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Thromboelastic signal extraction method, storage medium and computer equipment

A technique for thromboelasticity and signal extraction, applied in instruments, measuring devices, scientific instruments, etc., can solve the problems of narrow band-pass filter bandwidth, high Q value, easy to be interfered by noise, etc., and achieves improved computational complexity and easy processing , good processing effect

Active Publication Date: 2022-06-17
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To achieve a sufficient signal-to-noise ratio, the bandwidth of the bandpass filter must be very narrow, and the Q value must be very high, which is often difficult to achieve in practice
The method of calculating the signal amplitude by simply finding the extreme value in the time domain is more susceptible to noise interference, and it is generally difficult to achieve better results

Method used

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  • Thromboelastic signal extraction method, storage medium and computer equipment
  • Thromboelastic signal extraction method, storage medium and computer equipment
  • Thromboelastic signal extraction method, storage medium and computer equipment

Examples

Experimental program
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Effect test

Embodiment 1

[0059] In this embodiment, in the thromboelastometry system, the oscillation period of the blood sample cup is 10s, and the oscillation angular displacement signal of the probe is sampled. The sampling time is the oscillation period of 10s, and the sampling rate is 100Hz. image 3 The sequence shown, the specific steps are:

[0060] 1. In each sampling time interval of 10s, the number of sampling data points of the angular displacement signal is 1000, and the sequence is obtained:

[0061] data_array[n], n=0,1,...999;

[0062] Using 1000 data in each sampling time, a value of the thromboelastic signal representing the oscillation period can be obtained.

[0063] 2. Generate a sequence of radians:

[0064] angle_array[n]=2π*n / 1000,n=1,2,...,999;

[0065] 3. Generate a sine sequence:

[0066] sin_array[n]=sin(angle_array[n]), n=0,1,...,999;

[0067] 4. Get the cosine sequence:

[0068] The cosine sequence is not generated separately, and is obtained by using the sine seque...

Embodiment 2

[0097] Example 2 Adding single frequency noise and white noise

[0098] The single-frequency noise and white noise of non-blood sample cup oscillation period are superimposed on the original sampling sequence, Figure 7 To add noise to the angular displacement signal graph, Figure 8 , Figure 9 is the local detail map of the signal ( Figure 8 and 9 The abscissa in represents the number of sampling points in an interval). Figure 10 for Figure 7 It can be seen that the increased single-frequency noise and white noise have no obvious effect on the processing results.

Embodiment 3

[0099] Example 3 Adding short-time impulses to simulate the vibration of the detection platform

[0100] A short-time impulse signal is added to the original sampling sequence to simulate the situation when the platform vibration is detected. Figure 11 For the angular displacement signal at this time, Figure 12 , Figure 13 is the local detail map ( Figure 12 and 13 The abscissa in represents the number of sampling points in an interval). Figure 14 for Figure 11 Thromboelasticity signal graph after processing the mid-angle displacement signal, it can be seen that after the short-term impulse of simulated vibration is added, the processing result has no obvious effect.

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Abstract

The invention discloses a thrombus elastic signal extraction method, storage medium and computer equipment. The method comprises the following steps: performing data sampling on angular displacement signals; generating an arithmetic arc sequence; generating sine and cosine sequences; combining the sampling sequence with sine, Do point multiplication of the cosine sequence respectively, and calculate the average value of the elements; obtain the thromboelastic signal in a single cycle; repeat the steps to obtain the thromboelastic signal in multiple cycles, and produce positive edge signal sequence and negative edge signal sequence, thus forming a complete Thromboelastic signal. The method of the present invention can not only process ideal sampling signals well, but also suppress various noise components contained in the angular displacement signal of the probe during the actual working process of the equipment, such as the vibration signal of the detection platform and the noise of the measurement system. , the damped oscillation when the probe leaves the initial position, etc., so as to obtain more accurate thromboelastic signals.

Description

technical field [0001] The invention relates to the technical field of thromboelasticity measurement, in particular to a method for extracting a thromboelasticity signal, a storage medium and a computer device. Background technique [0002] During the coagulation process, fibrin, platelets and blood cells form a three-dimensional networked structure, and the blood viscoelasticity changes accordingly and is monitored by the thromboelastometry system. Through data processing, a thromboelastogram and a series of detection indicators are generated to qualitatively or quantitatively analyze the coagulation process. . [0003] The principle of thromboelastometry is as follows figure 1 : A special blood sample cup filled with blood, reciprocating oscillation at a fixed angle and a fixed frequency around its central axis of symmetry on the horizontal plane. A probe suspended by a wire is soaked in the blood sample. In the process of blood coagulation, the blood clot couples the b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/49
CPCG01N33/4905
Inventor 钱俊孙海旋李俊坡梁伟国王弼陡杨维闫雪松王钟周
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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