13 results about "Optical diagnostics" patented technology

This invention discloses a method for identifying the pulsation frequency of a flame under the influence of an acoustic field. The method is validated using a back-diffusion flame as an example, identifying the pulsation frequency of the back-diffusion flame under different acoustic parameters. The method involves acquiring continuously changing flame images under different operating conditions using a non-invasive optical diagnostic system, binarizing the images to divide them into flame and non-flame regions, and calculating the overlap rate of each image relative to the first flame image. Analysis shows that the flame pulsation frequency can be determined by observing changes in the overlap rate. Experimental verification demonstrates that this method can accurately determine the flame pulsation frequency under different acoustic parameters.

This invention discloses a temperature- and pressure-controlled volumetric cartridge with replaceable windows, comprising an upper cover, a main window, and a lower cover. The main window has a viewing window and is detachably connected between the upper and lower covers. Several connecting screws are fixed to the edge of the lower cover, with one end of the connecting screw away from the lower cover passing through the edge of the upper cover. The upper cover and the connecting screws are slidably connected, and a locking nut is threaded onto one end of the connecting screw that extends out of the mounting plate. The main window is located between the upper and lower covers, and can be clamped and fixed between the upper and lower covers by tightening the locking nut. This invention adopts a replaceable three-section split design and is equipped with multiple sets of replaceable windows. A single volumetric cartridge can meet various diagnostic needs, significantly reducing the cost of spray optical diagnostic testing. Furthermore, the temperature and pressure inside the volumetric cartridge are adjustable, and the airflow is uniform and controllable, efficiently organizing the airflow movement within the cartridge and avoiding airflow dead zones.

The application provides a micro-fluidic burner for microscopic optical diagnosis experiment, and belongs to the technical field of online combustion diagnosis. The burner comprises a mounting assembly for fixing the micro-fluidic burner, a cavity assembly for connecting with an experimental gas path, a nozzle connected with the gas path in the cavity assembly for realizing ignition combustion, a nozzle fixing assembly for fixing the nozzle on the cavity assembly, and a light window for transmitting laser and weak scattering signals of optical diagnosis to observe combustion. The cavity assembly comprises a sealingly connected upper cavity and lower cavity. The micro-fluidic burner can ignite methane, acetylene, ethylene and other gas flames, has the characteristics of small volume and replaceable nozzle, realizes positioning and fitting of the combustion nozzle by adopting a conical surface structure, can replace combustion nozzles with different structures according to actual research needs, can be used for microscopic diagnosis in the optical aspect, and can be particularly applied to in-situ microscopic Raman spectrum diagnosis of combustion carbon deposition.

This paper describes a class of dyes containing 1,4-diazabicyclo[2.2.2]octane, their preparation methods, and applications, belonging to the fields of optical diagnostics and biomedicine. The dye comprises the dye molecule and 1,4-diazabicyclo[2.2.2]octane covalently coupled to the dye. 1,4-diazabicyclo[2.2.2]octane directly quenches singlet oxygen generated by the dye, affecting the triplet state of the dye, thereby improving its anti-bleaching ability and photostability, and reducing phototoxicity during fluorescence imaging. Furthermore, the introduction of 1,4-diazabicyclo[2.2.2]octane significantly improves the brightness of the dye, inhibits photoscintillation, and enhances its water solubility. Its protonation characteristic enhances the dye's mitochondrial targeting ability. These compounds, by reducing singlet oxygen and enhancing the local photothermal and reactive oxygen species production in mitochondria, induce potent cell necrosis, apoptosis, and immunogenic cell death, comprehensively improving anticancer efficacy. These compounds exhibit excellent photostability and low skin toxicity, showing broad application prospects.

This invention discloses a near-infrared II photothermal therapeutic agent, its preparation method, and its application, belonging to the field of optical diagnostics and treatment technology. To address the problems of insufficient light absorption, fluorescence quenching, and inadequate molecular structure optimization in existing photothermal therapeutic agents, this invention proposes a molecular design strategy of "central plane + peripheral twisting," developing a novel NIR-II photothermal therapeutic agent, 4TPE-TB, which is a near-infrared II photothermal therapeutic agent. This invention enhances the light absorption capacity of the near-infrared II photothermal therapeutic agent by strengthening the conjugation of the molecular core, and utilizes the peripheral twisted structure to suppress intermolecular stacking, significantly improving photothermal conversion efficiency and fluorescence performance, thereby achieving a comprehensive improvement in the therapeutic agent's performance.

This invention discloses a visible light bremsstrahlung diagnostic device and a method for measuring the electron density profile of fusion plasma. The visible light bremsstrahlung diagnostic device includes a vacuum chamber, an objective lens, an optical fiber, a spectrometer, and a spectral detector. The vacuum chamber is used to generate plasma and has an observation window. The objective lens, optical fiber, spectrometer, and spectral detector are sequentially connected to form an optical diagnostic system for observation. Accordingly, the front end of the objective lens faces the observation window, and the visible light bremsstrahlung of the plasma is observed through the observation window. The method for measuring the electron density profile of fusion plasma includes the following steps: S100 Measurement: Measuring the radiation of the plasma using the visible light bremsstrahlung diagnostic device; S200 Calculation: Calculating the plasma electron density profile using a formula. Compared with existing contact measurement methods, the visible light bremsstrahlung diagnostic device and the method for measuring the electron density profile of fusion plasma provide a non-contact, interference-free measurement method.

