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Biological sample laser cutting automatic separation device and separation method

A biological sample, laser cutting technology, applied in the direction of measuring devices, laser welding equipment, material excitation analysis, etc., can solve the problems of complex operation, inability to realize automation and assembly line operation, etc., and achieve high sampling efficiency and sampling accuracy.

Pending Publication Date: 2020-07-03
GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method not only needs to attach the film, but also needs to manually separate and cut the target cells or target tissues. The operation is complicated and cannot be automated and pipelined.

Method used

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  • Biological sample laser cutting automatic separation device and separation method
  • Biological sample laser cutting automatic separation device and separation method
  • Biological sample laser cutting automatic separation device and separation method

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Embodiment Construction

[0030] In order to make the technical problems solved by the present invention, the technical solutions adopted and the technical effects achieved clearer, the technical solutions of the embodiments of the present invention will be further described in detail below in conjunction with the accompanying drawings. Obviously, the described embodiments are only the technical solutions of the present invention. Some, but not all, embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative efforts fall within the protection scope of the present invention.

[0031] In the description of the present invention, unless otherwise clearly specified and limited, the terms "connected", "connected" and "fixed" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integrated ; It can be a mechanical connection or an electrical connection; it can be a direct...

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Abstract

The invention relates to a biological sample laser cutting automatic separation device and a separation method. The separation device comprises a workbench, wherein a sample carrying plate is arrangedabove the workbench at an interval, the sample carrying plate is connected with a first driving piece so as to enable the sample carrying plate to move along a plane parallel to the workbench, a plurality of grooves are concavely formed in the side, which is away from the workbench, of the sample carrying plate, the groove bottom of each groove is arranged in a light-transmitting manner, the grooves are used for carrying a biological sample marked by fluorescence, the workbench is further provided with a fluorescence microscopic imaging system and a laser cutting system, the fluorescence microscopic imaging system is used for realizing fluorescence excitation and imaging of the biological sample, the laser cutting system is used for cutting the biological sample according to imaging, anda sampling mechanism is arranged above the sample carrying plate and is connected with a second driving piece, so that the sampling mechanism moves to remove cut target samples in the grooves out of the grooves. The separation device is simple in structure, can automatically cut the biological sample, and enables the cut target samples to be automatically separated.

Description

technical field [0001] The invention relates to the technical field of biological sample separation, in particular to a biological sample laser cutting automatic separation device and separation method. Background technique [0002] The current laser microdissection (Laser Microdissection, LMD) technology uses a high-frequency low-energy pulsed ultraviolet laser to cut biological samples to minimize the loss of samples. The principle of laser microdissection technology is: quickly confirm the precise position of the target cell or target tissue by means of fluorescent labeling microscopic imaging, precisely control the coaxial ultraviolet laser for microdissection according to the position coordinate parameters, and combine the safety of membrane adhesion separation Sexually achieve the separation of target cells or target tissues into the culture dish. At present, biological samples are placed on a glass carrier before separation, and then attached with a support film. Dur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28G01N21/64G01N21/01B23K26/38
CPCG01N1/286G01N21/6458G01N21/6452G01N21/645G01N21/6428G01N21/6402G01N21/01B23K26/38G01N2001/2886G01N2021/6471G01N2021/6478G01N2021/6463G01N2021/6439G01N2021/0112
Inventor 张骁李俞锋骆健忠樊科范卫华温晓慧
Owner GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
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