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Quality testing method of Huatuo Fengtongbao Capsules, a national medicine of Zhuang medicine

A quality inspection method, the technology of Huatuo Fengtongbao, is applied in the directions of measuring devices, instruments, scientific instruments, etc., which can solve the problems of complex detection methods, easy interference detection, unfavorable promotion, etc., and achieves easy operation and good detection effect. , good repeatability

Active Publication Date: 2022-07-15
GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, the existing detection methods are relatively complicated, with poor accuracy, stability, repeatability and recovery rate, which are not practical enough and are not conducive to popularization; meanwhile, Huatuo Fengtongbao Capsules are powdered Chinese herbal medicines, which contain many impurities and are easy to detect. Interference with the detection of N-trans-feruloyl p-hydroxyphenethylamine and N-trans-feruloyl-5′-methoxy-6′-hydroxyphenethylamine, resulting in unsatisfactory detection results

Method used

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  • Quality testing method of Huatuo Fengtongbao Capsules, a national medicine of Zhuang medicine

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Embodiment 1

[0050] A method for testing the quality of Huatuo Fengtongbao Capsules, a national medicine of Zhuang medicine, comprising:

[0051] Step 1. After mixing the known quality Huatuo Fengtongbao Capsules with the solvent, centrifuge to obtain a supernatant; specifically: weigh 0.5g of Huatuo Fengtongbao Capsules, place them in a 50ml conical flask, and measure methanol 10ml was added to the conical flask as a solvent, the conical flask was sealed and the weight was weighed, ultrasonically treated for 30min (power 360w) and cooled to a normal temperature of 20-25°C, then weighed again, and the reduced weight was supplemented with methanol, shake well, The supernatant was obtained by centrifugation.

[0052]Step 2: After the supernatant is mixed with samples, packed into a column by wet method and loaded by a dry method, eluted to obtain an eluent, and then filtered to obtain a sample solution; specifically: taking the supernatant obtained in step 1 and placing it in an evaporating ...

Embodiment 2

[0058] A method for testing the quality of Huatuo Fengtongbao Capsules, a national medicine of Zhuang medicine, comprising:

[0059] Step 1. After mixing the known quality Huatuo Fengtongbao Capsules with the solvent, centrifuge to obtain a supernatant; specifically: weigh 0.5g of Huatuo Fengtongbao Capsules, place them in a 50ml conical flask, and measure methanol 10ml was added to the conical flask as a solvent, the conical flask was sealed and the weight was weighed, ultrasonically treated for 30min (power 360w) and cooled to a normal temperature of 20-25°C, then weighed again, and the reduced weight was supplemented with methanol, shake well, The supernatant was obtained by centrifugation.

[0060] Step 2: After the supernatant is mixed with samples, packed into a column by wet method and loaded by a dry method, eluted to obtain an eluent, and then filtered to obtain a sample solution; specifically: taking the supernatant obtained in step 1 and placing it in an evaporating...

Embodiment 3

[0067] A method for testing the quality of Huatuo Fengtongbao Capsules, a national medicine of Zhuang medicine, comprising:

[0068] Step 1. After mixing the known quality Huatuo Fengtongbao Capsules with the solvent, centrifuge to obtain a supernatant; specifically: weigh 0.5g of Huatuo Fengtongbao Capsules, place them in a 50ml conical flask, and measure methanol 10ml was added to the conical flask as a solvent, the conical flask was sealed and the weight was weighed, ultrasonically treated for 30min (power 360w) and cooled to a normal temperature of 20-25°C, then weighed again, and the reduced weight was supplemented with methanol, shake well, The supernatant was obtained by centrifugation.

[0069] Step 2: After the supernatant is mixed with samples, packed into a column by wet method and loaded by a dry method, eluted to obtain an eluent, and then filtered to obtain a sample solution; specifically: taking the supernatant obtained in step 1 and placing it in an evaporating...

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Abstract

The invention discloses a quality detection method for Huatuo Fengtongbao capsules, a national medicine of Zhuang medicine, comprising: after mixing Huatuo Fengtongbao capsules with a solvent, centrifuging to obtain a supernatant; After column packing and dry loading, the sample solution was eluted and filtered to obtain the sample solution; the sample solution was mixed with N-trans-feruloyl-p-hydroxyphenethylamine and N-trans-feruloyl-5'-methoxyl The reference substance solutions of the two active ingredients of ‑6'‑hydroxyphenethylamine were detected by liquid chromatography respectively to obtain the peak area of ​​the sample solution and the peak area of ​​the reference substance solution; the Zhuang medicine national medicine Huatuo Fengtongbao Capsule was calculated by the formula The mass fraction of the active ingredients in it to determine the quality. Only four steps of the present invention can detect the content of active ingredients in Huatuo Fengtong Capsules, and then judge the quality of Huatuo Fengtong Capsules, the operation is very simple and easy, and the accuracy, stability, repeatability and recovery rate are good , strong practicability, very suitable for promotion and use.

Description

technical field [0001] The invention belongs to the technical field of drug quality detection, and in particular relates to a quality detection method for Huatuo Fengtongbao capsules, a Zhuang medicine national medicine. Background technique [0002] Zhuang medicine national medicine Huatuo Fengtongbao Capsule is mainly composed of 6 traditional Chinese medicinal materials such as red fish eye and nine layers of wind. The content of the capsule is brown-black powder with a bitter taste. It is used for rheumatic arthralgia, limb flexion and extension. Unfavorable, muscle spasm, joint swelling and pain adaptation symptoms. [0003] At present, the quality control of Huatuo Fengtongbao Capsules is mainly accomplished by controlling the composition ratio of Chinese herbal medicines. Due to the quality difference of Chinese herbal medicines, the content of active ingredients in the prepared Huatuo Fengtongbao Capsules varies greatly, so the product quality cannot be effectively ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/14
CPCG01N30/02G01N30/14G01N2030/047G01N2030/146
Inventor 闫炳雄宋志军姚彩云刘喜慧宋姗珊吴云秋
Owner GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS