Application of compound in preparation of medicine for treating liver fibers
A technology for preparing drugs and compounds, which is applied in the field of medicine and can solve problems such as no effective treatment measures and pending research
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[0066] 1. Experimental method
[0067] The 8-week-old male C57BL / 6 was purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. through the Experimental Animal Center of Tsinghua University. All mice were housed in a specific pathogen-free barrier at the Experimental Animal Center of Tsinghua University, with free access to water and food. All animal experimental techniques were approved by the Biomedical Analysis Center of Tsinghua University Animal Ethics Committee.
[0068] First, animal models of mouse liver fibrosis with different degrees of severity were constructed, which were called early mouse liver fibrosis animal models ( figure 1 ) and advanced mouse liver fibrosis animal model ( figure 2 ), mice were injected intraperitoneally with 5mL / kg 10% CCL4 (CCL4:olive oil=1:9, v / v) to induce chronic liver injury, twice a week for 4 weeks (early stage) or 10 weeks (late stage). After induction of chronic liver injury, the mice were divided into earl...
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