24 results about "Cyclooctanes" patented technology

The invention provides a preparation method of ethylene carbonate and ethylene sulfate, which comprises the following steps: 1) by taking vinylethylene carbonate as a raw material, carrying out oxidation reaction with an oxidant to obtain epoxy ethylene carbonate as shown in a formula I; and 2) carrying out heating reaction on the epoxy ethylene carbonate as shown in the formula I obtained in the step 1) and sulfamic acid in an acidic solvent to obtain ethylene carbonate disulfate as shown in a formula II. The method avoids the problem of poor reaction selectivity caused by using butantetraol as a raw material in the prior art; according to the method disclosed by the invention, an intermediate butantetraol carbonate is not generated, so that the problem that the intermediate further reacts to generate a byproduct 2, 4, 7-trioxa-3-oxy-bicyclo [3.3. 0] octane does not exist; in addition, when the final product sulfate is synthesized, mild and non-irritant sulfamic acid is used, and the method has the advantages of being clean, green and environmentally friendly.

The invention discloses 4, 5-bis (fluorine gem dinitro)-1, 2, 3-triazole and a preparation method thereof, and the preparation method specifically comprises the following steps: step 1, adding 4, 5-bis (fluorine gem dinitro)-1, 2, 3-triazole potassium salt, 1-chloromethyl-4-fluoro-1, 4-diazotized bicyclic 2.2. 2 octane bis (tetrafluoroborate) salt and a reaction solvent into a reactor, and stirring until the materials are completely dissolved; 2, after dissolving is completed, reacting at room temperature; and 3, after the reaction is finished, spin-drying the solvent to obtain a solid, dissolving the solid by using an organic solvent, filtering, and concentrating to obtain a colorless liquid 4, 5-bis (fluorine gem dinitro)-1, 2, 3-triazole. The calculated density of the 4, 5-bis (fluorine gem dinitro)-1, 2, 3-triazole is large, the density of the 4, 5-bis (fluorine gem dinitro)-1, 2, 3-triazole is 2.01 g / cm < 3 >, and the theoretical density of 5-amino-3-nitro-1, 2, 4-triazole and the theoretical density of 3, 5-dinitro-1, 2, 4-triazole compounds in comparison files are 1.82 g / cm < 3 > and 1.83 g / cm and are improved by 10.4% and 9.8%.

The present invention belongs to the technical field of preparation of oxadiazole derivatives. The present invention provides a method for preparing 2-amino-1,3,4-oxadiazole derivatives by electrocatalysis, comprising the following steps: adding 0.2mmol of benzoylhydrazide compounds, 0.4mmol of tetrabutylammonium iodide, 0.4mmol of 1,4-diazabicyclo[2.2.2]octane, 0.4mmol of sodium bicarbonate, and 6mL of acetonitrile to an electrolytic cell; then adding 0.3mmol of phenyl isothiocyanate compounds dropwise; reacting under a DC constant current between an electrode anode and an electrode cathode. The present invention adopts electrocatalysis with benzoylhydrazide and phenyl isothiocyanate as reaction substrates, acetonitrile and other cheap and less toxic reagents as solvents, and passing current to replace the oxidant in conventional reactions, thereby synthesizing oxadiazole compounds under mild and green conditions.

A blonanserin oral soluble film composition, comprising an active drug, a film-forming material, and a plasticizer. The active drug is one or more of 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocyclooctapyridine as represented by formula I and a pharmaceutically acceptable salt, a hydrate, and a solvate thereof. The blonanserin oral soluble film composition has the advantages of thin thickness, good taste, stable properties, good dissolution rate, instant dissolution in the oral cavity without drinking water, particular suitability for patients suffering from dysphagia, no gravel feeling after dissolution in the oral cavity, and fast oral absorption rate. The composition also has a uniform appearance, good flexibility, a simple process, no sedimentation in the process of film liquid preparation, content uniformity meeting the requirements, a high drug loading capacity, and good marketing prospects.

