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Peripheral blood methylation gene and IDH1 combined detection and diagnosis model for lung cancer

A technology of IDH1 and methylation, applied in the medical field, to achieve the effect of improving diagnostic efficiency and enhancing diagnostic efficiency

Active Publication Date: 2020-05-19
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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Problems solved by technology

However, the conclusion of this study was drawn in a population with a relatively high proportion of non-adenocarcinoma (adenocarcinoma:non-adenocarcinoma, 1:1.5), which is consistent with the current epidemiology of lung cancer in which patients with lung adenocarcinoma are the main affected population. characteristics do not match

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  • Peripheral blood methylation gene and IDH1 combined detection and diagnosis model for lung cancer
  • Peripheral blood methylation gene and IDH1 combined detection and diagnosis model for lung cancer
  • Peripheral blood methylation gene and IDH1 combined detection and diagnosis model for lung cancer

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Embodiment 1

[0049] Example 1. Establishment and application of a lung cancer model diagnosed by combined detection of methylated genes and IDH1

[0050] 1. Research population

[0051] The methylation levels of SHOX2 and PTGER4 genes in the DNA of peripheral blood samples were measured and statistically analyzed in the samples of healthy controls and lung cancer patients, and the content of IDH1 protein in serum was detected. From January 2017 to December 2018, 221 subjects from the Cancer Hospital of the Chinese Academy of Medical Sciences were included in the study of the present invention and randomly divided into a modeling group and a verification group.

[0052] Blood samples were collected from lung cancer patients meeting the following criteria: (a) no history of other specific malignancies: (b) no anticancer treatment prior to the blood collection procedure.

[0053] The healthy people in the control group were selected from the physical examination center at the same time; as c...

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Abstract

The invention discloses a peripheral blood methylation gene and IDH1 combined detection and diagnosis model for lung cancer. The invention provides application of methylated SHOX2 gene, methylated PTGER4 gene and IDH1 protein as markers in preparation of products for diagnosis or auxiliary diagnosis of lung cancer, and constructs a three-marker combined lung cancer diagnosis model. Experiments prove that: compared with an incorporated single factor, the diagnosis efficiency of the combined diagnosis model is remarkably enhanced. Therefore, the diagnosis efficiency of the lung cancer can be improved by combined detection blood markers.

Description

technical field [0001] The invention relates to the medical field, in particular to a lung cancer model for the combined detection and diagnosis of peripheral blood methylation genes and IDH1. Background technique [0002] With the continuous development of medical technology, people have made great progress in the diagnosis and treatment of malignant tumors, but lung cancer is still the main cause of cancer death in men and women all over the world. On the other hand, although low-dose computed tomography (LDCT) has proven superiority in screening for lung cancer compared to plain mammography, only 4% of patients in the high-risk population are screened each year. In addition, for some pulmonary nodules with atypical imaging manifestations, the diagnostic specificity of LDCT is not high, so repeated imaging examinations are required to observe the changes of pulmonary nodules for a long time, resulting in the continuous increase of national medical and health expenses , in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/574G01N33/573G16B5/00G16B20/00
CPCC12Q1/6886G01N33/57423G01N33/57488G01N33/573G16B5/00G16B20/00C12Q2600/154G01N2333/904
Inventor 赫捷高树庚孙楠臧若川
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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