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A kind of inorganic rapid hemostasis material and preparation method thereof

A hemostatic material and rapid technology, which can be used in pharmaceutical formulations, medical science, surgery, etc., can solve the problems of limited adhesion of hemostatic materials, difficulty in subsequent processing, and reduced hemostatic ability, etc. The effect of wound healing and strong suction ability

Active Publication Date: 2022-06-21
湘潭海美斯泰科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned hemostatic materials have the following problems: the amount of adhesion of the hemostatic material is limited, and the particles adhering to the substrate are easy to fall off, which will lead to the reduction of its hemostatic ability and the difficulty of subsequent processing.
The preparation method and application of this sepiolite composite material have not been reported

Method used

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  • A kind of inorganic rapid hemostasis material and preparation method thereof
  • A kind of inorganic rapid hemostasis material and preparation method thereof
  • A kind of inorganic rapid hemostasis material and preparation method thereof

Examples

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Effect test

Embodiment approach 1

[0028] The purpose of the first embodiment of the present invention is to provide a kind of inorganic rapid hemostatic material, and the preparation steps are as follows:

[0029] (a) Mix and grind 20g of sepiolite raw material with 2ml of deionized water, add 300ml of deionized water and stir to form suspension A after grinding, centrifuge suspension A, scrape the upper layer sediment and disperse in In deionized water, suspension B was formed;

[0030] (b) Add hydrochloric acid solution to suspension B to acidify to PH=3, let it stand for sedimentation, take the sediment and continue to disperse it in deionized water, and repeat acidification 3 times. Get the precipitate and disperse it in deionized water to form a suspension C, add sodium hydroxide solution to the suspension C to pH=9, let stand for settling, take the precipitate and continue to disperse it in deionized water, repeat the alkali treatment for 3 Second-rate. Disperse the precipitate in 200ml of saturated so...

Embodiment approach 2

[0036] The purpose of the second embodiment of the present invention is to provide a kind of inorganic rapid hemostatic material, and the preparation steps are as follows:

[0037](a) Mix and grind 20g of sepiolite raw material with 2ml of deionized water, add 300ml of deionized water and stir to form suspension A after grinding, centrifuge suspension A, scrape the upper layer sediment and disperse in In deionized water, suspension B was formed;

[0038] (b) Add hydrochloric acid solution to suspension B to acidify to PH=3, let it stand for sedimentation, take the sediment and continue to disperse it in deionized water, and repeat acidification 3 times. Get the precipitate and disperse it in deionized water to form a suspension C, add sodium hydroxide solution to the suspension C to pH=9, let stand for settling, take the precipitate and continue to disperse it in deionized water, repeat the alkali treatment for 3 Second-rate. Disperse the precipitate in 200ml of saturated so...

Embodiment approach 3

[0044] The purpose of the second embodiment of the present invention is to provide a kind of inorganic rapid hemostatic material, and the preparation steps are as follows:

[0045] (a) Mix and grind 20g of sepiolite raw material with 2ml of deionized water, add 300ml of deionized water and stir to form suspension A after grinding, centrifuge suspension A, scrape the upper layer sediment and disperse in In deionized water, suspension B was formed;

[0046] (b) Add hydrochloric acid solution to suspension B to acidify to PH=3, let it stand for sedimentation, take the sediment and continue to disperse it in deionized water, and repeat acidification 3 times. Get the precipitate and disperse it in deionized water to form a suspension C, add sodium hydroxide solution to the suspension C to pH=9, let stand for settling, take the precipitate and continue to disperse it in deionized water, repeat the alkali treatment for 3 Second-rate. Disperse the precipitate in 200ml of saturated s...

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Abstract

The invention discloses an inorganic rapid hemostatic material and a preparation method thereof. The inorganic rapid hemostatic material is sepiolite fiber. The present invention has the following beneficial effects: 1. It has the characteristics of quick hemostasis of wound, promotion of wound healing, absorption of body fluid and maintenance of wound humidity; 2. Very strong liquid absorption capacity, the highest water absorption capacity can reach 100%-120% of its own mass; 3. The hemostatic effect is good, which increases the local concentration of platelets and promotes the network of fibrin, so as to achieve the purpose of rapid hemostasis; 4. It can adjust the humidity of the wound surface. release, maintain the humidity of the wound surface, is conducive to cell proliferation and epithelialization, thereby promoting wound healing, and attaching silver nanoparticles to sepiolite fibers has bactericidal and anti-infective effects; 5. High porosity allows oxygen to pass through and isolates bacteria , helps tissue growth; 6. Does not contain organic solvents, binders, and other toxic and harmful substances, and will not pollute the environment after use; 7. Good processing performance and hydrophilicity make this hemostatic material easy to combine with chitosan , alginate, etc. are used as wound materials.

Description

Technical field: [0001] The invention relates to an inorganic rapid hemostatic material and a preparation method thereof. Background technique: [0002] Rapid bleeding is often encountered in natural disasters, war conflicts, surgical operations and accidental accidents. If bleeding cannot be controlled in time, it is easy to endanger the lives of the injured. Currently reported zeolite, oxidized cellulose, chitosan, alginate, collagen and starch polysaccharides are used for rapid hemostasis. These materials have their own advantages and disadvantages, such as zeolite easily lead to tissue necrosis, gelatin and cellulose cause local adhesion. Currently, mature products on the market include biocompatible and degradable cellulose dressings, but their hemostatic effects are weak and cannot inhibit bacterial proliferation inside the dressings. American Medafor company uses absorbable hemostatic microspheres for hemostasis. The Aristide hemostatic powder developed by Medafor i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/02A61L24/00A61L26/00
CPCA61L24/02A61L24/0015A61L26/0004A61L26/0066A61L2400/04A61L2400/12A61L2300/104A61L2300/404A61L2300/412A61L2300/10
Inventor 丁燕怀蒋运鸿彭张哲杨勇文欧阳东红姜文武梅昱帆
Owner 湘潭海美斯泰科技有限公司
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