Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of multifunctional oxidation-resistant magnetic nanocomposite material and preparation method thereof

A nanocomposite material and magnetic nanotechnology, applied in the field of nanobiomedical materials, can solve the problems of difficult to achieve precise targeted delivery and low utilization rate, and achieve precise targeted delivery, good biocompatibility, and excellent anti-oxidation The effect of sex and magnetism

Active Publication Date: 2021-12-31
TONGJI UNIV
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, many nanozymes with inherent enzymatic activity have been developed for antioxidant research, showing good pharmacokinetics and microenvironmental tolerance, but there are still problems such as difficulty in precise targeted delivery and low utilization.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of multifunctional oxidation-resistant magnetic nanocomposite material and preparation method thereof
  • A kind of multifunctional oxidation-resistant magnetic nanocomposite material and preparation method thereof
  • A kind of multifunctional oxidation-resistant magnetic nanocomposite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 0.7g (35mg / mL) of ferric chloride hexahydrate, 100mg (5mg / mL) of lignin, and 1.8g (90mg / mL) of sodium acetate and dissolve them in 20mL of ethylene glycol, and seal the resulting mixed solution in a 50mL reaction vessel , reacted at 200°C for 10 h, and washed thoroughly with N,N-dimethylformamide and distilled water to obtain a nanocomposite material.

[0030] figure 1 , figure 2 They are the TEM image, the hydrated particle size and the surface potential test image of the nanocomposite material prepared in this example, respectively. Depend on figure 1 , figure 2 It can be seen that the prepared nanocomposite material presents the morphology of nanoclusters, the hydrated particle size is about 304nm, and the surface potential is about -20mV.

[0031] image 3 Test charts of the free radical scavenging rate of the nanocomposite prepared in this example at different concentrations. Depend on image 3 It can be seen that with the increase of concentration, ...

Embodiment 2

[0035]Weigh 0.2g (10mg / mL) of ferric chloride hexahydrate, 200mg (10mg / mL) of lignin, and 1g (50mg / mL) of sodium acetate and dissolve them in 20mL of ethylene glycol, and seal the resulting mixed solution in a 50mL reaction kettle , react at 180°C for 8h, and get the nanocomposite material after fully washing with N,N-dimethylformamide and distilled water.

Embodiment 3

[0037] Weigh 0.4g (20mg / mL) of ferric chloride hexahydrate, 300mg (15mg / mL) of lignin, and 1.4g (70mg / mL) of sodium acetate dissolved in 20mL of ethylene glycol, and seal the resulting mixed solution in a 50mL reaction vessel , reacted at 190°C for 9 hours, and washed thoroughly with N,N-dimethylformamide and distilled water to obtain a nanocomposite material. After testing, the SAR value of the nanocomposite material is 879W / g.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
surface potentialaaaaaaaaaa
Login to View More

Abstract

The present invention relates to a multifunctional anti-oxidation magnetic nano-composite material and a preparation method thereof. The nano-composite material is lignin-iron oxide synthesized in one step by a simple solvothermal method using ferric chloride hydrate and natural polymer lignin as raw materials bulk nanocomposites. Compared with the prior art, the nanocomposite material prepared by the present invention not only has excellent oxidation resistance and magnetic properties, but also has good biocompatibility, and can scavenge active free radicals with physical therapy and magnetic resonance based on magnetic field The combination of imaging and other functions makes it have broad application prospects in the treatment of oxidative stress-related diseases. In addition, based on the excellent magnetic actuation performance of the prepared nanocomposite, it also has great application potential in the fields of magnetic actuation motors and precise drug delivery.

Description

technical field [0001] The invention belongs to the technical field of nano biomedical materials, and relates to a multifunctional anti-oxidation magnetic nano composite material and a preparation method thereof. Background technique [0002] A large number of studies have shown that the oxidative stress response caused by the imbalance between the production of active free radicals and antioxidant defense in the body is related to the occurrence and process of various diseases, including aging, autoimmune diseases (such as type 1 diabetes, class 1 diabetes, etc.) Rheumatoid arthritis), cardiovascular diseases (such as atherosclerosis) and neurodegenerative diseases (such as Parkinson's disease, Alzheimer's disease), etc. Therefore, antioxidant therapy is recognized as a potential means to prevent and treat oxidative stress-related diseases. So far, a variety of small molecule antioxidants including vitamin E and catechol have been approved by the FDA for antioxidant therap...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61P39/06
CPCA61K41/0052A61P39/06
Inventor 成昱李珍光
Owner TONGJI UNIV