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Bipolar affective disorder biomarkers based on enteric microorganism and screening and application thereof

A bipolar disorder and biomarker technology, applied in biostatistics, bioinformatics, instruments, etc., can solve problems such as worsening prognosis, increasing the complexity and refractory treatment, and hindering the risk identification of bipolar disorder , with high sensitivity and specificity

Active Publication Date: 2020-07-17
ZHEJIANG UNIV
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Problems solved by technology

[0003] Although current research suggests that the occurrence of bipolar disorder is the result of the interaction of genetic and environmental factors, the diagnosis of bipolar disorder is still based on symptomatic assessment, and there is still a lack of reliable biomarkers, which hinder the development of bipolar disorder. Disorders in risk identification, greatly increasing the complexity and refractory treatment of the disease, worsening the prognosis

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  • Bipolar affective disorder biomarkers based on enteric microorganism and screening and application thereof
  • Bipolar affective disorder biomarkers based on enteric microorganism and screening and application thereof
  • Bipolar affective disorder biomarkers based on enteric microorganism and screening and application thereof

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Embodiment

[0048] Collection and processing of samples: the present invention collected stool samples from subjects including patients with bipolar disorder (n=62) and healthy controls (n=60). Among them, in the present invention, the patients with bipolar disorder included in the group are inpatients and / or outpatients who meet the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR). At the same time meet the following inclusion criteria: 1) have not taken drugs or other psychiatric drugs for at least 3 months; 2) have no obvious suicidal thoughts or previous suicide attempts; 3) have no comorbidity with other mental disorders. Healthy subjects were recruited from the local community without any mental disorders and family history of mental illness. The two groups were matched for age, sex, and body mass index. Exclusion criteria for all subjects included: 1) chronic infection, serious systemic disease (such as diabetes), and autoimmune disease;...

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Abstract

The invention discloses bipolar affective disorder biomarkers based on enteric microorganism and screening and application thereof. The biomarkers includes six types of: 1) Ruminococcus_gnavus; 2) Eubacterium_hallii; 3) Alistipes_onderdonkii; 4) Faecalibacterium_prausnitzii; 5) Prevotella_stercorea; 6) Bacteroidales_bacterium_ph8. In the six biomarkers, the Ruminococcus_gnavus is increased in relative abundance in the bipolar affective disorder patient group, whereas the rest five biomarkers are decreased in relative abundances. The invention also discloses an application of the biomarkers asa detection target point or detection target in preparation of a detection kit, and an application of the biomarkers in the drugs for screening, treating and / or preventing the bipolar affective disorder as target points.

Description

technical field [0001] The present invention relates to bipolar disorder biomarkers based on gut microbes and their screening applications. Background technique [0002] Bipolar affective disorder is a group of severe and recurrent chronic mental illnesses, with a global incidence of about 2-3%. The age of onset is mainly concentrated in late adolescence or early adulthood, and it is the fourth leading cause of disability among young people worldwide. . Alternating or mixed episodes of depression, mania, or hypomania are the main clinical features, including bipolar disorder type I (at least one manic episode, no psychosis or major depressive episode) and bipolar disorder type II ( Patients have at least one hypomanic episode and at least one major depressive episode) and the subthreshold form, which manifests as dysfunction in sensory perception, emotional processing, and cognition. Residual mood symptoms often persist even after treatment, with approximately 37% of patie...

Claims

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Application Information

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IPC IPC(8): G16H50/30G16B30/10G16B40/00G06K9/62
CPCG16H50/30G16B30/10G16B40/00G06F18/24323Y02A90/10
Inventor 胡少华张佩芬来建波蒋佳俊许毅奚彩曦杜彦莉吴玲玲路静牟婷婷
Owner ZHEJIANG UNIV
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