Pharmaceutical forms of diazabicyclooctane derivatives and process for producing the same

A technology of drugs and compounds, applied in the direction of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc.

Pending Publication Date: 2020-07-24
MEIJI SEIKA KAISHA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Although other crystalline forms have been previously characterized, a large-scale manufact...

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  • Pharmaceutical forms of diazabicyclooctane derivatives and process for producing the same
  • Pharmaceutical forms of diazabicyclooctane derivatives and process for producing the same
  • Pharmaceutical forms of diazabicyclooctane derivatives and process for producing the same

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Embodiment Construction

[0026] In the following description, certain specific details are set forth in order to provide a thorough understanding of various embodiments of the invention. However, it will be understood by those skilled in the art that the present invention may be practiced without these details. Throughout the specification and claims, the word "comprises" and variations thereof should be interpreted in an open, inclusive sense (ie, "including but not limited to") unless the context requires otherwise.

[0027] Reference throughout this specification to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment of the present invention. Thus, appearances of the phrases "in one embodiment" or "in an embodiment" in various places throughout the specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures or ...

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Abstract

The present invention relates to a pharmaceutical composition and a lyophilisate of a diazabicyclooctane derivative represented by Compound I, a process for producing the same and methods for using the same.

Description

Background technique [0001] Penicillins and cephalosporins are widely and commonly used β-lactam antibiotics in clinic. However, acquired resistance to β-lactam antibiotics by various pathogens has a damaging effect on maintaining effective treatment of bacterial infections. The most important known mechanism associated with the acquisition of bacterial resistance is the production of class A, C and D beta-lactamases with a serine residue in the active center. These enzymes break down β-lactam antibiotics, resulting in loss of antimicrobial activity. Class A β-lactamases preferentially hydrolyze penicillins, whereas class C β-lactamases have substrate characteristics that facilitate the hydrolysis of cephalosporins. [0002] Commercially available β-lactamase inhibitors (e.g., clavulanic acid, sulbactam, and tazobactam) are known, and these inhibitors are mainly effective against class A β-lactamase producing bacteria, And it is used as a mixture with the penicillin antibio...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K47/26A61K31/439
CPCA61K9/19A61K31/439A61K31/437A61K47/26Y02A50/30A61P31/04
Inventor 杨可伟
Owner MEIJI SEIKA KAISHA LTD
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