The application discloses a method for photocatalytically preparing 3-aminoquinoxalin-2(1 H )-ketone compounds, and belongs to the field of organic synthesis. The application comprises the following steps: quinoxalin-2(1 H )-ketone compounds, fatty amine compounds, a photocatalyst mpg-C3N4 (mesoporous graphite phase carbon nitride) and an alkali DABCO (1,4-diazabicyclo (2.2.2) octane) are added into an organic solvent and uniformly mixed; the reaction is carried out under the irradiation of light in an oxygen atmosphere; and after the reaction is completed, the 3-aminoquinoxalin-2(1 H )-ketone product is obtained through treatment and separation. The application uses DABCO as an alkali and an electron transfer agent, and adopts mpg-C3N4 to photocatalytically prepare 3-aminoquinoxalin-2(1 H )-ketone compounds under the auxiliary condition of DABCO, and it is concluded from DABCO quenching experiments and cyclic voltammetry experiments that there is a single electron transfer relationship between them; and the application has the advantages of mild reaction conditions, simple operation and the ability to synthesize 3-aminoquinoxalin-2(1 H )-ketone compounds in one step.

The invention belongs to the technical field of medicine detection methods, and particularly relates to a quantitative detection method of a drug for treating infectious encephalitis by targeting Hsp90 alpha in a biological sample. According to the present invention, the Hsp90 alpha-targeting drug for treating infectious encephalitis is 2-((4-hydroxybicyclo [2.2. 2] octane-1-yl) amino)-4-(3, 6, 6-trimethyl-4-oxo-4, 5, 6, 7-tetrahydro-1H-indazole-1-yl) benzamide, and the drug is subjected to quantitative analysis by using a liquid chromatography-mass spectrometry method, the detection method is strong in specificity and high in accuracy, the in-vivo and in-vitro absorption, distribution, metabolism and excretion conditions of the medicine and the in-vivo and in-vitro targeted treatment effect of the medicine are determined by measuring the content of the medicine in a biological sample, and the method is beneficial to promoting medicine development, determining the pharmacokinetic condition of the medicine and assisting medicine toxicology evaluation.

The invention provides a liquid epoxy molding compound with a low thermal expansion coefficient and a preparation method thereof. The epoxy molding compound comprises the following components in percentage by weight: 4-10% of epoxy resin, 80-90% of modified inorganic silicon filler, 1-10% of a curing agent and 0.1-1% of an accelerant, the content sum of the components is 100%, and the modified inorganic silicon filler is prepared by modifying inorganic silicon with gamma-glycidoxypropyltrimethoxysilane and then reacting with aminated dibenzocyclooctane. According to the preparation method disclosed by the invention, surface modification is carried out on the inorganic silicon filler through aminated dibenzocyclooctane groups, and dibenzocyclooctane is subjected to conformation transformation from a ship form to a chair form in a heating process, so that the thermal expansion coefficient of a system is actively regulated and controlled; in addition, the amino group of the aminated dibenzocyclooctane group and the epoxy resin matrix are subjected to covalent reaction, and can be fully dispersed and participated in the whole molecular cross-linked network; due to the synergistic effect of the thermal expansion coefficient of the active regulation and control system and the reduction of interface defects, the thermal expansion coefficient of the liquid epoxy molding compound in the molding stage is remarkably reduced, and the warping problem of a plastic package body is greatly solved.

The invention belongs to the technical field of organic synthesis methodology, and particularly relates to a photoinduced beta-cyano sulfone compound synthesis method based on a triarylamine electron donor acceptor compound and application of the photoinduced beta-cyano sulfone compound. According to the method, a substituted sulfonium salt serves as an electron acceptor, triarylamine serves as an electron donor to form an EDA compound, and under the action of visible light, the EDA compound is synthesized into a beta-cyano sulfone compound based on the triarylamine electron donor acceptor compound. The method comprises the following steps: by taking substituted cyanohydrin as a raw material and 4-diazabicyclo [2.2. 2] octane di (sulfur dioxide) adduct [(DABCO). (SO2) 2] as a sulfur source, adding an organic solvent, reacting in an inert gas at a certain temperature, and realizing a bifunctionalization process of olefin through far-end functional group migration, thereby obtaining the beta-cyano sulfone compound. The method does not need harsh reaction conditions, the reaction can be completed in one step, the reaction conditions are mild, and the method is green and environment-friendly. The beta-cyano sulfone compound and the derivative thereof prepared by the method are expected to be applied to the research and development fields of anti-cancer, antiviral and antibacterial medicines and the like.

