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Stable cannabinoid compositions

A technology of cannabinoids, compositions, applied in the field of compositions containing lipophilic bioactive compounds, capable of solving problems such as low potency, insufficient shelf life, and reduced availability of ingredients in emulsions, to achieve high potency, high usage, enhanced Effect of stability against light and/or thermal degradation

Inactive Publication Date: 2020-06-05
SOLMIC BIOTECH GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these emulsions may also have low potency due to their instability in the intestinal tract, where the emulsion can "break" due to dilution below the critical micelle concentration, and thus destabilize the micellar formulation
[0009] The above-mentioned problems are further exacerbated in liquid or gel-like formulations, which in most cases exhibit insufficient shelf-life because, when compared to solid forms such as lozenges or capsules, due to light and oxygen exposure, Degradation of the ingredients to be emulsified further reduces the availability of the ingredients in the emulsion

Method used

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  • Stable cannabinoid compositions
  • Stable cannabinoid compositions
  • Stable cannabinoid compositions

Examples

Experimental program
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Effect test

Embodiment

[0080] Put 18 parts by weight of vitamin E polyethylene glycol succinate into a beaker and heat to a temperature of 70 to 80° C. until the first light yellow transparent melt is formed. For this melt, 1 part by weight of DL-α-tocopherol (commercially available from BASF Germany) was added to the first melt while maintaining the temperature at 40 to 55°C until a second yellowish transparent melt was formed. Subsequently, 1 part by weight of cannabidiol as a natural extract or a synthetic component was added to the second melt while maintaining the temperature at 40 to 55° C. until the cannabidiol was dissolved, thereby forming a third yellowish transparent melt. Then, 80 parts by weight of an aqueous solution containing 0.1 parts by weight of potassium sorbate and 0.05 parts by weight of citric acid was preheated to a temperature of 40 to 55° C., and added to the third melt under stirring to dissolve the water Dispersed in a third melt and formed a yellowish clear gel which was...

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Abstract

A composition comprising a cannabinoid, in particular a phytocannabinoid or a synthetic cannabinoid, where the cannabinoid is stabilised against oxidation and / or photochemical degradation, characterized in that the composition comprises a micellar solution of composite micelles in an aqueous solution and where the composite micelles encapsulate the cannabinoid.

Description

technical field [0001] The present invention relates to compositions comprising lipophilic bioactive compounds, such as cannabinoids, wherein the cannabinoids are stabilized against oxidative and / or photochemical degradation. Background technique [0002] Pharmaceutical formulations allow active ingredients to enter the body and reach target tissues so that they can perform their intended effects in the body. When an active ingredient must be administered via a given route, the physical and chemical properties of the active ingredient and its formulation should be fully considered. [0003] For example, the ability of an active ingredient to be taken up through the gut via the oral route, ie to enter the systemic circulation, depends largely on its stability to acid (gastric juice), enzymatic degradation (eg pancreatic enzymes) and water solubility. [0004] Likewise, uptake through the skin depends on the ability of the active ingredient to bypass the upper skin layer cons...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/22A61K31/05A61K31/352
CPCA61K9/1075A61K9/0053A61K9/0014A61K45/00A61K31/05A61K31/352A61K31/015A61K47/22A61K47/10A61K31/658A61K31/355A61K2121/00A61K2300/00
Inventor 伊尔莎·克内勒托马斯·佐维克
Owner SOLMIC BIOTECH GMBH
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