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Tumor cell culture information analysis method

A technology for tumor cell and information analysis, which is applied in the fields of analysis materials, biochemical equipment and methods, and material separation, and can solve problems such as the difficulty in studying differences in phospholipid composition

Inactive Publication Date: 2020-09-15
南京融康博生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitation of detection technology, the analysis of membrane lipids is mostly limited to the analysis and identification of the total lipids. Due to the overlap of different fatty acid chromatographic peaks, it is difficult to study the differences in phospholipid composition of different tumor cells.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] S1. Tumor cell culture, provide tumor cells as starting cells, the tumor cells come from the same tumor tissue of the same subject, put the tumor cells into the culture medium for culture, and divide the culture samples into Class I, Class II and Class III, As a follow-up information comparison;

[0026] S2. Pharmacological culture. First, vascular endothelial cells are seeded on the osmotic support membrane of the culture container to form a vascular endothelial cell layer; the initial cells are placed on the osmotic support membrane vascular endothelial cell layer and form a semi-solid gel-like mixture. For the first, second and third types of culture, add anti-tumor drugs to the samples, collect the cell fluid in the culture container after culture, and count the cells. According to the number of cells in the culture container, the strength of the cell migration ability can be detected. weak;

[0027] S3. Cell membrane phospholipid extraction. After the tumor cell c...

Embodiment 2

[0032] A method for analyzing tumor cell culture information, comprising the steps of:

[0033] Step 1. Tumor cell culture, provide tumor cells as starting cells, the tumor cells come from the same tumor tissue of the same object, put the tumor cells into the medium for culture, and divide the culture samples into class I, class II and class III , as a follow-up information comparison, Class I, Class II and Class III correspond to early cells, mid-stage cells and late cells of tumor cells respectively, and the medium consists of 10% acellular ascites, 3% fetal bovine serum, 1% double Antibody, the rest is composed of DMEM medium;

[0034] Step 2, pharmacological culture, first inoculate vascular endothelial cells on the osmotic support membrane of the culture container to form a vascular endothelial cell layer; the osmotic support membrane is made of organic materials, and the initial cells are placed above the vascular endothelial cell layer of the osmotic support membrane an...

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PUM

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Abstract

The invention discloses a tumor cell culture information analysis method. The method comprises the following steps: tumor cell culture, pharmacological culture, cell membrane phospholipid extraction,cell membrane phospholipid methyl esterification, gas phase technology analysis and information comparison. The vascular endothelial cells are inoculated on an osmotic support membrane of a culture container to form a vascular endothelial cell layer; initial cells are placed on the vascular endothelial cell layer of the osmotic support membrane to form a semi-solid gel mixture; in the first-class,second-class and third-class culture process, an anti-tumor drug is added into a sample, cell sap in the culture container is collected after culture, cell counting is conducted on the cell sap, andthe cell migration capacity can be detected according to the number of cells in the culture container.

Description

technical field [0001] The invention belongs to the field of cell culture, and more specifically relates to a method for analyzing tumor cell culture information. Background technique [0002] Malignant tumors have become one of the major diseases that seriously threaten human life and health. They have the characteristics of high morbidity and high mortality. The occurrence of tumors increasingly affects economic development and people's health. Therefore, it is imminent to take effective methods of preventing and treating tumors to curb the development of malignant tumors. [0003] Many diseases, including tumors, are accompanied by changes in membrane phospholipid metabolism. Changes in cell membrane phospholipids will affect the physical and chemical properties of cell membranes, and then affect the biological functions of various membrane proteins. Studying the changes of cell membrane phospholipids not only helps to elucidate the pathogenesis of these diseases and tum...

Claims

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Application Information

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IPC IPC(8): G01N30/02C12Q1/02
CPCG01N30/02G01N33/5011
Inventor 刘译远劉瑞宸拉斯洛谢克利
Owner 南京融康博生物科技有限公司