The application belongs to the technical field of biological medicine, and relates to construction and application of a kind of nano oxygen delivery system based on internal peroxide. The application designs and synthesizes a kind of nano drug which can be used as a molecular oxygen delivery agent. In the nano drug, active molecules are composed of internal peroxide compound and 1,4-diazabicyclo[2.2.2]octane (DABCO), and the two molecules are constructed on gold nanorods to improve water solubility, biocompatibility and targeting of the active molecules. Finally, the active molecule modified gold nanorods obtained by the application can be used to relieve the damage of tissues and organs caused by hypoxia.

The invention discloses a bicyclo [4.1. 1] octane azafluorene derivative with a structural formula shown as a formula I. A preparation method comprises the following steps: reacting a 2-(2-(2-hydroxybenzylidene)-2, 3-dihydro-1H-indenyl-1-methylene) malononitrile derivative for 0.5-6 hours in the presence of an organic or inorganic base catalyst and a DMF (Dimethyl Formamide) solvent at the temperature of 40-150 DEG C, adding distilled water after the reaction is finished, and reacting for 0.5-6 hours at the temperature of 40-150 DEG C to obtain the bicyclo [4.1. 1] octane azafluorene derivative with the structural formula shown as the formula I. The invention further discloses a preparation method of the bicyclo [4.1. 1] octane azafluorene derivative. Extracting with ethyl acetate, drying with anhydrous sodium sulfate, filtering, concentrating, and carrying out column chromatography separation. The invention provides a simple, efficient and convenient preparation method of the bicyclo [4.1. 1] octane azafluorene derivative, and the preparation method has the advantages of high efficiency, convenience, low cost and the like, and has a good application prospect. The derivative can be applied as an organic catalyst or an organic photoelectric material, a fluorescent material and the like.

This paper describes a class of dyes containing 1,4-diazabicyclo[2.2.2]octane, their preparation methods, and applications, belonging to the fields of optical diagnostics and biomedicine. The dye comprises the dye molecule and 1,4-diazabicyclo[2.2.2]octane covalently coupled to the dye. 1,4-diazabicyclo[2.2.2]octane directly quenches singlet oxygen generated by the dye, affecting the triplet state of the dye, thereby improving its anti-bleaching ability and photostability, and reducing phototoxicity during fluorescence imaging. Furthermore, the introduction of 1,4-diazabicyclo[2.2.2]octane significantly improves the brightness of the dye, inhibits photoscintillation, and enhances its water solubility. Its protonation characteristic enhances the dye's mitochondrial targeting ability. These compounds, by reducing singlet oxygen and enhancing the local photothermal and reactive oxygen species production in mitochondria, induce potent cell necrosis, apoptosis, and immunogenic cell death, comprehensively improving anticancer efficacy. These compounds exhibit excellent photostability and low skin toxicity, showing broad application prospects.

The application provides a liquid epoxy plastic sealing material with low thermal expansion coefficient and a preparation method thereof. The epoxy plastic sealing material comprises, by weight fraction, 4-10% of epoxy resin, 80-90% of modified inorganic silicon filler, 1-10% of curing agent and 0.1-1% of accelerator, wherein the sum of the content of each component is 100%, and the modified inorganic silicon filler is prepared by modifying inorganic silicon with gamma-glycidoxypropyltrimethoxysilane first and then reacting with aminated dibenzocyclooctane. In the application, the inorganic silicon filler is surface modified by aminated dibenzocyclooctane group, the dibenzocyclooctane group undergoes a conformational transition from boat form to chair form in the heating process, thereby actively regulating the thermal expansion coefficient of the system; in addition, the amino group of the aminated dibenzocyclooctane group covalently reacts with the epoxy resin matrix, can be fully dispersed and involved in the whole molecular crosslinking network; due to the synergistic effect of actively regulating the thermal expansion coefficient of the system and reducing the interface defects, the thermal expansion coefficient of the liquid epoxy plastic sealing material in the forming stage is significantly reduced, and the warping problem of the plastic sealing body is greatly improved.

