Preparation method and application of Thais clavigera Kuster polysaccharide

A technology of lychee verruca and lychee snail, applied in the field of medicine, can solve the problems of few research results of anti-hepatitis B virus and liver protection, and there is no relevant report, and achieves significant anti-hepatitis B activity and the effect of reducing the content.

Active Publication Date: 2020-05-29
HUAQIAO UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern medical research shows that the conch has a good anti-inflammatory effect, but there are still relati

Method used

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  • Preparation method and application of Thais clavigera Kuster polysaccharide
  • Preparation method and application of Thais clavigera Kuster polysaccharide
  • Preparation method and application of Thais clavigera Kuster polysaccharide

Examples

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Embodiment 1

[0038] A preparation method of snail snail polysaccharide, comprising the steps of:

[0039] (1) Degreasing the snail powder with n-hexane to obtain defatted snail powder, specifically: take 300g of the above-mentioned snail powder, add n-hexane in a rapid extractor in an appropriate proportion, and extract 1- 2min, repeat 3 times, discard the clear bright yellow solution after suction filtration, take the precipitate, which is the snail powder after degreasing, and dry it for later use;

[0040] The preparation method of the snail powder includes: washing the fresh snails of uniform size to remove the sediment, heating and boiling in clean water for 3-5 minutes, cooling in cold water rapidly, picking out the edible fleshy parts in time, and discarding the rest Put the edible meat part in the refrigerator to freeze for at least 24 hours, then quickly take it out and put it in a vacuum freeze-drying box for 24-48 hours until it is completely dry, then put it in a traditional Ch...

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Abstract

The invention discloses a preparation method and an application of Thais clavigera Kuster polysaccharide. The method comprises the following steps: taking fresh Thais clavigera Kuster as an initial material, boiling with water, removing shells, taking meat, carrying out vacuum freeze drying treatment, and carrying out alkaline water extraction, ethanol precipitation, protease enzymolysis, macroporous resin decolorization and ultrafiltration to obtain the refined polysaccharide component of which proteins and pigments are removed and the molecular weight is greater than 10 kD. The Thais clavigera Kuster polysaccharide prepared in the invention has remarkable anti-hepatitis B activity, can remarkably reduce the content of glutamic-pyruvic transaminase (ALT) and glutamic oxalacetic transaminase (AST) in serum, and plays a great role in protecting the liver.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method and application of snail snail polysaccharide. Background technique [0002] Hepatitis B virus (HBV) is a typical hepatophagic DNA virus. Chronic infection with HBV will lead to liver fibrosis, cirrhosis, hepatic insufficiency, and even liver cancer. Hepatitis B is a chronic necrotic disease caused by hepatitis B virus (HBV) infection, which has become a major public health problem in the world, and the liver cancer caused by it ranks fifth among all malignant tumors. Inhibiting or killing hepatitis B virus plays an extremely important role in the treatment of hepatitis B. Currently, there are two types of drugs clinically used in the treatment of chronic hepatitis B virus: one is immunomodulators, which have a low response rate and large side effects; the other is nucleotide analogs, which are prone to accumulate drug resistance and have a long...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P31/20
CPCA61K31/715A61P31/20C08B37/0003
Inventor 崔秀灵唐飞许瑞安殷虹黄光华
Owner HUAQIAO UNIVERSITY
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