Bionic liver organ culture model and application thereof
An organoid and model technology, which is applied in the field of in vitro cell culture technology and drug toxicity screening to achieve the effects of unique structure, enhanced toxicity sensitivity, and enhanced liver specific function and metabolic function.
Pending Publication Date: 2020-04-03
江苏信安佳医疗科技有限公司
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Abstract
The invention relates to the fields of cell in-vitro culture technology and drug toxicity screening, in particular to construction of a bionic liver organ culture model and an application of the bionic liver organ culture model in drug toxicity evaluation. The invention provides a construction method of the bionic liver organ culture model, which comprises the following steps: respectively carrying out conventional cell culture and digestion on hepatocytes and endothelial cells to prepare cell suspensions, respectively inoculating the cell suspensions to a groove device and a porous membrane,assembling the porous membrane to the groove device, and culturing in an incubator to prepare the bionic liver organ culture model. The model is unique in structure, has double cells and double targets, can be used for toxicity evaluation of hepatocytes with main targets and toxicity evaluation of non-parenchyma endothelial cells, and provides a new thought and a powerful tool for drug toxicity screening.
Application Domain
HepatocytesMicrobiological testing/measurement +3
Technology Topic
Organ culturePorous membrane +10
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