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Application of holothurian cerebroside and derivatives thereof in products for improving blood-brain barrier injury

A technology for blood-brain barrier damage and cerebroside, which is applied in the preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., can solve problems such as affecting the structure and function of membrane proteins, and achieve good results in reducing blood-brain barrier damage. , the effect of broad market prospects

Active Publication Date: 2020-08-18
OCEAN UNIV OF CHINA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that sea cucumber cerebroside can significantly improve the structure and function of cell membranes, thereby affecting the structure and function of membrane proteins, but its application in improving blood-brain barrier damage has not been reported

Method used

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  • Application of holothurian cerebroside and derivatives thereof in products for improving blood-brain barrier injury
  • Application of holothurian cerebroside and derivatives thereof in products for improving blood-brain barrier injury
  • Application of holothurian cerebroside and derivatives thereof in products for improving blood-brain barrier injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Blood-brain barrier injury induced by ischemia-reperfusion

[0028] 1.1 Experimental method

[0029] 1.1.1 Experimental design

[0030] The experimental animals were male Balb / c mice, weighing 22-23 g, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. The mice were divided into 12 groups: sham operation group (N), model group (M), fungal cerebroside group (FC), three series of sea cucumber cerebrosides (SCC1, SCC2 and SCC3), sea cucumber brain Glycoside derivative ceramide group (Cer1, Cer2 and Cer3) and sea cucumber cerebroside derivative long-chain base group (LCB1, LCB2 and LCB3). Mice in the sham operation group and the model group were fed with modified AIN-93G rodent diet. The mice in the fungal cerebroside group were fed with the feed supplemented with 0.5% fungal cerebroside, and the other groups were fed with the same molar amount of the test substance as in the FC group. Three weeks later, ischemia-reperfusion was per...

Embodiment 2

[0034] Example 2: Blood-brain barrier damage induced by lead acetate

[0035] 2.1 Experimental method

[0036] 2.1.1 Experimental design

[0037] The experimental animals were male Balb / c mice, weighing 22-23 g, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. The mice were divided into 12 groups: normal group (N), model group (M), fungal cerebroside group (FC), sea cucumber cerebroside three series groups (SCC1, SCC2 and SCC3), sea cucumber cerebroside Lipid derivative ceramide group (Cer1, Cer2 and Cer3) and sea cucumber cerebroside derivative long-chain base group (LCB1, LCB2 and LCB3). Except the normal group, all the mice were fed with 50 mg / kg lead acetate every day for 9 weeks. Meanwhile, mice were fed a modified AIN-93G rodent diet. After 6 weeks, the mice in the fungal cerebroside group were fed with the feed supplemented with 0.5% fungal cerebroside, and the other groups were fed with the same molar amount of the test substance as the...

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Abstract

The invention relates to a new application of holothurian cerebroside and a derivatives thereof, in particular to an application of holothurian cerebroside and derivatives thereof in products for improving blood-brain barrier injury. Experiments prove that the holothurian cerebroside remarkably reduces blood-brain barrier injury caused by ischemia reperfusion and blood-brain barrier injury causedby lead acetate, the effect of the holothurian cerebroside and derivatives thereof in improvement of the blood-brain barrier is verified for the first time, and a new way is provided for treatment ofthe blood-brain barrier.

Description

Technical field: [0001] The invention relates to the new application of sea cucumber cerebroside and its derivatives, in particular to the application of sea cucumber cerebroside and its derivatives in improving blood-brain barrier damage products. Background technique: [0002] Blood-brain barrier damage is the main pathological feature of stroke, the culprit of vasogenic cerebral edema and cerebral hemorrhage, and is closely related to neurodegenerative diseases such as Alzheimer's disease. At present, there is no drug that can effectively protect the blood-brain barrier in clinical practice. Studies have shown that sea cucumber cerebroside can significantly improve the structure and function of cell membranes, thereby affecting the structure and function of membrane proteins, but its application in improving blood-brain barrier damage has not been reported. [0003] Cerebroside is a kind of neutral glycosphingolipid, also known as acylceramide hexoside, its structure is ...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61K31/164A61K31/133C07H15/10C07H15/04C07H1/08C07C233/18C07C233/20C07C235/08C07C235/28C07C231/24C07C215/10C07C215/24C07C213/10A61P25/28A61P9/00A61P9/10A23L33/10
CPCA23V2002/00A61K31/133A61K31/164A61K31/7032A23L33/10A61P9/00A61P9/10A61P25/28C07B2200/07C07C213/10C07C215/10C07C215/24C07C231/24C07C233/18C07C233/20C07C235/08C07C235/28C07H1/08C07H15/04C07H15/10A61K2300/00A23V2200/322A23V2200/326A23V2250/2042
Inventor 王玉明王成成张恬恬薛长湖薛勇李兆杰徐杰王静凤常耀光唐庆娟毛相朝姜晓明丛培旭
Owner OCEAN UNIV OF CHINA
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