9 results about "Cyclooctanes" patented technology

The invention discloses 4, 5-bis (fluorine gem dinitro)-1, 2, 3-triazole and a preparation method thereof, and the preparation method specifically comprises the following steps: step 1, adding 4, 5-bis (fluorine gem dinitro)-1, 2, 3-triazole potassium salt, 1-chloromethyl-4-fluoro-1, 4-diazotized bicyclic 2.2. 2 octane bis (tetrafluoroborate) salt and a reaction solvent into a reactor, and stirring until the materials are completely dissolved; 2, after dissolving is completed, reacting at room temperature; and 3, after the reaction is finished, spin-drying the solvent to obtain a solid, dissolving the solid by using an organic solvent, filtering, and concentrating to obtain a colorless liquid 4, 5-bis (fluorine gem dinitro)-1, 2, 3-triazole. The calculated density of the 4, 5-bis (fluorine gem dinitro)-1, 2, 3-triazole is large, the density of the 4, 5-bis (fluorine gem dinitro)-1, 2, 3-triazole is 2.01 g / cm < 3 >, and the theoretical density of 5-amino-3-nitro-1, 2, 4-triazole and the theoretical density of 3, 5-dinitro-1, 2, 4-triazole compounds in comparison files are 1.82 g / cm < 3 > and 1.83 g / cm and are improved by 10.4% and 9.8%.

The application belongs to the technical field of biological medicine, and relates to construction and application of a kind of nano oxygen delivery system based on internal peroxide. The application designs and synthesizes a kind of nano drug which can be used as a molecular oxygen delivery agent. In the nano drug, active molecules are composed of internal peroxide compound and 1,4-diazabicyclo[2.2.2]octane (DABCO), and the two molecules are constructed on gold nanorods to improve water solubility, biocompatibility and targeting of the active molecules. Finally, the active molecule modified gold nanorods obtained by the application can be used to relieve the damage of tissues and organs caused by hypoxia.

This paper describes a class of dyes containing 1,4-diazabicyclo[2.2.2]octane, their preparation methods, and applications, belonging to the fields of optical diagnostics and biomedicine. The dye comprises the dye molecule and 1,4-diazabicyclo[2.2.2]octane covalently coupled to the dye. 1,4-diazabicyclo[2.2.2]octane directly quenches singlet oxygen generated by the dye, affecting the triplet state of the dye, thereby improving its anti-bleaching ability and photostability, and reducing phototoxicity during fluorescence imaging. Furthermore, the introduction of 1,4-diazabicyclo[2.2.2]octane significantly improves the brightness of the dye, inhibits photoscintillation, and enhances its water solubility. Its protonation characteristic enhances the dye's mitochondrial targeting ability. These compounds, by reducing singlet oxygen and enhancing the local photothermal and reactive oxygen species production in mitochondria, induce potent cell necrosis, apoptosis, and immunogenic cell death, comprehensively improving anticancer efficacy. These compounds exhibit excellent photostability and low skin toxicity, showing broad application prospects.

The invention relates to a preparation method of bicyclo [2.2. 2] octane-2, 3, 5, 6-tetracarboxylic acid, and belongs to the technical field of preparation methods of fine chemicals. The preparation method comprises the following steps: S1, carrying out salt forming reaction on bicyclo [2.2. 2] octyl-7-ene-2, 3, 5, 6-tetracarboxylic dianhydride and alkali in a water system; s2, carrying out hydrogenation reduction reaction under the catalytic action; and S3, carrying out acidification reaction and post-treatment to obtain a bicyclo [2.2. 2] octane-2, 3, 5, 6-tetracarboxylic acid product. The preparation method provided by the invention has the advantages of simple production process, less production time, no over-high requirements on hydrogenation temperature and pressure, and good salt solution stability of the product; the yield, color and purity of the bicyclo [2.2. 2] octane-2, 3, 5, 6-tetracarboxylic acid are improved, the application requirements of high-end transparent polyimide materials are met, and the method is suitable for industrial application.

