Application of melatonin and mecobalamin in treatment of diabetic wound healing disorders
A technology for wound healing and diabetes, applied in the field of biomedicine, to achieve the effect of promoting healing
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[0053] 1 Materials and methods
[0054] 1.1 Experimental animals
[0055] Twenty-four male SD rats (weight: 220 ± 20 g) aged about 8 weeks were purchased from the Experimental Animal Center of Shandong University. The experimental protocol has been approved by the Animal Experiment Ethics Committee of Shandong University School of Medicine (No. Authorization, the experiment strictly complied with the "Guidelines for Animal Care and Treatment" (eighth edition, 2011).
[0056] 1.2 Experimental materials and reagents
[0057] Melatonin (M5250-1G; Sigma-Aldrich, St.Louis, MO, USA); Mecobalt (Shanghai Aibison Biotechnology Co., Ltd.).
[0058] 1.3 Preparation of SD rat diabetic model and diabetic wound model
[0059] Fasting without food and water for 12 hours before modeling, blood glucose was measured at the end of the next morning. Subsequently, the hyperglycemia model was induced by intraperitoneal (i.p.) injection of streptozotocin (STZ; 75 mg / kg; Sigma-Aldrich, St) for th...
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