In-situ separation detection nuclear magnetic resonance radio frequency probe front end and preparation method thereof

Abstract

The invention relates to an in-situ separation detection nuclear magnetic resonance radio frequency probe front end and a preparation method thereof. A charged particle filtering pipeline, a separatedwaste liquid discharging pipeline and a sample detection pipeline are matched with a bifurcated shunting manner; in a magnetic field environment in the vertical direction, charged paramagnetic particles are subjected to the action of lorentz force outwards in the radial direction, and can be effectively and accurately shunted at the intersection of the charged particle filtering pipeline, the separation waste liquid discharging pipeline and the sample detection pipeline, so that a separated solution with the paramagnetic particles is discharged from the separated waste liquid discharging pipeline. The in-situ separation detection nuclear magnetic resonance radio frequency probe front end has a simple and efficient magnetic substance filtering and separating structure, has a flexible customized sample pipeline design, is convenient to modify and adjust according to experimental requirements, effectively improves the detection signal-to-noise ratio, and can meet the requirements of various in-situ magnetic resonance imaging detections. 3D printing is adopted for preparation, the design flexibility can be improved, the efficiency can be greatly improved, and the labor cost is reduced.

Description

technical field [0001] The invention relates to the technical field of nuclear magnetic resonance, and more particularly, to an in-situ separation detection nuclear magnetic resonance radio frequency probe front end, and a preparation method of the in-situ separation detection nuclear magnetic resonance radio frequency probe front end. Background technique [0002] Nuclear magnetic resonance is non-destructive and is an important means of modern analysis and detection technology. It has been widely used in many fields such as physics, chemistry, biology, medicine and food testing. As one of the core components of NMR equipment, the front end of the RF probe composed of RF coils, RF circuits and pipelines in the sample detection area largely determines the experimental performance of the instrument. [0003] The nuclear magnetic resonance radio frequency coil can convert the pulse sequence electrical signal into a high-frequency electromagnetic field acting on the sample, so ...

AI Technical Summary

Problems solved by technology

However, for the reaction of magnetic substances, only the conventional external non-situ separation and filtration technology can be used, so the in-situ NMR monitoring of the experimental system cannot be carried out, which makes the relevant detection and analysis difficult.

[0010] Most of the existing in-situ separation technologies need to add additional devices, perform complex construction operations, or create a special separation environment, and it is difficult to apply to in-situ NMR detection with strong magnetic fields and small cavities.

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