The invention discloses a column layer ultra-microporous metal organic framework material and a preparation method and application thereof in gas separation, the chemical formula of the metal organic framework material is [Co3 (BDC-CH3) 3 (DABCO)] n, BDC-CH3 is a first organic ligand 2-methyl-1, 4-phthalic acid, and DABCO is a second organic ligand 1, 4-diazabicyclo [2.2. 2] octane. The pore structure of the column layer ultramicropore metal organic framework material is a triangular pore channel, the column layer ultramicropore metal organic framework material has high adsorption energy and high adsorption capacity for acetylene, regeneration can be achieved, acetylene can be preferentially adsorbed from acetylene / carbon dioxide mixed gas, the adsorption selectivity is relatively high, and therefore efficient separation of acetylene and carbon dioxide is achieved.

The invention relates to the field of sodium-ion batteries, in particular to a sodium-ion battery electrolyte suitable for a low-temperature environment and a preparation method of the sodium-ion battery electrolyte. The sodium-ion battery electrolyte is composed of a solvent, sodium salt and an additive. 1, 4-diazabicyclo octane in the solvent has the characteristics of high alkalinity and lone pair electrons, is preferentially combined with H < + >, inhibits electrolyte hydrolysis to generate HF, and assists in stabilizing an SEI film; the nanoscale Al2O3 in the additive can react with a small amount of generated HF to generate stable AlF3, so that the chain reaction of electrode corrosion by HF and generation of more HF is blocked, and the electrode structure is protected; the additive composition can construct an anti-decomposition-corrosion-stable SEI system, gas expansion and side reaction gas production are reduced by 90% or above, and explosion prevention of the electrolyte is achieved through a dual mechanism of free radical capture and flash point lifting.

The invention relates to a preparation method of bicyclo [2.2. 2] octane-2, 3, 5, 6-tetracarboxylic acid, and belongs to the technical field of preparation methods of fine chemicals. The preparation method comprises the following steps: S1, carrying out salt forming reaction on bicyclo [2.2. 2] octyl-7-ene-2, 3, 5, 6-tetracarboxylic dianhydride and alkali in a water system; s2, carrying out hydrogenation reduction reaction under the catalytic action; and S3, carrying out acidification reaction and post-treatment to obtain a bicyclo [2.2. 2] octane-2, 3, 5, 6-tetracarboxylic acid product. The preparation method provided by the invention has the advantages of simple production process, less production time, no over-high requirements on hydrogenation temperature and pressure, and good salt solution stability of the product; the yield, color and purity of the bicyclo [2.2. 2] octane-2, 3, 5, 6-tetracarboxylic acid are improved, the application requirements of high-end transparent polyimide materials are met, and the method is suitable for industrial application.

The invention belongs to the technical field of flame retardants, and particularly relates to a preparation method of a high-strength water-resistant halogen-free flame retardant, the prepared halogen-free flame retardant and application of the high-strength water-resistant halogen-free flame retardant. Phosphorus oxychloride and hydroquinone react to introduce phosphorus into reactants to obtain hydroquinone phosphoryl chloride; the preparation method comprises the following steps: reacting 2, 6, 7-trioxa-1-phosphoric acid bicyclo [2.2. 2] octane-4-yl methanol with a hydroxyl group of pentaerythritol, and introducing a bicyclic cage into a reactant by reacting halogen of phosphorus oxychloride with the hydroxyl group of pentaerythritol to obtain 2, 6, 7-trioxa-1-phosphoric acid bicyclo [2.2. 2] octane-4-yl methanol; finally, the halogen group of hydroquinone phosphoryl chloride and the hydroxyl group of 2, 6, 7-trioxa-1-phosphoric acid bicyclo [2.2. 2] octane-4-yl methanol are subjected to nucleophilic substitution, and redundant halogen and the amino group of 4, 4 '-diaminodiphenylmethane and 1, 6-hexamethylenediamine are subjected to an amination reaction to generate the high-strength water-resistant halogen-free flame retardant with a cross-linked structure, so that the stability and consistency of the material are improved, and the flame retardant property is improved. The flame retardant shows excellent mechanical strength, so that the flame retardant has longer service life in a severe environment.

