Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye

A treatment composition and composition technology, applied in drug combination, physical therapy, disease diagnosis, etc., can solve the problem that there is no systematic and logical method for dry eye syndrome, and achieve easy practice, increased safety and comfort , reduce the effect of side effects and/or allergic reactions

Inactive Publication Date: 2020-06-16
AKRIVISTA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there is no systematic and logical approach available to treat dry eye in individual patients

Method used

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  • Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye
  • Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye
  • Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0218] A series of different artificial tear treatment compositions were prepared. The therapeutic compositions according to the present invention are each suitable for the treatment of dry eye syndrome in humans.

[0219] ___________________

[0220] Table 1

[0221] Composition w / v%

[0222]

[0223]

[0224] As can be seen from the above, in some of the exemplified compositions (eg compositions G, H and L) a single oil is used, while in other compositions (compositions K, M and N) more than one oil is used , and in yet other compositions (Compositions I and J), no oil was used. Thus, a variety of dry eye therapeutic compositions can be prepared, each tailored to a different set of patient symptoms and tear properties. Although all compositions exemplified herein contain antimicrobial agents (BAK or sodium chlorite), it is to be understood that preservative-free (eg, sterile) forms of these or other compositions can also be prepared. Optionally, a viscosity-indu...

example 2

[0227] A group of patients were combined, selected for testing to determine the presence or absence of dry eye syndrome, each patient indicating that he / she was experiencing some degree of eye discomfort.

[0228] The test is performed by qualified medical personnel experienced in identifying the presence and severity of dry eye syndrome in a patient's eye. Tear fluid was collected, quantified, and analyzed for pH, osmolality, protein content, hydrophobic / hydrophilic balance, and viscosity, and compared to the mean of dry eye-unaffected individuals.

[0229] As a result of this test, it was determined that some people did not have dry eye syndrome, while others did. Specifically, among those identified as having dry eye syndrome, subgroups can be identified.

[0230] Patients in subgroup A had less than normal amounts of tears, but normal protein levels, indicating that the mucus (viscous) layer of tears was intact, the osmolality was within the normal range, and the differen...

example 3

[0240] A set of different eye skin care base compositions O to Y as shown in the table below were prepared. Each eye skin care base composition can be used alone to condition and hydrate the skin, or alternatively, as a basis for the addition of cosmetic additives such as eye shadow or eyeliner pigments and other ingredients, for patients with dry eye syndrome or to prevent eyes Stimulate.

[0241] ___________________

[0242] Table 2

[0243] Composition eye / skin w / v %

[0244]

[0245] In this example, (a group of acrylate polymers) formulations containing 80. If using then only add extra when necessary 80 to reach a final concentration of 0.25% (w / v). In addition, in these examples, the thickener should be or HPMC, CMC (carboxymethyl cellulose) are adjusted to each other in the respective ratios given here in order to achieve the desired viscosity.

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Abstract

In preferred the invention is directed to ocular compositions for the treatment of dry eye, methods for making such compositions, and suites comprising a plurality of different ocular compositions each having a defined composition. In preferred examples, the invention is directed to compositions comprising at least one natural oil, wherein a first member of the suite of compositions is effective in treating dry in in a first patient having a particular set of symptoms and a different second member of the suite of compositions is effective in treating dry in in a second patient having a different set of symptoms. The invention is also directed to methods of making and using the compositions, and to skin care compositions for use around the eye, such as the upper and lower eyelids having a lubricating, non-irritating base composition comprising at least one natural oil.

Description

[0001] Related applications [0002] This application claims priority to Provisional Patent Application No. 62 / 547,553, filed on August 18, 2018. Background technique [0003] The present invention relates to methods of diagnosing and treating dry eye syndrome in the human eye, as well as compositions designed for the treatment of diagnosed dry eye syndrome. More specifically, the present invention relates to methods comprising conducting a test to determine whether a human patient suffers from dry eye syndrome and, if so, to determine the extent or severity of dry eye syndrome in one or both eyes of said patient Asking the patient about susceptibility and / or other questions the patient has about dry eye syndrome that may affect treatment of the eye with medications; and providing a therapeutic composition to treat the eye based on the testing and inquiries patients with dry eye syndrome. "Therapeutic composition" means a topical ophthalmic formulation developed as a treatm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61H35/02A61K36/18A61P27/04
CPCA61K9/0048A61K9/0014A61K47/44A61K8/922A61Q19/005A61P27/04A61P27/02A61K36/752A61K36/185A61K36/235A61K36/47A61K36/534A61K36/54A61K36/61A61K47/32A61K9/1075G01N33/50G01N2800/16
Inventor 斯科特·怀特卡普奥雷斯特·欧莱伊尼克迈克尔·加斯特彼得·A·西蒙斯
Owner AKRIVISTA LLC
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