Method for preparing water-soluble phytosterol nano-dispersion system with intestinal targeting release function

A phytosterol and nano-dispersion technology, applied in the directions of organic active ingredients, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of inability to exert transportation effect and sensitivity, and increase bioavailability. , Broaden the scope of application and improve the effect of stability

Inactive Publication Date: 2020-06-19
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there are still some problems with the above-mentioned nanoemulsions, such as: zein nanoparticles are highly sensitive to ionic strength and pH value, and will aggregate and precipitate rapidly even at low salt content, resulting in poor transport during digestion Effect

Method used

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  • Method for preparing water-soluble phytosterol nano-dispersion system with intestinal targeting release function
  • Method for preparing water-soluble phytosterol nano-dispersion system with intestinal targeting release function
  • Method for preparing water-soluble phytosterol nano-dispersion system with intestinal targeting release function

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Embodiment 1

[0037] A preparation method of a water-soluble phytosterol nano-dispersion system with intestinal targeted release function, the specific steps are as follows:

[0038] (1) Dissolve 10 mg of stigmasterol in 5 mL of absolute ethanol to prepare a stigmasterol solution with a mass concentration of 2 mg / mL, and then place the stigmasterol solution in a 45°C water bath to facilitate dispersion.

[0039] (2) Take 5 mg of pectin and pre-dissolve it in 10 mL of deionized water, add ethanol to it to 50 mL to obtain an ethanol aqueous solution with a volume fraction of 0.1 mg / mL pectin and a volume fraction of 80%; then dissolve 50 mg of corn in alcohol The protein was added to the above 80% aqueous ethanol solution to obtain a zein pectin solution.

[0040] (3) Mixing the stigmasterol solution in step (1) with the zein pectin solution in step (2) by ultrasonic treatment, and preparing a nano-dispersion (ie: nanoparticles);

[0041] Ultrasonic conditions are: FS-1200pv probe type ultra...

Embodiment 2

[0045] A preparation method of a water-soluble phytosterol nano-dispersion system with intestinal targeted release function, the specific steps are as follows:

[0046] (1) Dissolve 10 mg of stigmasterol in 5 mL of absolute ethanol to prepare a stigmasterol solution with a mass concentration of 2 mg / mL, and then place the stigmasterol solution in a 45°C water bath to facilitate dispersion.

[0047] (2) Take 10 mg of pectin and pre-dissolve it in 10 mL of deionized water, add ethanol to it to 50 mL, and obtain an ethanol aqueous solution with a volume fraction of 0.2 mg / mL pectin and a volume fraction of 80%; then dissolve 50 mg of corn in alcohol The protein was added to the above 80% aqueous ethanol solution to obtain a zein pectin solution.

[0048] (3) Mixing the stigmasterol solution in step (1) with the zein pectin solution in step (2) by ultrasonic treatment, and preparing a nano-dispersion (ie: nanoparticles);

[0049] Ultrasonic conditions are: FS-1200pv probe type ultr...

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Abstract

The invention discloses a method for preparing a water-soluble phytosterol nano-dispersion system with an intestinal targeting release function. The method comprises the following steps: preparing a phytosterol solution; preparing a pectin-containing ethanol water; adding zein into the pectin-containing ethanol water to obtain a zein pectin solution; mixing the phytosterol solution and the zein pectin solution by adopting an ultrasonic treatment mode to obtain a nano-particle dispersion liquid; performing rotary evaporation on the nano-particle dispersion liquid to remove organic solvent and water to obtain a zein / pectin-loaded phytosterol nano-dispersion system. According to the method, the ultrasonic method and anti-solvent method are adopted, the pectin ingredient is added based on thezein serving as an embedding medium, formation of a compact interface structure is further promoted on the basis of ensuring effective embedding of the zein on the phytosterol, and the stability of the nano-dispersion system is improved.

Description

technical field [0001] The invention relates to the technical field of preparation of water-soluble phytosterols, in particular to a preparation method of a water-soluble phytosterol nano-dispersion system with intestinal targeted release function. Background technique [0002] The molecular structure of phytosterols is similar to that of cholesterol, and consuming foods rich in phytosterols is an effective way to lower cholesterol. Since most phytosterols are insoluble in fat and insoluble in water, it is difficult to directly add phytosterols to food or medicine, which will affect their application. [0003] At present, researchers have used modification methods such as emulsification, embedding, and loading to significantly enhance the water solubility of phytosterols, and operations such as esterification can increase their fat solubility, making them applicable to more fields. [0004] Zein, the major storage protein in maize, can self-assemble into nanoparticles with ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/36A61K47/42A61K31/575A23L33/11
CPCA61K9/5161A61K9/5169A61K31/575A23L33/11A61K9/10A61K47/36A61K47/42
Inventor 冯思敏王丹邵平孙培龙
Owner ZHEJIANG UNIV OF TECH
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