The invention discloses a singlet oxygen-triplet oxygen synergistic delivery carrier and application thereof, and belongs to the technical field of biological medicines. The carrier is formed by taking an internal peroxide structure as a core and taking L-proline and 1, 4-diazabicyclo [2.2. 2] octane (DABCO) as singlet oxygen physical quenching groups. An internal peroxide structure is subjected to a reverse cyclization reaction at a certain temperature to release toxic singlet oxygen, and meanwhile, a quenching group quenches part of singlet oxygen to generate triplet oxygen, so that the molecule has the effects of relieving tumor hypoxia and killing tumors at the same time. An in-vitro test proves that the molecule provided by the invention releases triplet oxygen while releasing singlet oxygen, so that synergistic delivery of singlet oxygen-triplet oxygen is realized. According to the invention, establishment of the singlet oxygen-triplet oxygen synergistic delivery carrier is successfully realized, and the singlet oxygen-triplet oxygen synergistic delivery carrier can be used for relieving tumor hypoxia and improving the singlet oxygen killing effect, and has a wide application prospect.

The invention relates to a bicyclooctane-1, 2, 4-oxadiazole derivative as well as a preparation method and application thereof, and belongs to the technical field of pesticides. The structure of the bicyclooctane-1, 2, 4-oxadiazole derivative is as shown in a formula I in the specification, the invention also provides a method for preparing the compound as shown in the formula I and application of the compound. The dicyclooctane-1, 2, 4-oxadiazole derivative provided by the invention has a remarkable inhibition effect on puccinia puccinia under the condition of low application amount, and has an inhibition rate of 80% or more on puccinia puccinia when the low concentration is 1.6 mg / L, and the inhibition effect is obviously superior to that of triflumioxazole. Meanwhile, the dicyclooctane-1, 2, 4-oxadiazole derivative provided by the invention also has an outstanding effect in prevention and treatment of the root-knot nematode, and the selectivity of pesticides in the field of prevention and treatment of the root-knot nematode is widened.

The invention discloses an alternating polymer containing a bipyridine coordination group and a preparation method and application thereof, the alternating polymer containing the bipyridine coordination group comprises a hydrophilic flexible chain segment and a functional chain segment, and the number-average molecular weight of the alternating polymer is 1.5 * 10 < 4 >-7.5 * 10 < 4 > g / mol. The molecular weight distribution of the alternating polymer is 1.0 to 1.5. The preparation method comprises the following steps: carrying out polymerization reaction on polyethylene glycol dipropiolate and 4, 4 '-bis (hydroxymethyl)-2, 2'-dipyridyl under the action of a catalyst 1, 4-diazabicyclo [2.2. 2] octane, so as to obtain the alternating polymer containing the dipyridyl coordination group. The alternating polymer containing the bipyridine coordination group provided by the invention simultaneously comprises a hydrophilic flexible chain segment and a functional chain segment, so that dendritic crystal growth can be remarkably inhibited, and the cycling stability and electrochemical performance of an electrode are improved.

