Drug-loaded artificial rectum for transplantation and preparation method thereof

Abstract

The invention relates to a drug-loaded artificial rectum for transplantation and a preparation method thereof. The artificial rectum comprises an intestinal tract stent inner layer and an intestinal tract stent outer layer, wherein the intestinal tract stent inner layer is of a latticed cylindrical structure prepared by mixing biological materials and loaded drugs; the intestinal tract stent outerlayer is of a compact cylindrical structure prepared from a biological material, and the intestinal tract stent outer layer is integrally formed on the periphery of the intestinal tract stent inner layer; and therefore, the intestinal tract stent inner layer and the intestinal tract stent outer layer jointly form an intestinal tract for flowing of intestinal volume, and the intestinal tract stent inner layer can release loaded drugs into the intestinal tract. The artificial rectum completely simulates the real tissue of a human body, can be suitable for different disease stages and physiological conditions of a patient, can simulate the normal physiological activity of the human body to achieve long-term implantation and normal use, and guarantees the sealing performance; and moreover, the artificial rectum can slowly release anti-inflammatory drugs and drugs for regulating intestinal flora into the intestinal tract, and can replace the original structure and achieve the effects of resisting inflammation and regulating intestinal flora at the same time.

Description

technical field [0001] The invention relates to an artificial prosthesis, in particular to a drug-loaded artificial rectum for transplantation with anti-inflammatory effect and improved activity of intestinal flora and a preparation method thereof. Background technique [0002] Early middle and low rectal cancer is one of the most common malignant tumors of the digestive tract, accounting for about 75% of rectal cancer cases, and the lesion is located 3 to 9 cm away from the anal verge. At present, although local excision and anus-preserving surgery have received more and more attention, the lesion goes deep into the pelvis, the anatomical relationship is complicated, the operation is not easy to complete, and the recurrence rate after operation is high. Especially for tumors within 6cm from the anal verge, it is generally considered that radical resection must be performed to remove the entire rectum. [0003] In order to make up for the absence of the rectum, colon draggi...

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Problems solved by technology

[0004] However, the existing artificial rectum does not consider the factors of the intestinal flora and inflammatory response. The direct use of the shaped structure does not have the function of drug release, which is prone to infection and inflammation and may have a destructive effect on the original intestinal flora.

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