This invention belongs to the field of biomedical technology, specifically relating to a method for preparing a renal-clearable optical diagnostic probe-cell conjugate and its application. The invention involves fusing a renal-clearable optical diagnostic probe with a maleimide-modified polyethylene glycol chain, followed by incubation with Traut's-pretreated cells to obtain the renal-clearable optical diagnostic probe-cell conjugate. This method is simple, time-saving, and efficient, applicable to various renal-clearable optical diagnostic probes and cell types. Furthermore, this method has minimal impact on cell viability, disease targeting ability, and ability to cross physiological barriers. In addition, the renal-clearable optical diagnostic probe-cell conjugate constructed using this method can release renal-clearable fragments in the disease microenvironment, thereby enabling early diagnosis of various diseases through urine analysis, exhibiting high sensitivity and specificity.

The present invention relates to the field of optical imaging. More particularly, it relates to fluorescent probes targeting carbonic anhydrase nine (CA-IX) comprising near-infrared (NIR) dyes of the cyanine. The invention also relates to the methods for preparing these compounds, to pharmaceutical compositions and kits incorporating them and to methods of use them as optical diagnostic agents in imaging or therapy of diseases such as solid tumors with hypoxic tissues involving cells expressing CA-IX.

The invention provides a high-temperature and high-pressure endoscopic optical fiber sensor probe for an engine combustion chamber. The high-temperature and high-pressure endoscopic optical fiber sensor probe comprises a sensor ceramic substrate, a sapphire lens assembly, a metal sealing ring, a metal transition layer and a high-temperature quartz optical fiber, the sensor ceramic substrate is provided with a light path channel in a penetrating manner, the outer wall of the front end is provided with a section of fine thread, and an annular thick end face is arranged behind the fine thread; a metal sealing ring is embedded in the annular thick end face. The sapphire lens assembly is embedded in one end of the light path channel, and the outer wall of the sapphire lens assembly and the light path channel are welded and fixed through a metal transition layer. The high-temperature quartz optical fiber comprises an optical fiber input end and two output optical fibers which are welded with the optical fiber input end through an electric arc welding technology. The device is compact in overall structural design, high in environment resistance and suitable for real-time multi-parameter optical diagnosis and state monitoring of high-temperature and high-pressure combustion systems such as aero-engines and gas turbines.

The utility model relates to the technical field of high-voltage circuit breakers, and discloses a high-voltage circuit breaker arc extinguish chamber capable of observing electric arcs and a matched installation clamp, which comprise a moving arc contact, a static arc contact, a shell, a shell visual window, a nozzle and a nozzle visual window, the movable arc contact is fixedly connected with the nozzle, the static arc contact is fixed on the other side, the movable arc contact can be in contact with or away from the static arc contact, the nozzle visual window is a transparent part and is arranged on the nozzle, arc extinguishing gas is accelerated after flowing through the nozzle, arc extinguishing is helped, and the static arc contact, the movable arc contact and the nozzle are all arranged in the shell. The shell visual window is installed on the shell and used for observing the arc extinguishing condition of the spraying area from the outside of the shell through the nozzle visual window. And the capability of directly observing the arc form in the arc extinguish chamber from the outside is realized, so that the arc can be directly analyzed by utilizing an optical diagnosis technology in the operation process of the high-voltage circuit breaker.

The invention discloses a combustion heat release rate measuring device and method based on an ultrafast spectrum, and belongs to the technical field of combustion optical diagnosis. Comprising a femtosecond optical frequency comb, a collimator, a first beam splitter, a first transmission grating, a first lens, a flame sample, a displacement platform, a second lens, a second transmission grating, a first reflector, a second beam splitter, a spatial optical coupler, a dispersion optical fiber, a photoelectric detector, an oscilloscope and a computer, and a second reflecting mirror and a reference sample pool are arranged between the first beam splitter and the second beam splitter. The invention provides a high time resolution test means for high-frequency combustion oscillation.

Disclosed is a method and apparatus for determining one or more characteristics of a gas species in a system (e.g., an EUV lithographic system). The method and apparatus use optical diagnostics, in particular cavity ring-down spectroscopy (CRDS), to accurately quantify in-situ the gas species in the system. Also disclosed are various configurations of an optical system many of which allow simultaneous measurements of the gas species in different locations of the system.

This invention specifically discloses a method, system, device, and medium for behavioral intervention of children's visual and spinal health, relating to the field of children's health management service technology. The method comprises the following steps: S1. Based on a classification framework of posture, light, and distance, acquire children's sitting posture, environment, and spatial data in reading and writing scenarios; S2. Upload the collected data to a cloud server and compare it with preset standard data to calculate a multi-dimensional risk score and determine the overall risk level; S3. Generate a children's visual and spinal health behavioral optical diagnostic report including a measured data table, risk dimension charts, and risk interpretations; S4. Retrieve detailed plans from a pre-set intervention plan knowledge base according to the rectification plan code and output them synchronously; S5. Within a preset period after the intervention, generate a before-and-after comparison report and provide continuous optimization suggestions. This invention achieves seamless integration of assessment and intervention, effectively improving the accuracy, operability, and sustainability of children's reading and writing visual and spinal health management.