This invention discloses a porous framework material based on a carborane framework, its preparation method, and its applications. The porous framework material is obtained by coordinating a metal ion M with a carboxylated carborane to form a two-dimensional planar structure, and then using an organic nitrogen-containing ligand as a pillar to form a three-dimensional framework structure; the metal ion M is selected from Cu. 2+ Zn 2+ Ni 2+ Co 2+ At least one of the following: the carboxycarborane is selected from at least one of para-carboxycarborane and meta-carboxycarborane; the organic nitrogen-containing ligand is selected from at least one of 1,4-diazabicyclo[2.2.2]octane, pyrazine, 4,4'-bipyridine, and piperazine. Preparation method: The salt containing metal ion M, the carboxycarborane, and the organic nitrogen-containing ligand are reacted in a solvent at 50-100℃ to obtain a solid product; the solid product is placed in methanol for one or more solvent exchanges to remove solvent molecules, and then vacuum degassing and activation are performed to remove methanol molecules from the channels to obtain a porous framework material.

The invention discloses polyfunctional group four-season ammonium ionic liquid and a preparation method thereof. According to the invention, 1, 4-diazido-bicyclo [2, 2, 2] octane, glycol, phosphorus trichloride or phosphorus tribromide, alkyl sultone and a sulfonic acid derivative are used as raw materials to prepare the polyfunctional group four-season ammonium ionic liquid; the method comprises the following steps: preparing dibromo (chloro) glycol by taking glycol, phosphorus trichloride or phosphorus tribromide as raw materials; the preparation method comprises the following steps: reacting 1, 4-diazido-bicyclo [2, 2, 2] octane with dibromo (chloro) glycol to prepare a tetranuclear quaternary ammonium intermediate; reacting the tetranuclear quaternary ammonium intermediate with alkyl sultone to prepare tetranuclear quaternary ammonium sulfonic acid inner salt; the polyfunctional group four-season ammonium ionic liquid is prepared by taking tetranuclear quaternary ammonium sulfonic acid inner salt and a sulfonic acid derivative as raw materials. The invention provides a new scheme for preparing the multifunctional ionic liquid.

The application belongs to the technical field of membranes, and relates to a preparation method of an acid and alkali resistant anion exchange membrane with high anion flux, comprising the following steps: dissolving polysulfone in an organic solvent, adding polyformaldehyde and trimethylchlorosilane, fully mixing and sealing and stirring for 1-120 min, then adding tin chloride drop by drop, fully mixing and sealing and stirring, reacting for 1-10 d at 10-50 DEG C, pouring into an alcohol solvent, and obtaining chlorinated polysulfone material; dissolving the chlorinated polysulfone material in N,N-dimethylformamide, adding 1,4-diazido bicyclo[2,2,2]octane, fully mixing and sealing and stirring, reacting, ultrasonic defoaming, obtaining a casting solution, scraping into a film, vacuum drying, and obtaining the anion exchange membrane. The preparation process is simple and easy to operate, and the prepared anion exchange membrane has good acid and alkali resistance, high ion flux and impact mechanical properties.

The invention belongs to the technical field of steroid drug molecules, and relates to an estrone purification method, which comprises the following steps: adding 1, 4-diazabicyclo [2.2. 2] octane into a solution containing an estrone crude product and a first solvent to obtain a precipitate, dissolving the precipitate in a second solvent, adjusting to be alkaline, filtering, collecting filtrate, adjusting the pH value of the filtrate to be less than or equal to 3, and filtering to obtain the estrone purification product. And extracting with a third solvent to obtain an organic phase, cooling, crystallizing, carrying out suction filtration, and drying to obtain refined estrone. According to the method, the problem of removal of methylation rearrangement impurities generated in the existing preparation technology of the estrone is solved, the methylation rearrangement impurities can be purified from 0.7%-1.5% to less than or equal to 0.10% at a time, the purity of the finally obtained estrone is greater than or equal to 99.8%, and the yield is stable. The method disclosed by the invention is green and environment-friendly, low in cost, less in material loss, good in purification effect and stable in process, and has extremely high industrial application value.

The present invention relates to the field of polypeptide conjugates, more in particular to conjugates comprising a polypeptide, a nucleic acid and a linker, wherein the conjugation involves a click chemistry between an organic azide and dibenzocyclooctine (DBCO) derivatives. The invention relates as well to methods to obtain such conjugates, as well as to their use in the treatment of a neurological disease, a brain disease, or cancer.