibutyltin dilaurate were mixed uniformly, heated to 65℃, kept for 5h, then heated to 90℃, kept for 20min, added 9 parts of chitosan and mixed well, then cooled to 25℃, Add 3 parts of sodium bisulfite and mix well, stir at 850r/min for 2h, and cool to room temperature to obtain modified antibacterial additives.

[0070] The toughening modifier is prepared according to the following process: 8 parts by weight of coconut fiber, 3 parts of zinc oxide and 5 parts of nano-titanium dioxide are mixed uniformly, after grinding, pass a 20-mesh sieve, and then add 9 parts of polylactic acid and mix uniformly. Mix 5 parts of attapulgite and 3 parts of sodium hexametaphosphate in an internal mixer at 160℃, 70r/min speed for 20min, cooling is at room temperature, and then adjust pH to 7, and then stir at 850r/min for 20min, Then the temperature is increased to 40°C, kept for 10 minutes, cooled to room temperature, and then 7 parts of 2,3-epoxypropyltrimethylammonium chloride and 3 parts of isopropanol are added and mixed uniformly. The temperature is increased to 90°C, kept for 10 hours, and cooled to At room temperature, after washing, filter by suction, add 8 parts of polypyrrole, 3-9 parts of N-methylolacrylamide, 2 parts of castor silk, 9 parts of 4-methoxyphenol and 1 part of ammonium chloride and mix well, and heat to 150℃, keep for 15min, cool to room temperature, then add 9 parts of silane coupling agent KH-550 and mix well, immerse at 55℃ for 70min, then pre-bake at 75℃ for 15min, then bake at 150℃ for 2min, clean and dry to constant Heavy, cool to room temperature to obtain toughening modifier.

[0071] The raw materials of the ointment filling layer include 15 parts by weight of Pinus sylvestris, 4 parts of cholic acid, 9 parts of polyasparagine, 2 parts of Andrographis paniculata, 5 parts of iron tree root, 4 parts of Forsythia, 8 parts of Anemarrhena, 4 parts of Polygonum cuspidatum, 8 parts of silk fibroin.

[0072] The present invention also provides a method for preparing the private nursing patch of traditional Chinese medicine, which includes the following steps:

[0073] S1. Mix pine wormwood, cholic acid, polyasparagine, andrographis paniculata, iron tree root, forsythia, Anemarrhena, Polygonum cuspidatum, silk fibroin and water evenly, heat up to 100℃, keep for 20min, and then continue heating to obtain moisture content 6% of material I;

[0074] S2. Put polylactic acid, bisphenol A polysulfone resin, polycarbonate, bamboo charcoal fiber, carbon nanotubes, silane coupling agent KH-560, modified antibacterial additives and toughening modifiers into the mixer In the middle, the temperature is raised to 150°C and the temperature is kept for 30 minutes to obtain material II. The skeleton is embedded in the polylactic acid antibacterial support layer forming mold, and then the material II is introduced into the mold to form a honeycomb polylactic acid antibacterial support layer with a skeleton;

[0075] S3. Fill material I into the honeycomb-shaped holes in the polylactic acid antibacterial support layer, and cool to room temperature to obtain a polylactic acid antibacterial support layer filled with ointment filling layer;

[0076] S4. Adhere the breathable net, the adhesive layer, the first gauze and the second gauze on both sides of the polylactic acid antibacterial support layer, and then adhere the plaster glue layer on one side of the first gauze to obtain a private Chinese medicine care patch.

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Traditional Chinese medicine privacy nursing plaster and preparation method thereof

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