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PH-targeted flexible nano-liposome with acne removing effect and preparation method of pH-targeted flexible nano-liposome

A nano-liposome and anti-acne technology, applied in the field of medicine, can solve problems such as poor treatment and skin care effects, difficulty entering the dermis, and complex active ingredients, so as to improve solubility and stability, inhibit excessive oil secretion, and inhibit The effect of the growth of the associated flora

Inactive Publication Date: 2020-06-16
程定义
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The active ingredients in traditional skin care products are complex, and many of them are macromolecules, which can only stay on the skin surface or epidermis, and it is difficult to enter the dermis, and the skin penetration rate is extremely low, only 5%.
Common acne inflammations (such as pimples, cysts, and lumps) erode into the dermis, and ingredients with low transmittance are difficult to reach the inflammation site, and the treatment and skin care effects are often poor

Method used

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  • PH-targeted flexible nano-liposome with acne removing effect and preparation method of pH-targeted flexible nano-liposome
  • PH-targeted flexible nano-liposome with acne removing effect and preparation method of pH-targeted flexible nano-liposome
  • PH-targeted flexible nano-liposome with acne removing effect and preparation method of pH-targeted flexible nano-liposome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] In this embodiment, the pH-targeted flexible nanoliposomes coated with acne-removing active ingredients are flexible nanoliposomes coated with phloretin, that is, the pH-targeted flexible nanoliposomes are coated with phloretin, and the root Cortexin is the active ingredient for acne.

[0036] (1) A pH-targeted flexible nanoliposome coated with phloretin, comprising the following raw materials:

[0037] N-octanoyl-D-sphingosine 14.4wt%, β-sitosterol 1.8wt%, Poloxamer 124 1.5wt%, poly(N-n-butylacrylamide) 1.6wt%, phloretin 7.6wt% and PEG-400 11.2wt%, the balance is the hydration solution.

[0038] (2) A preparation method of pH targeted flexible nanoliposomes coated with phloretin, comprising the steps of:

[0039] (1) Quantitatively weigh N-octanoyl-D-sphingosine, β-sitosterol, poloxamer 124, poly(N-n-butylacrylamide), and phloretin dissolved in In the organic solvent, the organic solvent is a mixed solution of methanol and chloroform (v:v=3:1);

[0040] (2) Under t...

Embodiment 2

[0045] In this example, the pH-targeted flexible nanoliposomes coated with acne-removing active ingredients are flexible nanoliposomes coated with Centella asiatica extract, that is, the pH-targeted flexible nanoliposomes are coated with Centella asiatica Extract, Centella asiatica extract is the active ingredient for acne.

[0046] (1) A pH-targeted flexible nanoliposome coated with Centella asiatica extract, comprising the following raw materials:

[0047] N-octanoyl-D-sphingosine 18.9wt%, β-sitosterol 1.8wt%, cetyl palmitate 2.9wt%, polyethylene glycol-hydrazone bond-polystyrene copolymer 2.1wt% , Centella asiatica extract 10.6wt%, PEG-400 12.4wt%, the balance is hydration solution.

[0048] (2) A preparation method for coating Centella asiatica extract pH-targeted flexible nanoliposomes, comprising the steps of:

[0049] (1) Quantitatively weigh N-octanoyl-D-sphingosine, β-sitosterol, cetyl palmitate, polyethylene glycol-hydrazone bond-polystyrene copolymer and snow asia...

Embodiment 3

[0055] In this example, the pH-targeted flexible nanoliposomes coated with acne-removing active ingredients are flexible nanoliposomes coated with hop extract and Polygonum cuspidatum root extract, that is, pH-targeted flexible nanoliposomes coated There are hop extract and knotweed root extract, and hop extract and knotweed root extract are active ingredients for acne.

[0056] (1) The composition of a pH-targeted flexible nanoliposome coating hop extract and Polygonum cuspidatum root extract is as follows:

[0057] N-octanoyl-D-sphingosine 21.6wt%, β-sitosterol 2.2wt%, Poloxamer 124 3.6wt%, ethoxylated-C 12-18 -Alcohol 1.2wt%, poly(N-n-butylacrylamide) 1.6wt%, diethylhexyl maleate 0.8wt%, hop extract 6.9wt%, Polygonum cuspidatum root extract 3.4wt%, PEG-400 9.8wt%, the balance is the hydration solution.

[0058] (2) a preparation method of pH-targeted flexible nanoliposomes coated with hop extract and Polygonum cuspidatum root extract, comprising the steps of:

[0059] (1...

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Abstract

The invention relates to a pH-targeted flexible nano-liposome with an acne removing effect and a preparation method thereof. A acne-removing active component is coated with a flexible nano-liposome, and the acne-removing active component comprises one or a mixture of several of a centella asiatica extract, an azadirachta indica leaf extract, a humulus lupulus extract, a polygonum cuspidatum root extract, a herba portulacae extract, a radix scutellariae root extract and phloretin. The flexible nano-liposome can be added into an external preparation, the dilemma that effective components in theexternal preparation are low in skin transmittance, free of targeting and poor in safety is improved by utilizing the deformability of the flexible nano-liposome, and the preparation method is simpleand convenient and is suitable for preparation of similar flexible nano-liposomes.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pH-targeting flexible nano-liposome with anti-acne effect and a preparation method thereof. Background technique [0002] "Acne", also known as acne, is a chronic inflammatory disease involving skin hair follicles and sebaceous glands. It is mainly related to excessive sebum secretion, blockage of pilosebaceous gland ducts, bacterial infection and inflammatory reactions. The clinical manifestations are the face and other areas with more sebum Comedones, papules, pustules, nodules appear. The cells in the stratum corneum of the outermost layer of the skin are tightly connected, forming a "brick wall structure" with the lipids in the intercellular space, providing a tight and effective physical barrier for the skin. The active ingredients in traditional skin care products are complex, many of which are macromolecules, which can only stay on the skin surface or epide...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K47/18A61K47/28A61K47/10A61K31/12A61K36/23A61K36/704A61P17/10
CPCA61K9/0014A61K9/1271A61K31/12A61K36/23A61K36/704A61K47/10A61K47/18A61K47/28A61P17/10
Inventor 王立强张嘉颖
Owner 程定义
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