The invention belongs to the technical field of flame retardants, and particularly relates to a preparation method of a high-strength water-resistant halogen-free flame retardant, the prepared halogen-free flame retardant and application of the high-strength water-resistant halogen-free flame retardant. Phosphorus oxychloride and hydroquinone react to introduce phosphorus into reactants to obtain hydroquinone phosphoryl chloride; the preparation method comprises the following steps: reacting 2, 6, 7-trioxa-1-phosphoric acid bicyclo [2.2. 2] octane-4-yl methanol with a hydroxyl group of pentaerythritol, and introducing a bicyclic cage into a reactant by reacting halogen of phosphorus oxychloride with the hydroxyl group of pentaerythritol to obtain 2, 6, 7-trioxa-1-phosphoric acid bicyclo [2.2. 2] octane-4-yl methanol; finally, the halogen group of hydroquinone phosphoryl chloride and the hydroxyl group of 2, 6, 7-trioxa-1-phosphoric acid bicyclo [2.2. 2] octane-4-yl methanol are subjected to nucleophilic substitution, and redundant halogen and the amino group of 4, 4 '-diaminodiphenylmethane and 1, 6-hexamethylenediamine are subjected to an amination reaction to generate the high-strength water-resistant halogen-free flame retardant with a cross-linked structure, so that the stability and consistency of the material are improved, and the flame retardant property is improved. The flame retardant shows excellent mechanical strength, so that the flame retardant has longer service life in a severe environment.

The invention discloses an alternating polymer containing a bipyridine coordination group and a preparation method and application thereof, the alternating polymer containing the bipyridine coordination group comprises a hydrophilic flexible chain segment and a functional chain segment, and the number-average molecular weight of the alternating polymer is 1.5 * 10 < 4 >-7.5 * 10 < 4 > g / mol. The molecular weight distribution of the alternating polymer is 1.0 to 1.5. The preparation method comprises the following steps: carrying out polymerization reaction on polyethylene glycol dipropiolate and 4, 4 '-bis (hydroxymethyl)-2, 2'-dipyridyl under the action of a catalyst 1, 4-diazabicyclo [2.2. 2] octane, so as to obtain the alternating polymer containing the dipyridyl coordination group. The alternating polymer containing the bipyridine coordination group provided by the invention simultaneously comprises a hydrophilic flexible chain segment and a functional chain segment, so that dendritic crystal growth can be remarkably inhibited, and the cycling stability and electrochemical performance of an electrode are improved.

This invention discloses a porous framework material based on a carborane framework, its preparation method, and its applications. The porous framework material is obtained by coordinating a metal ion M with a carboxylated carborane to form a two-dimensional planar structure, and then using an organic nitrogen-containing ligand as a pillar to form a three-dimensional framework structure; the metal ion M is selected from Cu. 2+ Zn 2+ Ni 2+ Co 2+ At least one of the following: the carboxycarborane is selected from at least one of para-carboxycarborane and meta-carboxycarborane; the organic nitrogen-containing ligand is selected from at least one of 1,4-diazabicyclo[2.2.2]octane, pyrazine, 4,4'-bipyridine, and piperazine. Preparation method: The salt containing metal ion M, the carboxycarborane, and the organic nitrogen-containing ligand are reacted in a solvent at 50-100℃ to obtain a solid product; the solid product is placed in methanol for one or more solvent exchanges to remove solvent molecules, and then vacuum degassing and activation are performed to remove methanol molecules from the channels to obtain a porous framework material.

The application belongs to the technical field of membranes, and relates to a preparation method of an acid and alkali resistant anion exchange membrane with high anion flux, comprising the following steps: dissolving polysulfone in an organic solvent, adding polyformaldehyde and trimethylchlorosilane, fully mixing and sealing and stirring for 1-120 min, then adding tin chloride drop by drop, fully mixing and sealing and stirring, reacting for 1-10 d at 10-50 DEG C, pouring into an alcohol solvent, and obtaining chlorinated polysulfone material; dissolving the chlorinated polysulfone material in N,N-dimethylformamide, adding 1,4-diazido bicyclo[2,2,2]octane, fully mixing and sealing and stirring, reacting, ultrasonic defoaming, obtaining a casting solution, scraping into a film, vacuum drying, and obtaining the anion exchange membrane. The preparation process is simple and easy to operate, and the prepared anion exchange membrane has good acid and alkali resistance, high ion flux and impact mechanical properties.

The invention belongs to the technical field of steroid drug molecules, and relates to an estrone purification method, which comprises the following steps: adding 1, 4-diazabicyclo [2.2. 2] octane into a solution containing an estrone crude product and a first solvent to obtain a precipitate, dissolving the precipitate in a second solvent, adjusting to be alkaline, filtering, collecting filtrate, adjusting the pH value of the filtrate to be less than or equal to 3, and filtering to obtain the estrone purification product. And extracting with a third solvent to obtain an organic phase, cooling, crystallizing, carrying out suction filtration, and drying to obtain refined estrone. According to the method, the problem of removal of methylation rearrangement impurities generated in the existing preparation technology of the estrone is solved, the methylation rearrangement impurities can be purified from 0.7%-1.5% to less than or equal to 0.10% at a time, the purity of the finally obtained estrone is greater than or equal to 99.8%, and the yield is stable. The method disclosed by the invention is green and environment-friendly, low in cost, less in material loss, good in purification effect and stable in process, and has extremely high industrial application value.