Pharmaceutical manufacturing installation and method of manufacturing of pharmaceutical product
A facility and substance technology, applied in the field of pharmaceutical product manufacturing, which can solve problems such as difficulty in adapting to automatic measurement, and achieve the effect of low impact of product classification, measurement/reliability, and robust measurement
Active Publication Date: 2020-06-12
F HOFFMANN LA ROCHE & CO AG
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Problems solved by technology
However, it is only suitable for bands of sufficient quality and requires careful consideration of environmental impact
However, all of the above techniques are still relatively difficult to adapt to inline / inline / online automated measurements in pharmaceutical facilities where they can be used as process analytical techniques
Method used
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[0058] In order to avoid repetition of the drawings and description of the various aspects and exemplary embodiments, it is to be understood that many features are common to the various aspects and embodiments. Omission of an aspect from the description or drawings does not mean that that aspect is missing from embodiments incorporating that aspect. Rather, this aspect may be omitted for clarity and to avoid a lengthy description. In this context, the following applies to the rest of the description: If, for the sake of clarity, a drawing contains reference signs that are not stated in the directly relevant part of the description, reference can be made to this in a preceding or following descriptive section. Reference sign. Furthermore, if not all features of a component are provided with a reference number in one figure for clarity, reference is made to other figures showing the same component. Like numbers in two or more figures indicate the same or similar elements.
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Abstract
A pharmaceutical manufacturing installation (23), comprising a processing equipment (21) arranged to provide a pharmaceutical substance (4) in a solid state and a solid fraction sensor (17) having a first conductor element (5), a second conductor element (7), an operation space (15), an energy source (13) arranged to generate an electric field in the operation space (15) by means of the first conductor element (6) and the second conductor element (8), and a controller (11) adapted to determine a capacitance between the first and second conductor element (5, 7) of the pharmaceutical substance (4) in the solid state located in the operation space (15), wherein the solid fraction sensor (17) is arranged to receive the pharmaceutical substance (4) in its solid state into the operation space bythe processing equipment (21).
Description
technical field [0001] The invention relates to a pharmaceutical facility comprising a processing device arranged to provide a pharmaceutical substance in a solid state and a solids fraction sensor, and furthermore to a method of manufacturing a pharmaceutical product. Background technique [0002] The porosity of a solid has a great influence on its mechanical properties and is therefore of great importance in many industries including the pharmaceutical, chemical or food industries. In pharmaceutical manufacturing, the porosity of intermediates also affects the porosity of the final solid dosage form, which in turn affects its disintegration and dissolution behavior. Therefore, the porosity of intermediates and final dosage forms plays an important role in the bioavailability of drug products. [0003] Mesoporosity is particularly important in dry granulation of powder mixtures via roller compaction and in tabletting. In roll compaction, the powder mixture is first press...
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IPC IPC(8): A61J3/10G01N27/22G01N33/15
CPCA61J3/10G01N27/221G01N33/15B30B11/006B30B11/005G01N21/9508
Inventor J·西比克P·沙吕
Owner F HOFFMANN LA ROCHE & CO AG